HOME >> MEDICINE >> NEWS
Tumor-targeted immune cells cure prostate cancer in mice without causing systemic immune suppression

In a major breakthrough in cancer gene therapy, a Northwestern University researcher has endowed immune cells with the ability to specifically target metastatic prostate cancer in mice without causing the toxic immune suppression that has been associated with earlier forms of cancer gene therapy.

Chung Lee, John T. Grayhack, M.D., Professor of Urology at Northwestern University Feinberg School of Medicine, and his laboratory group described the adoptive transfer gene therapy technique in the March issue of Cancer Research.

Lee is also a researcher at The Robert H. Lurie Comprehensive Cancer Center of Northwestern University. The researchers first rendered immune cells known as CD8+ T cells insensitive to transforming growth factor beta (TGF-beta), a powerful, naturally occurring substance in the body that enables cancer cells to evade surveillance by the body's immune system. The immunosuppressive effect of TGF-beta in cancer progression is well established.

After inserting a mutated form of the TGF-beta receptor into CD8+ T cells, Lee and associates transplanted the tumor-specific immune cells into mice that had been given a particularly aggressive form of prostate cancer, called TRAMP-C2.

TRAMP-C2 prostate cancer cells produce large amounts of TGF-beta, and possess such potent immunosuppressive power that regular CD8+ T cells are unable to infiltrate tumor tissues, Lee explained.

The mice received a single injection of tumor-reactive TGF-beta-insensitive CD8+ T cells, tumor-specific TGF-beta-sensitive CD8+ T cells or untreated CD8+ T cells at three (early cancer), seven or 21 days (advanced cancer) after they had been injected with the prostate cancer cells.

Lee and co-researchers found that the tumor-reactive TGF-beta-insensitive CD8+ T cells infiltrated prostate cancer tumors and effectively destroyed the TRAMP-C2 cells.

Moreover, results showed that the CD8+ T cells showed five-fold more tumor-killing activity than
'"/>

Contact: Elizabeth Crown
e-crown@northwestern.edu
312-503-8928
Northwestern University
10-Mar-2005


Page: 1 2

Related medicine news :

1. Chemists identify immune system mechanism for methamphetamine binges
2. Smart immune cells kill more cancer
3. New network of gastrointestinal immune cells discovered
4. Old T cells cripple immune function in the elderly
5. Novel p53 gene-based therapy boosts immune system and reduces tumor size
6. VGTI researchers help uncover why aging reduces immune system function
7. Brains immune system triggered in autism
8. Marine sponge leads researchers to immune system regulator
9. Mayo Clinic discovers one mechanism for why men and women differ in immune response
10. Longterm immune memory cells cells do not develop during chronic viral infections
11. Lab study defines and blocks mechanism that lets brain tumors sidetrack immune response

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/15/2019)... ... ... Nashville Fertility Center (NFC) is proud to announce that Kristin Van Heertum ... to treating general infertility, Dr. Van Heertum offers expertise in fertility surgery and treatment ... Van Heertum joining the practice and believes she is the perfect fit. According to ...
(Date:10/11/2019)... , ... October 11, 2019 , ... A Topping Out ... new headquarters facility by general contractors Adolfson & Peterson Construction. The event celebrated reaching ... at 8190 Midtown Road in Dallas. The first of its kind in Texas, STA’s ...
(Date:10/10/2019)... (PRWEB) , ... October 10, 2019 , ... Caring.com, a ... Report on the Best and Worst Places for Seniors to Live. All 50 states ... engagement, transportation, quality of life and workforce development. , According to the ...
(Date:10/8/2019)... ... 2019 , ... What unique insights can three former Surgeons General of the ... the nation? That question will be answered at ICAA 2019: Shaping the Future of ... event will take place October 10-12, 2019, at the Gaylord Palms Resort and Convention ...
(Date:10/8/2019)... CA (PRWEB) , ... October 08, 2019 , ... Dr. ... gum disease in San Jose, CA experience relief from this common and treatable condition. ... in order to save adults from living with uncomfortable symptoms, including tender and bleeding ...
Breaking Medicine News(10 mins):
(Date:10/8/2019)... ... October 08, 2019 , ... ... farmers a wider range of novel, microbial-based crop protection products. , Under the ... natural product starting points. In a first for the agriculture industry, Corteva will ...
(Date:10/8/2019)... ... October 08, 2019 , ... ... today announced that FocalPoint Holdings, a privately-held investment and management firm specializing ... more than 8,000 ophthalmology and optometry providers Luma Health’s patient relationship technology ...
(Date:10/8/2019)... ... October 08, 2019 , ... AdventHealth Wesley ... and provide safer, convenient options for patients who require treatment. The hospital is ... enhanced mammography is used to detect tumors in dense breasts that may not ...
Breaking Medicine Technology:
Cached News: