Twice daily imatinib could improve outcome for people with specific form of gastro-intestinal cancer

This release is also available in German.

Results of a randomised trial in this week's issue of THE LANCET suggest that a single daily 400 mg dose of imatinib--known to be a first-choice treatment for gastro-intestinal stromal tumours (GIST)--is sufficient to induce a therapeutic response; a doubling of a daily dose can slightly improve progression-free survival for patients.

Imatinib is approved worldwide for use in GIST, tumours which do not respond to conventional chemotherapy, which have a prevalence of around 20 per 100,000 population. Jaap Verweij (Erasmus University Medical Center, Netherlands) and colleagues from the European Organisation for Research and Treatment of Cancer (EORTC), the Italian Sarcoma Group (IRG), and the australasian Gastrointestinal Trials Group (AGITG) studied 946 patients with metastatic GIST who were randomly allocated either imatinib 400 mg once or twice a day.

50% of patients receiving two doses of imatinib a day, compared with 56% of patients given a single dose, were alive and free of disease progression at around 2 years follow-up. There was no difference in the proportion of patients (99%) who reported treatment side-effects; the optimum time for therapeutic effect after the start of treatment did not differ between the two groups (around 4 months).

Dr Verweij comments: "If the aim of treatment is response induction, a daily dose of 400 mg given for 46 months seems to be sufficient. However, in patients with widespread metastatic disease, the prolonged progression-free survival achieved with 400 mg twice daily might lead one to favour this regimen. Whether a similar outcome could be achieved with fewer side-effects by making use of the reduction in drug clearance over time--eg, with a starting dose of 400 mg daily followed by stepwise dose escalation to 400 mg twice a day--is still a matter for further clini

Contact: Joe Santangelo

Page: 1 2

Related medicine news :

1. Study: Among Heart Failure Patients, Women Survive Twice As Long As Men
2. Bullying among sixth graders a daily occurrence, UCLA study finds
3. Current daily smoking may be associated with increased risk for suicidal thoughts and attempts
4. African children with HIV would benefit from daily doses of cheap antibiotic
5. Weekend use matches daily drops for lazy eye
6. New ways identified to treat lazy eye in children: Beyond eye patches and daily drops
7. Weekly cycles of once-daily anti-HIV drugs could reduce cost of HIV treatment
8. Study finds once-daily Valcyte prevents serious viral infection after kidney transplant
9. Max daily OTC dose of acetaminophen shows efficacy comparable to Rx doses of naproxen for OA pain
10. New study finds even a small amount of psoriasis can negatively impact daily life
11. OHSU study shows four daily servings of fruits & vegetables reduce breast cancer risk by half

Post Your Comments:

(Date:11/24/2015)... (PRWEB) , ... November 24, 2015 , ... DMG Productions ... Ed Begley Jr., airing first quarter 2016 via Discovery Channel. Dates and show times ... the Province, and is in the business of producing and supplying medical marijuana pursuant ...
(Date:11/24/2015)... ... November 24, 2015 , ... ... will waive paid entry and parking fees at several of their most popular ... in Great Barrington in support of REI’s Black Friday #OptOutside Campaign. The Trustees ...
(Date:11/24/2015)... ... November 24, 2015 , ... ... their knowledge and experiences at a live taping of the next CURE ... the Cure of Gastrointestinal Cancers 2015 Symposium at Georgetown University Hotel & Conference ...
(Date:11/24/2015)... ... November 24, 2015 , ... With Thanksgiving right around ... sharing safety tips to help protect your family and vehicle. , According to the ... 2013 Thanksgiving holiday weekend. Amica is sharing the following safety tips from the NHTSA: ...
(Date:11/24/2015)... ... November 24, 2015 , ... Chiropractic student ... City (CU-KC), in Overland Park, Kansas. Benson, a fifth-trimester student in the ... S. Cleveland III on October 16. , “Katie is very excited and greatly ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)...  NuShield, Inc., an industry leader in LCD screen protection and glare-elimination technology, is providing a ... of their patient monitoring or electronic documentation system. ... ... ... A study in 2013 by the National ...
(Date:11/24/2015)... 24, 2015 Abaxis, Inc. (NasdaqGS: ABAX ... consumables for the medical, research, and veterinary markets worldwide, ... Officer, will present at the 27 th Annual ... at 11:30 a.m. ET. The conference will be held ... New York City . Abaxis, Inc. ...
(Date:11/24/2015)... Nov. 24, 2015  Wellness Center USA , Inc. ... its flagship product, Psoria-Light® (PL 1000), to targeted dermatology markets in ... Minnesota , and North Carolina . This follows ... , Chicago , and New York ... Revenue for the earlier shipments reported on October 1, 2015 will ...
Breaking Medicine Technology:
Cached News: