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Type 2 diabetes and pre-diabetes are undetected in over one quarter of obese population

Over one quarter of obese people may have previously undetected or untreated type 2 diabetes or pre-diabetes (impaired glucose tolerance, IGT) according to data presented today at the European Association for the Study of Diabetes (EASD) meeting in Budapest, Hungary 1. This translates to around 100 million people worldwide who may be at risk of the serious health problems associated with untreated diabetes.

The data presented at EASD were a new finding of the XENDOS study (XENical in the prevention of Diabetes in Obese Subjects)2. The results of the 4 year landmark XENDOS study involving 3304 patients demonstrated that the weight loss medication Xenical can prevent or delay the development of type 2 diabetes. Furthermore, the XENDOS study data showed significant and sustained weight loss with Xenical over the long term.

Commenting on the study, XENDOS co-principal investigator Dr Jarl Torgerson said: "This study shows that the scale of the type 2 diabetes epidemic is alarming. Studies like the Diabetes Prevention Program (DPP) have shown that lifestyle change is the basis of preventing diabetes, but by adding Xenical people could go even further in preventing the disease, and that's a real breakthrough."

XENDOS study results showed that:

  • 28.3% of obese people had previously undetected or untreated diabetes or pre-diabetes (IGT) The risk of having type 2 diabetes increased with increasing Body Mass Index (BMI), increasing age, and male gender
  • The risk of developing type 2 diabetes was 37% lower in people treated with Xenical plus lifestyle intervention compared with lifestyle intervention alone
  • Weight loss, both in the short and the long term, was significantly greater with Xenical plus lifestyle intervention compared with lifestyle intervention alone (-11.4 vs -7.5 kg at one year and -6.9 vs -4.1kg at four years)
  • Xenical-treated patients had significant, sustained, long-term
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Contact: Liz Gofton
liz.gofton@shirehealthinternational.com
44-207-471-1518
Shire Health International
3-Sep-2002


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