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UB begins groundbreaking study on 'net effect' on patients of HIV treatments, other drugs

s as to how AIDS drugs are absorbed, distributed and metabolized," he said, "but right now are all prescribed as though 'one size fits all,' according to fixed-dose regimens."

In addition to looking at blood concentrations of drugs and interactions, Morse said the study will examine the levels of multiple drugs that bind to plasma proteins in each patient. "The amount of plasma protein-binding can vary from patient to patient and that can have important clinical implications," said Morse. "For example, the more highly bound to protein the drug is in plasma, then the less there is to get to the tissue sites where HIV can replicate." The study, he added, also is aimed at uncovering some of the long-term toxicities from these drugs, which are becoming an increasing concern because people are living longer with HIV infection.


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Contact: Ellen Goldbaum
goldbaum@buffalo.edu
716-645-5000 x1415
University at Buffalo
3-Sep-2003


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