HOME >> MEDICINE >> NEWS
UCI resarchers create first living model to exhibit

Irvine, Calif. -- A newly engineered, genetically altered mouse will allow researchers for the first time to study the two signature lesions of Alzheimer's disease in a single organism -- a model that closely matches how the disease develops in the human brain. Created by UC Irvine neurobiologists Frank LaFerla and Salvatore Oddo, the mouse is expected to provide a better "living laboratory" for understanding how these lesions grow, aiding efforts to find an effective treatment for both the sporadic and inherited forms of the disease.

"For the first time, plaque and tangle lesion formations can be studied together, letting us understand the relationship between the two lesions and dissect the processes by which they may be connected," said LaFerla, a professor of neurobiology and behavior, and senior author of the study, which appears in the July 31 issue of Neuron.

Plaque lesions grow on the outside of healthy cells, cutting off their ability to communicate with other cells, while tangle lesions grow inside of neural cells and clog signaling pathways. Plaque lesions are factors in the early-onset inherited and sporadic forms of the disease, and tangle lesions are found primarily in the sporadic form.

According to LaFerla, the mouse will be valuable in the search for drugs that can target both lesions. "This may eventually lead to a single class of drugs for treating both the inherited and sporadic forms of the disease," he said. "We now have the ability to study a wider spectrum of Alzheimer's disease than previously possible."

LaFerla and Oddo created the mouse by genetically altering it to host three mutant human genes that foster lesion growth: beta-amyloid precursor protein (APP), presenilin-1 and tau. APP is the source of the beta-amyloid protein that forms into brain plaques, while presenilin-1 is needed for this protein to form. Tau is the critical component of tangles.

Using the triple-transgenic mouse, the UCI researchers hav
'"/>

Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
30-Jul-2003


Page: 1 2 3

Related medicine news :

1. Massive weight loss patients create mass appeal for body contouring procedures
2. High-intensity ultrasound creates hollow nanospheres and nanocrystals
3. Mayo Clinic researchers create obedient virus; First step to use measles virus against cancer
4. Brown and NIH create joint neuroscience graduate program
5. Genetically targeted therapies create opportunities to do business in new ways
6. UGA researchers receive NIH contract to create a stem cell-based drug assay for SMA
7. Selective coatings create biological sensors from carbon nanotubes
8. Jefferson and Molecular Targeting Technologies, Inc. scientists create vaccine for wildlife rabies
9. Wipeout! Surfing creates wave of unique injuries
10. NCI scientists create model that predicts follicular lymphoma survival
11. All chronic sinusitis is not created equal, study finds

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/10/2020)... (PRWEB) , ... July 10, 2020 , ... ... overwhelming for people with spinal cord disease or injury and social distancing makes ... pandemic can induce symptoms of anxiety, depression, distress, and PTSD amongst our adult ...
(Date:7/10/2020)... ... July 09, 2020 , ... ... needs in the field of urology, today announced that Miguel Mercado, M.D., Texas ... Excellence. The designation recognizes that Dr. Mercado has achieved a high level of ...
(Date:7/10/2020)... Calif. (PRWEB) , ... July 10, 2020 , ... ... focused on addressing unmet needs in the field of urology, today announced that ... designated as a UroLift® Center of Excellence. The designation recognizes that Dr. Meyer ...
(Date:7/10/2020)... ... July 10, 2020 , ... 3Lions ... our Business Partner Vetting (BPV) Portal . Expresso® 3.0 contains a Portal ... No more manually mailing, tracking, and performing other administrative tasks that amount ...
(Date:7/7/2020)... ... 07, 2020 , ... Dr. Louis M. DeJoseph is proud to ... scalp health. It is now possible to receive Keravive treatments from HydraFacial at the ... Dr. DeJoseph is able to provide clients with the best services to help them ...
Breaking Medicine News(10 mins):
(Date:7/10/2020)... ... July 10, 2020 , ... COMPLIANCY GROUP in its continued ... Associates. Business associates create, receive, transmit, store, and maintain protected health information (PHI) ... to be HIPAA compliant, ensuring the confidentiality, integrity, and availability of PHI. ...
(Date:7/10/2020)... FRANCISCO, Calif. (PRWEB) , ... ... ... Pharmaceutical Review , the leading review of business and technology for the ... cover the development and manufacturing of the highest quality pharmaceutical products. ...
(Date:7/7/2020)... Ariz. (PRWEB) , ... July 07, 2020 , ... ... providing emergency medical assistance to Navajo Nation residents, the 33 nonprofits who received ... communities worldwide. In its fourth round of funding, the foundation awarded grants totaling ...
Breaking Medicine Technology:
Cached News: