HOME >> MEDICINE >> NEWS
UCSD and Japanese researchers identify new gene involved in development and function of central nervous system

A new gene directly involved in the migration of neurons to the developing brain, and then in the ongoing function of the mature central nervous system, has been identified and described by researchers from the UCSD School of Medicine and the Shirakawa Institute of Animal Genetics in Japan.

One of the mysteries of human development is how the vast number of cells that are produced following fertilization of an egg are deployed to create a human being. In the December 2000 issue of the journal Neuron, the research team describes a protein called NUDEL. NUDEL plays a critical role as part of a transport complex that includes LIS1, a protein identified in human patients with a severe neuronal migration defect. Together, these proteins regulate the function of motor-molecules called dyneins that transport cellular cargo such as organelles within the cell. This complex helps newly formed brain cells migrate to specific regions of the embryonic brain, ensuring proper development of the cerebral cortex, the center of intellectual and cognitive function.

The discovery of NUDEL helps us to fill in the details about how neurons in the developing brain become wired. It provides some new information about the way embryonic neuronal cells divide and travel to end up in the right place at the right time in order to make the proper connection in the adult brain, said Anthony Wynshaw-Boris, M.D., Ph.D., UCSD assistant professor of pediatrics and medicine and co-author of the Neuron paper.

As we increase our knowledge of neuron migration and the pathways by which the proper connections are made, we might discover new approaches to treating neurodegenerative diseases linked to breakdowns in this transport system, added Shinji Hirotsune, M.D., Ph.D., of the Shirakawa Institute of Animal Genetics. We might also be able to develop innovative ways to repair lesions using these pathways to deliver therapies directly to the diseased part of the brain.


'"/>

Contact: Sue Pondrom
spondrom@ucsd.edu
619-543-6163
University of California - San Diego
20-Dec-2000


Page: 1 2 3

Related medicine news :

1. Dec. 10-12 Japanese-American Frontiers of Science Meeting in Irvine, Calif.
2. Japanese chemist wins U.S. award for molecular discoveries
3. Americans Skip Dialysis; Swedes And Japanese Dont, Wake Forest Study Shows
4. Indiana University researchers closer to helping hearing-impaired using stem cells
5. Protein that helps skin cancer spread identified by Stanford researchers
6. US life expectancy about to decline, researchers say
7. Gene for age-related macular degeneration discovered by Yale researchers
8. Dartmouth researchers find where musical memories are stored in the brain
9. Columbia researchers receive $3 million to combat genetic killer of infants & toddlers
10. US cancer researchers launch first American-Israeli cancer conference
11. USC dental researchers develop first test for predicting cavities in children

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/30/2021)... , ... March 29, 2021 , ... ... the 21st Century , A Virtual Workshop Presented by WCG FDAnews and Cerulean ... 4:30 pm EDT, https://wcg.swoogo.com/modern-sop-and-quality-systems , Are one’s SOPs written for the ...
(Date:3/30/2021)... ... March 29, 2021 , ... According to data released ... reproductive age (13-44) in need of publicly funded contraception live in counties impacted by ... Colorado’s 64 counties have lost some of their Title X resources. , The ...
(Date:3/30/2021)... ... March 29, 2021 , ... Health Literacy Innovations (HLI), a ... confusion due to low health literacy today announces a new partnership with the ... work with ACAP’s member Safety Net Health Plans, those that provide comprehensive health ...
(Date:3/30/2021)... ... ... Dr. Colin Campbell is proud to announce the 1 year anniversary in their new state ... internal medicine and is a primary care specialist who has been practicing for 23 years. ... keep South Jersey healthy one patient at a time. , “Over the past year, Dr. ...
(Date:3/30/2021)... ... March 30, 2021 , ... The COVID-19 ... and survivors; their families; and their caregivers. Crossroads4Hope is addressing the needs of ... emotional support system, MyGo2Support, which meets needs of people impacted by cancer, no ...
Breaking Medicine News(10 mins):
(Date:3/30/2021)... ... March 29, 2021 , ... The University of Texas Health Science Center ... San Antonio Multispecialty and Research Hospital, a destination center for research and treatment of ... In a nod to the COVID-19 pandemic, the ceremony was held virtually. , William ...
(Date:3/30/2021)... ... March 29, 2021 , ... Iora Health ... primary care, has partnered with Devoted Health , one of the fastest-growing ... across Maricopa County and provides seniors with the highest-quality care and experience possible, ...
(Date:3/30/2021)... CITY (PRWEB) , ... March 29, 2021 , ... ... has joined the Vaccine Credential Initiative (VCI), a group bringing together leading health ... record of vaccination status, based on open, interoperable standards. By joining the VCI ...
Breaking Medicine Technology:
Cached News: