HOME >> MEDICINE >> NEWS
UCSD researcher wins grant to study colon cancer in African-Americans

The California Cancer Research Program (CRP) of the state Department of Health Services has awarded a physician-scientist at University of California, San Diego (UCSD) a $600,000 grant to conduct a 3-year study of colon cancer in African-Americans.

John Carethers, M.D., assistant professor of medicine at UCSD School of Medicine and member of the UCSD Cancer Center, received the highest score possible in the granting process. There were 92 grants funded out of 302 applications submitted.

With this grant, Carethers and colleagues will study tissue samples from African-American colon cancer patients to determine the incidence and impact of a particular chromosomal abnormality, called microsatellite instability (MSI). This abnormality is associated with colorectal cancer development, particularly the more virulent types. African-Americans seem to suffer from a more aggressive form of the disease compared to whites.

"When compared to statistics for whites, African-Americans have only a slightly higher incidence of colorectal cancer, but they have much higher death rates," said Carethers. "We believe MSI may play an important role."

Preliminary research in Carethers' laboratory has shown that cells with this abnormality do not respond to the widely used chemotherapeutic agent 5-fluoruracil (5-FU). The researchers will now further test this observation by studying the medical records of patients who received 5-FU treatment and whose tissue tested positive for microsatellite instability.

Also, the team will study the genes mutated by microsatellite instability to determine if they might be useful in predicting a given tumor's potential for metastasis.

"The new insights gained from this work may reveal the need for new screening strategies and new chemotherapeutic agents," said Carethers. "In addition, we hope to gain a clearer understanding of tumor formation that will benefit all patients."

Every year, approximately 149,000 people in
'"/>

Contact: Nancy Stringer
nstringer@ucsd.edu
619-543-6163
University of California - San Diego
4-Jun-2000


Page: 1 2

Related medicine news :

1. U of M researcher says Viagra may cause permanent vision loss in some men
2. Indiana University researchers closer to helping hearing-impaired using stem cells
3. Protein that helps skin cancer spread identified by Stanford researchers
4. US life expectancy about to decline, researchers say
5. Gene for age-related macular degeneration discovered by Yale researchers
6. Dartmouth researchers find where musical memories are stored in the brain
7. Columbia researchers receive $3 million to combat genetic killer of infants & toddlers
8. US cancer researchers launch first American-Israeli cancer conference
9. Mayo Clinic researcher calls for improved newborn screening
10. Hard choices: Pitt researcher presents findings on when to accept organ transplants
11. Brain-scanning technologies need standards, according to Stanford researcher

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: UCSD researcher wins grant study colon cancer African Americans

(Date:11/26/2014)... Raleigh, NC (PRWEB) November 26, 2014 ... types of materials science can cause mesothelioma that looks ... just posted a new article on the research. ... at the Fraunhofer Institute for Toxicology and Experimental Medicine ... nanotubes. While all of the rats eventually ...
(Date:11/26/2014)... MN (PRWEB) November 26, 2014 Loffler ... by The Week in Imaging, an online information and ... services. This is the sixth consecutive year Loffler has ... recent years. , The Elite Dealer Awards honor the ... community. This year’s Elite Dealer honorees were chosen for ...
(Date:11/26/2014)... 26, 2014 Senior Planning Services, providing ... a nonprofit organization providing the adult demographic education ... help seniors navigate the rough seas of applying for ... seniors on the topic of Medicaid eligibility and proper ... process of applying for this coverage. , Senior ...
(Date:11/26/2014)... Call 866-997-4948 (Us-Canada Toll Free) Tel: ... details on sales(at)researchmoz(dot)us , Researchmoz.us announces a new ... 2014" with deep study of the report on the ... blood sugar. The global glucose monitoring market has a ... number of diabetics in the world. Their numbers have ...
(Date:11/26/2014)... Rouge, Louisiana (PRWEB) November 26, 2014 ... neck pain relief and specialists in minimally invasive ... K. Samer Shamieh into the rapidly growing provider ... specialists. The addition coincides with the network’s ... reliable medical treatment for Louisiana residents who are ...
Breaking Medicine News(10 mins):Health News:Multi-walled Nanotubes Linked to Mesothelioma in New Study, According to Surviving Mesothelioma 2Health News:Loffler Companies Recognized as an Elite Dealer for Sixth Consecutive Year 2Health News:Senior Planning Services Teams Up with SeniorNet To Educate Seniors On Medicaid Planning 2Health News:Latest Report on Diabetes Market 2014 - Global Market Size, Share, Trends and Forecast by Researchmoz.us 2Health News:Latest Report on Diabetes Market 2014 - Global Market Size, Share, Trends and Forecast by Researchmoz.us 3Health News:Louisiana Back Institute Welcomes Dr. K. Samer Shamieh into Medical Provider Network 2
(Date:11/26/2014)... China, Nov. 26, 2014 China Nepstar Chain ... "Company"), a leading retail drugstore chain in China based ... its unaudited financial results for the third quarter ended September ... 30, 2014: , Same store sales increased by ... , Revenue increased by 8.1% to RMB738.3 million (US$120.3 million) ...
(Date:11/24/2014)... 24, 2014 Juno Therapeutics today announced ... to the company,s JCAR015 chimeric antigen receptor product ... relapsed or refractory B-cell acute lymphoblastic leukemia and ... Kettering Cancer Center, where Phase 1 clinical trials ... action is important news for patients who may ...
(Date:11/24/2014)... Nov. 24, 2014  Marta Rendon, MD, founder of the ... Raton , FL and international key opinion leader in dermatology, ... the United States to attend the international ... Turkey . Here, at this gathering of over 600 ... renowned facial plastic surgery experts from Asia ...
Breaking Medicine Technology:China Nepstar Chain Drugstore Ltd. Reports Third Quarter 2014 Financial Results 2China Nepstar Chain Drugstore Ltd. Reports Third Quarter 2014 Financial Results 3China Nepstar Chain Drugstore Ltd. Reports Third Quarter 2014 Financial Results 4China Nepstar Chain Drugstore Ltd. Reports Third Quarter 2014 Financial Results 5China Nepstar Chain Drugstore Ltd. Reports Third Quarter 2014 Financial Results 6China Nepstar Chain Drugstore Ltd. Reports Third Quarter 2014 Financial Results 7China Nepstar Chain Drugstore Ltd. Reports Third Quarter 2014 Financial Results 8China Nepstar Chain Drugstore Ltd. Reports Third Quarter 2014 Financial Results 9China Nepstar Chain Drugstore Ltd. Reports Third Quarter 2014 Financial Results 10China Nepstar Chain Drugstore Ltd. Reports Third Quarter 2014 Financial Results 11Juno T Cell Therapy For Leukemia Granted FDA Breakthrough Therapy Designation 2Juno T Cell Therapy For Leukemia Granted FDA Breakthrough Therapy Designation 3Marta Rendon, MD Selected To Attend Prestigious, Global Aesthetic Experts Summit! 2Marta Rendon, MD Selected To Attend Prestigious, Global Aesthetic Experts Summit! 3
Cached News: