HOME >> MEDICINE >> NEWS
UCSD researcher wins grant to study colon cancer in African-Americans

The California Cancer Research Program (CRP) of the state Department of Health Services has awarded a physician-scientist at University of California, San Diego (UCSD) a $600,000 grant to conduct a 3-year study of colon cancer in African-Americans.

John Carethers, M.D., assistant professor of medicine at UCSD School of Medicine and member of the UCSD Cancer Center, received the highest score possible in the granting process. There were 92 grants funded out of 302 applications submitted.

With this grant, Carethers and colleagues will study tissue samples from African-American colon cancer patients to determine the incidence and impact of a particular chromosomal abnormality, called microsatellite instability (MSI). This abnormality is associated with colorectal cancer development, particularly the more virulent types. African-Americans seem to suffer from a more aggressive form of the disease compared to whites.

"When compared to statistics for whites, African-Americans have only a slightly higher incidence of colorectal cancer, but they have much higher death rates," said Carethers. "We believe MSI may play an important role."

Preliminary research in Carethers' laboratory has shown that cells with this abnormality do not respond to the widely used chemotherapeutic agent 5-fluoruracil (5-FU). The researchers will now further test this observation by studying the medical records of patients who received 5-FU treatment and whose tissue tested positive for microsatellite instability.

Also, the team will study the genes mutated by microsatellite instability to determine if they might be useful in predicting a given tumor's potential for metastasis.

"The new insights gained from this work may reveal the need for new screening strategies and new chemotherapeutic agents," said Carethers. "In addition, we hope to gain a clearer understanding of tumor formation that will benefit all patients."

Every year, approximately 149,000 people in
'"/>

Contact: Nancy Stringer
nstringer@ucsd.edu
619-543-6163
University of California - San Diego
4-Jun-2000


Page: 1 2

Related medicine news :

1. U of M researcher says Viagra may cause permanent vision loss in some men
2. Indiana University researchers closer to helping hearing-impaired using stem cells
3. Protein that helps skin cancer spread identified by Stanford researchers
4. US life expectancy about to decline, researchers say
5. Gene for age-related macular degeneration discovered by Yale researchers
6. Dartmouth researchers find where musical memories are stored in the brain
7. Columbia researchers receive $3 million to combat genetic killer of infants & toddlers
8. US cancer researchers launch first American-Israeli cancer conference
9. Mayo Clinic researcher calls for improved newborn screening
10. Hard choices: Pitt researcher presents findings on when to accept organ transplants
11. Brain-scanning technologies need standards, according to Stanford researcher

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: UCSD researcher wins grant study colon cancer African Americans

(Date:8/27/2015)... ... 2015 , ... In mid-May, Logistics Trust, Inc. (“Logistics Trust”) ... of its Doobster platform, a HIPAA-compliant mobile application that allows medical marijuana patients ... and tablets. Well, Doobster, “The App That Delivers!” is here! You ...
(Date:8/27/2015)... ... ... The Naderi Center is proud to announce that its own Dr. Jessica ... fat. The first and only Food and Drug Administration (FDA) approved treatment for ... only Board Certified surgeon in the D.C., Maryland, Virginia area to offer this innovative, ...
(Date:8/27/2015)... ... August 27, 2015 , ... Zensah®, ... Glushko, professional Tennis player for Israel in the Women’s Tennis Association (WTA). Glushko ... her training and recovery. , With a focus on technology and comfort, Zensah® ...
(Date:8/27/2015)... OKLAHOMA CITY, OK (PRWEB) , ... August 27, ... ... Partners (“GPP”) I, LP portfolio company and leading biopharmaceutical contract development manufacturing company ... acquired by Hepalink USA Inc. (“Hepalink”) for $205.68M in cash. , ...
(Date:8/27/2015)... , ... August 27, 2015 , ... Susan Harris ... procedure to relieve vaginal discomfort due to pre- and post-menopause, chemotherapy, and child birth. ... CO2 laser, which delivers controlled energy to the vaginal tissue, revitalizing cells so they ...
Breaking Medicine News(10 mins):Health News:Doobster Launches a Nationwide, Comprehensive On-Demand Medical Marijuana App 2Health News:Doobster Launches a Nationwide, Comprehensive On-Demand Medical Marijuana App 3Health News:Doobster Launches a Nationwide, Comprehensive On-Demand Medical Marijuana App 4Health News:Doobster Launches a Nationwide, Comprehensive On-Demand Medical Marijuana App 5Health News:Noninvasive Double Chin Elimination Now Available in Herndon and Chevy Chase 2Health News:Noninvasive Double Chin Elimination Now Available in Herndon and Chevy Chase 3Health News:Zensah® Compression Announces Partnership with WTA Tennis Professional Athlete, Julia Glushko 2Health News:Zensah® Compression Announces Partnership with WTA Tennis Professional Athlete, Julia Glushko 3Health News:Great Point Partners, LLC Announces that Hepalink USA Inc. Agrees to Acquire Cytovance Biologics, Inc. 2Health News:Great Point Partners, LLC Announces that Hepalink USA Inc. Agrees to Acquire Cytovance Biologics, Inc. 3Health News:Great Point Partners, LLC Announces that Hepalink USA Inc. Agrees to Acquire Cytovance Biologics, Inc. 4Health News:LifeStream Health Centre & MedSpa Announces New Treatment for Vaginal Discomfort 2Health News:LifeStream Health Centre & MedSpa Announces New Treatment for Vaginal Discomfort 3
(Date:8/27/2015)... , Aug. 27, 2015 Major pharmaceutical and ... at a legal conference in Philadelphia ... emerging issues, Tom Hagy of HB Litigation Conferences ... event, visit HB,s website at http://litigationconferences.com/?p=31886 ... Segal McCambridge Singer & Mahoney and Michelle Hart Yeary ...
(Date:8/27/2015)... 27, 2015 Itamar Medical Ltd. ... investment in public equity (PIPE) deal, in which Viola ... Itamar Medical.   Through this deal, Viola ... Medical and will work closely with the company,s management ... to the investment agreement, Itamar Medical will issue shares ...
(Date:8/27/2015)... , August 27, 2015 ... Persistence Market Research titled "Global Market Study on ... Growth by 2021", the urinary catheters market is expected to ... of 2015. It is anticipated to expand at ... reach US$1,755.0 Mn by 2021. View ...
Breaking Medicine Technology:Pharmaceutical, Medical Device Law Seminar Features In-House, Outside Counsel 2Pharmaceutical, Medical Device Law Seminar Features In-House, Outside Counsel 3Viola Private Equity Invests up to $28.4 Million in Itamar Medical and Becomes the Largest Shareholder of the Company 2Viola Private Equity Invests up to $28.4 Million in Itamar Medical and Becomes the Largest Shareholder of the Company 3Viola Private Equity Invests up to $28.4 Million in Itamar Medical and Becomes the Largest Shareholder of the Company 4Viola Private Equity Invests up to $28.4 Million in Itamar Medical and Becomes the Largest Shareholder of the Company 5Global Urinary Catheters Market Will Reach US$1,755.0 Mn by 2021: Persistence Market Research 2Global Urinary Catheters Market Will Reach US$1,755.0 Mn by 2021: Persistence Market Research 3Global Urinary Catheters Market Will Reach US$1,755.0 Mn by 2021: Persistence Market Research 4
Cached News: