HOME >> MEDICINE >> NEWS
UCSD researchers decipher function of blood-brain barrier in bacterial meningitis

The first line of defense used by the human blood-brain barrier in response to bacterial meningitis is described by researchers at the University of California, San Diego (UCSD) School of Medicine in a study published in the September 2, 2003 issue of The Journal of Clinical Investigation. The scientists also describe two bacterial factors specific to the meningitis pathogen that thwart the normal protective role of the blood-brain barrier, leading to serious infection.

Composed of a layer of blood vessels called brain microvascular endothelial cells (BMEC), the blood-brain barrier separates the brain and its surrounding tissues from the circulating blood, tightly regulating the flow of nutrients and molecules and thereby maintaining the proper biochemical conditions for normal brain function.

Bacterial meningitis, a serious brain infection, can develop rapidly into a life-threatening infection even in previously healthy children or adults. Bacteria-producing meningitis enter the human bloodstream, are carried toward the brain, and somehow manage to cross the defensive line of the blood-brain barrier.

Using an experimental blood-brain barrier established by growing layers of human BMEC in tissue culture plates, the UCSD team observed that a specific set of 80 genes in the blood-brain barrier were activated when exposed to the pathogen Group B Streptococcus (GBS), the leading cause of bacterial meningitis in human newborn infants. These genes released proteins that mobilized human white blood cells called neutrophils, which are attracted to sites of infection.

Lead author Kelly Doran, Ph.D., assistant adjunct professor of pediatrics in the UCSD Division of Infectious Diseases, said "these findings demonstrate a novel function of the blood-brain barrier, to act as a sentry that detects the threat of a bacterial pathogen and responds by triggering an immune response to clear the infection."

According to senior author V
'"/>

Contact: Sue Pondrom
spondrom@ucsd.edu
619-543-6163
University of California - San Diego
2-Sep-2003


Page: 1 2 3

Related medicine news :

1. Indiana University researchers closer to helping hearing-impaired using stem cells
2. Protein that helps skin cancer spread identified by Stanford researchers
3. US life expectancy about to decline, researchers say
4. Gene for age-related macular degeneration discovered by Yale researchers
5. Dartmouth researchers find where musical memories are stored in the brain
6. Columbia researchers receive $3 million to combat genetic killer of infants & toddlers
7. US cancer researchers launch first American-Israeli cancer conference
8. USC dental researchers develop first test for predicting cavities in children
9. Young blood revives aging muscles, Stanford researchers find
10. Uric acid may help reduce effects of spinal cord injury, Jefferson researchers find
11. Age should not be a factor in determining heart transplantation eligibility, researchers say

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/17/2018)... , ... August 17, 2018 , ... ... today announced that it is introducing its new MedAttentive Solution at the ... offerings by delivering customized alerts and notices that follow patients through all points ...
(Date:8/17/2018)... ... August 17, 2018 , ... Inc. magazine today ... most prestigious ranking of the nation’s fastest-growing private companies. The list represents a ... segment—its independent small businesses. Microsoft, Dell, Domino’s Pizza, Pandora, Timberland, LinkedIn, Yelp, Zillow, ...
(Date:8/17/2018)... ... August 17, 2018 , ... Charles E. Crutchfield III, ... patient, Haps, a sand tiger shark, to help with his scoliosis (abnormal curvature of ... well as in human care, can develop scoliosis. Some types of scoliosis are caused ...
(Date:8/15/2018)... ... August 15, 2018 , ... Today David Hyde Apparel ... , Born out of a desire for confidence and comfort year-round, the ... body odor – even in the hottest, most humid of climates. , The brainchild ...
(Date:8/15/2018)... ... August 15, 2018 , ... ... Psy.D., BCBA-D, to associate editor of Behavior Analysis in Practice, one of the ... the chief clinical standards and research officer for Trumpet, leading the company’s research ...
Breaking Medicine News(10 mins):
(Date:8/15/2018)... Pa. (PRWEB) , ... August 15, 2018 , ... ... Health officials today broke ground on a new full-service hospital in Pine ... to the residents of Pittsburgh’s northern suburbs. , Expected to open ...
(Date:8/15/2018)... ... , ... Help Your Diabetes (HYD) is a Patent Pending, Internationally known, Natural, ... their medication, working in conjunction with their primary physician. , The Founder/CEO, Dr. ... of "Imagine Living Without Type 2 Diabetes. Dr. Hockings has given over 240 diabetes ...
(Date:8/15/2018)... RAPIDS, Mich. (PRWEB) , ... August 15, 2018 ... ... an addition to their expansive lineup of casters. The newly designed Diamond ... of movement and stability. Manufactured with an antimicrobial compound injected into a ...
Breaking Medicine Technology:
Cached News: