HOME >> MEDICINE >> NEWS
UCSD researchers determine fibrin depletion decreases multiple sclerosis symptoms

Tissue damage due to Multiple Sclerosis (MS) is reduced and lifespan lengthened in mouse models of the disease when a naturally occurring fibrous protein called fibrin is depleted from the body, according to researchers at the University of California, San Diego (UCSD) School of Medicine.

The study, reported online the week of April 19, 2004 in the Proceedings of the National Academy of Sciences, identifies fibrin as a potential target for therapeutic intervention in the disease, which affects an estimated one million people worldwide.

However, the research team cautions that fibrin plays an important role in blood clotting and systemic fibrin depletion could have adverse effects in a chronic disease such as MS. Therefore, additional research is needed to specifically target fibrin in the nervous system, without affecting its ability as a blood clotting protein.

"Multiple sclerosis is a nervous system disease with vascular damage, resulting from the leakage of blood proteins, including fibrin, into the brain," said the study's first author, Katerina Akassoglous, Ph.D., a UCSD School of Medicine assistant professor of pharmacology. "Our study shows that fibrin facilitates the initiation of the inflammatory response in the nervous system and contributes to nerve tissue damage in an animal model of the disease."

MS is an autoimmune disease that affects the central nervous system (CNS), causing a variety of symptoms including loss of balance and muscle coordination, changes in cognitive function, slurred speech, bladder and bowel dysfunction, pain, and diminished vision. While the exact cause of MS is unknown, a hallmark of the disease is the loss of a material called myelin that coats nerve fibers, and the inability of the body's natural processes to repair the damage.

Although fibrin is best known for its important role in blood clotting, recent studies have shown that fibrin accumulates in the damaged nerves of MS patient
'"/>

Contact: Sue Pondrom
spondrom@ucsd.edu
619-543-6163
University of California - San Diego
19-Apr-2004


Page: 1 2 3

Related medicine news :

1. Indiana University researchers closer to helping hearing-impaired using stem cells
2. Protein that helps skin cancer spread identified by Stanford researchers
3. US life expectancy about to decline, researchers say
4. Gene for age-related macular degeneration discovered by Yale researchers
5. Dartmouth researchers find where musical memories are stored in the brain
6. Columbia researchers receive $3 million to combat genetic killer of infants & toddlers
7. US cancer researchers launch first American-Israeli cancer conference
8. USC dental researchers develop first test for predicting cavities in children
9. Young blood revives aging muscles, Stanford researchers find
10. Uric acid may help reduce effects of spinal cord injury, Jefferson researchers find
11. Age should not be a factor in determining heart transplantation eligibility, researchers say

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/23/2020)... ... January 23, 2020 , ... ... memory impairment, has announced the Best Memory Care Facilities in Pensacola, Florida. The ... features and amenities. , According to the Alzheimer’s Association , 5.6 ...
(Date:1/23/2020)... , ... January 23, 2020 , ... ... brief demonstrating that in 2019, the Trump Administration dramatically expanded upon discriminatory, ... well-being of LGBTQIA+ people in America and around the world. , “During Donald ...
(Date:1/23/2020)... , ... January 23, 2020 , ... ... filled and delivered, officially launched in Orange County today with the grand opening ... prescriptions in a fraction of the time of a traditional pharmacy. NowRx ...
(Date:1/22/2020)... ... January 22, 2020 , ... “In preparation for our ... foundational systems,” said Bill Schnittker, LIDP Founder and CEO. “We introduced Titanium, a ground-breaking, ... new claims processing systems suite. In 2019 LIDP launched CSR and Agent Portals.” ...
(Date:1/10/2020)... ... January 10, 2020 , ... Ziegler, a specialty ... to Radiology Ltd. on its partnership with US Radiology Specialists (“USRS”), backed by ... Radiology Ltd. is the largest private practice radiology group and outpatient imaging operator ...
Breaking Medicine News(10 mins):
(Date:1/22/2020)... ... January 22, 2020 , ... Biodex Medical ... to U.S. customers. A total redesign of their legacy software, the modern interface ... and intuitive navigation, while maintaining the testing and training accuracy they expect from ...
(Date:1/22/2020)... ... 2020 , ... Somatus, the market leader in providing value-based ... today announced it is expanding its renal management partnership with BlueCross BlueShield of ... kidney disease (CKD). This partnership previously only served BCBST’s Medicare Advantage members with ...
(Date:1/22/2020)... BRUNSWICK, N.J. (PRWEB) , ... January 22, 2020 , ... ... Patent (US 10,500,240) on Terminalia chebula. This newly granted patent expands Natreon’s strong patent ... trials. , The primary claim in this patent is, “a method of treating ...
Breaking Medicine Technology:
Cached News: