HOME >> MEDICINE >> NEWS
UCSD researchers determine mechanism for degradation of G proteins

Researchers at the University of California, San Diego (UCSD) School of Medicine have identified a previously unknown component of the body's cellular garbage disposal called the ubiquitin system, which is responsible for regulation of cell function by removal of abnormal and unneeded proteins.

Published in the July 8, 2003 issue of Proceedings of the National Academy of Sciences, the study provides the first description of a molecule called GAIP interacting protein N terminus (GIPN) that plays a key role in the degradation of G proteins, which are switches that turn activities on or off in the cell.

Senior author Marilyn Farquhar, Ph.D., a UCSD professor and chair of the Department of Cellular and Molecular Medicine, noted the findings should be of interest to the pharmaceutical industry since G proteins regulate everything from hormone secretion to the beating of the heart.

The researchers found that GIPN appears to specifically target G proteins for degradation and thereby regulates G protein signaling by controlling the amount of G protein expressed in the cell. This occurs via GIPN binding to the N terminus of G alpha interacting proteins (GAIP), which is the mechanism that sets the ubiquitin system in motion.

The ubiquitin system is used extensively by the cell for the turnover and degradation of proteins in both the cytoplasm, the material surrounding the nucleus, and in cell membranes. Ubiquitin, itself, is a small peptide tag that marks a protein for destruction. The interaction of GIPN and GAIP, which was also discovered by the UCSD team, is part of the machinery that places the little ubiquitin tag on a protein.

A source of study by numerous research labs, the ubiquitin system is crucial for nearly every significant activity in the cell. Although this system of protein turnover was first identified in the 1930s, the molecular mechanisms responsible for the process have remained largely unknown.

Ubiquiti
'"/>

Contact: Sue Pondrom
spondrom@ucsd.edu
619-543-6163
University of California - San Diego
22-Jul-2003


Page: 1 2

Related medicine news :

1. Indiana University researchers closer to helping hearing-impaired using stem cells
2. Protein that helps skin cancer spread identified by Stanford researchers
3. US life expectancy about to decline, researchers say
4. Gene for age-related macular degeneration discovered by Yale researchers
5. Dartmouth researchers find where musical memories are stored in the brain
6. Columbia researchers receive $3 million to combat genetic killer of infants & toddlers
7. US cancer researchers launch first American-Israeli cancer conference
8. USC dental researchers develop first test for predicting cavities in children
9. Young blood revives aging muscles, Stanford researchers find
10. Uric acid may help reduce effects of spinal cord injury, Jefferson researchers find
11. Age should not be a factor in determining heart transplantation eligibility, researchers say

Post Your Comments:
(Date:12/21/2014)... December 22, 2014 In this ... segmented by power source, product, and application. The ... battery-powered, and pneumatic instruments. By product, the market ... accessories segments. The handpieces market is further subdivided ... suction coagulators, laparoscopic instruments, shavers, wire/pin drivers, and ...
(Date:12/21/2014)... 22, 2014 BellasDress.com offers a wide ... women. Today, it announces its BellasDress Christmas Sale ... its online store. , BellasDress is a famous online ... its fans through a series of promotions. The dress ... customer. , “We are proud of offering high ...
(Date:12/21/2014)... December 21, 2014 AngelWeddingDress.com’s new collection ... is a total of 1,000 new designs in this ... coming spring 2015. , AngelWeddingDress.com promises to ... shoppers with wardrobe essentials while many fashion trends come ... the customer service team at AngelWeddingDress.com is ready to ...
(Date:12/21/2014)... Recently, one of the best prom dresses online ... has introduced its new collection of 2015 prom dresses, ... all its prom dresses & other fashionable designs, up ... top quality dress products and great customer services to ... of the best prom dresses online shops around the ...
(Date:12/21/2014)... California (PRWEB) December 21, 2014 Serious ... search for Vintage 1967 Jm Morrison and the Doors International ... posters. This would also be the only time that ... concert was on Nov. 25, 1967. According to Hawley, ... D.C. They did play the Alexandria Roller Rink earlier ...
Breaking Medicine News(10 mins):Health News:Global Powered Surgical Instruments Market Hit to $2.1 billion by 2019 - New Research Report by MarketsandMarkets 2Health News:Global Powered Surgical Instruments Market Hit to $2.1 billion by 2019 - New Research Report by MarketsandMarkets 3Health News:Global Powered Surgical Instruments Market Hit to $2.1 billion by 2019 - New Research Report by MarketsandMarkets 4Health News:BellasDress.com Announces its BellasDress Christmas Sale 2Health News:2015 Spring Wedding Dresses From AngelWeddingDress Just Released 2Health News:New Prom Dresses From One Of The Best Prom Dresses Online Shops, LunaDress Prom Shop 2
(Date:12/19/2014)... INC. (NYSE: RMD ) today announced that it ... on Thursday, January 22, 2015, after the New York Stock ... be issued after 1:00 p.m. US Pacific Time and the ... future outlook. The earnings call is scheduled to ... webcast of the call can be accessed on ResMed,s Investor ...
(Date:12/19/2014)... and LYON, France , Dec. 19, ... LLY ) and Adocia (Euronext Paris: FR0011184241 – ADOC) ... an ultra-rapid insulin, known as BioChaperone Lispro, for treatment ... BioChaperone Lispro relies on Adocia,s proprietary BioChaperone® technology and ... and Adocia will develop BioChaperone Lispro with the goal ...
(Date:12/17/2014)... , December 17, 2014 Revenue ... of expenditure on research and development In the ... its revenue by two percent to EUR 4.287 billion (last ... grew by 14 percent to EUR 360 million. "Overall, 2013/14 ... Dr. Michael Kaschke , President and CEO of Carl ...
Breaking Medicine Technology:ResMed To Announce Second Quarter 2015 Results 2Lilly and Adocia Announce Alliance to Co-Develop Ultra-Rapid Insulin Based on BioChaperone Technology 2Lilly and Adocia Announce Alliance to Co-Develop Ultra-Rapid Insulin Based on BioChaperone Technology 3ZEISS Asserts its Position in Difficult Environment 2
Cached News: