HOME >> MEDICINE >> NEWS
UCSD team reviews pituitary gland development, from a common primordium to distinct cell types

Development of the anterior pituitary gland, from a common primordium in the roof of the embryonic mouth into an organ comprising multiple distinct endocrine cell types, is described by two University of California, San Diego (UCSD) School of Medicine researchers in a review published March 22, 2002 in the journal Science.

M. Geoffrey Rosenfeld, M.D., Howard Hughes Medical Institute investigator and UCSD professor, and Kathleen M. Scully, Ph.D., postdoctoral fellow, UCSD Department of Medicine, provide a step-by-step description of the intricate cell signaling and nuclear events that take place during key steps in pituitary gland development.

Lying at the base of the brain, the pituitary is a pea-sized gland that secretes hormones involved in growth, reproduction, lactation, thyroid gland function, and the maintenance of homeostasis (i.e. a constant internal environment). The gland is a complex organ regulating a combination of neural signals from the hypothalamus as well as feedback from target organs.

In recent years, researchers have begun to identify some of the molecules that direct the series of developmental steps by which precursor cells gain a pituitary identity, proliferate, and differentiate to form the distinct hormone-producing cell types of the mature gland, Scully says.

In their Science review article, the researchers describe an initial external signaling phase where cells surrounding the pituitary primordium secrete molecules that start the developmental process. Eventually, the developing gland itself begins secreting some of these molecules, which help to establish its identity and facilitate growth. During this time, expression of certain transcription factors, that function as molecular switches turning genes on and off, must be activated or repressed in order for the pituitary gland to progress to the next step in its development.

Referring to their own genetic and biochemical research, as well as w
'"/>

Contact: Sue Pondrom
spondrom@ucsd.edu
619-543-6163
University of California - San Diego
22-Mar-2002


Page: 1 2

Related medicine news :

1. Zengens new study reviews novel approach to control inflammation using melanocortin receptors
2. Drug company fees for FDA reviews havent accelerated approvals, study finds
3. Study reviews discussion of medical errors at hospital conferences
4. Prescription drug utilization reviews are less than useful
5. Expert reviews cannot be trusted
6. Budget received mixed reviews from Canadian Dental Association
7. Estrogen-driven gene activates human pituitary tumors, Cedars-Sinai Medical Center researchers find
8. Comprehensive pituitary center at Cedars-Sinai brings together under one roof medical, surgical, research and other components
9. Glitches discovered and fixed in animal study make surgery for human pituitary tumors quicker, safer and less painful
10. Leukemia drug breakthrough study in New England Journal of Medicine
11. Sunlight reduces risk of lymph gland cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/23/2019)... ... July 23, 2019 , ... Shady Grove Fertility (SGF) ... grand opening of its newest full-service fertility and in vitro fertilization (IVF) program in ... full-service location offers access to two leading, board certified reproductive endocrinologists, a state-of-the-art laboratory, ...
(Date:7/21/2019)... ... ... Surgical facelifts might be the gold standard for lifting facial skin and ... needs surgery, according to cosmetic surgeon Dr. Richard E. Buckley, medical director of MilfordMD ... who can’t tolerate the downtime associated with a surgical facelift, don’t want surgery or ...
(Date:7/18/2019)... ... July 18, 2019 , ... ... officials in Congress about new bills to protect patients from unexpected out-of-network medical ... People from Surprise Medical Bills Act ( H.R. 3502 ), introduced in the ...
(Date:7/18/2019)... ... July 18, 2019 , ... For the fourth ... Atlanta, Magazine’s list of “Top Doctors” issue. Deutsch is a double-board-certified plastic and, ... With specialized training from MD Anderson Cancer Center and Albert Einstein, Montefiore Medical ...
(Date:7/17/2019)... ... 17, 2019 , ... The FDA has cleared the "truSculpt® flex" ... to eight body areas simultaneously. Dr. Dennis Dass says the truSculpt® flex ... than previous muscle toning devices or conventional exercise. , “The truSculpt® flex is FDA-cleared ...
Breaking Medicine News(10 mins):
(Date:7/23/2019)... (PRWEB) , ... July 23, 2019 , ... ... its sixth physical rehabilitation hospital in the ever-growing Liberty Township (N. Cincinnati), Ohio ... acres, just north of Cincinnati, Ohio. The hospital site is located at the ...
(Date:7/23/2019)... ... July 23, 2019 , ... Breathe Life , a ... Hill , Partner at Diagram Ventures , has joined its board of directors. ... building and scaling early-stage technology businesses to the Breathe Life board at a time ...
(Date:7/23/2019)... ... July 23, 2019 , ... ... needs in the field of urology, today announced that Samuel Dakil, MD, Norman ... Excellence. The designation recognizes that Dr. Dakil has achieved a high level of ...
Breaking Medicine Technology:
Cached News: