UCSF Study In Rats Suggests Synthetic Drug Mimicking Marijuana Might Be Used To,,Treat Pain

Researchers at the University of California San Francisco have shown in rats that a synthetic drug that mimics the principal active ingredient in marijuana has an effect similar to that of morphine on an area of the brain that modulates pain.

The finding, reported in the September 24 issue of Nature, raises the possibility that marijuana-like drugs could be used to treat pain, said the lead author of the study, Ian Meng, PhD, a postdoctoral fellow in the laboratory of Howard Fields, PhD, a professor of neurology and physiology and a research scientist in the W.M. Keck Foundation Center for Integrative Neuroscience at UCSF.

While opioids such as morphine provide strong analgesic effects for many types of pain, they produce side effects such as nausea and respiratory depression. In contrast, marijuana, a type of cannabinoid drug, actually increases appetite. In the future, says Meng, it may be possible to use a lower dose of opioids if they are used in combination with a cannabinoid, producing fewer side effects and increasing the pain relieving effects.

The researchers focused their study on a region of the brain known as the rostral ventromedial medulla (RVM) which modulates pain by either increasing or decreasing the amount of pain signals that pass through the spinal cord. They tested the effects of the synthetic cannabinoid, WIN555, 212-2, on this region by measuring the time it took for rats to move their tails away from a heat source.

In the first experiment, rats that were given WIN55,212-2 kept their tails on the heat source much longer than rats that were not given the drug, indicating the drug reduced pain. However, after the researchers shut down the RVM, rats that were given WIN55,212-2 no longer demonstrated insensitivity to pain, moving their tails from the heat source as quickly as the rats who had not received the drug. The test demonstrated that the RVM was critical for producing the pain-relieving effects of cannabinoids.


Contact: Jennifer O'Brien
(415) 476-2557
University of California - San Francisco

Page: 1 2 3

Related medicine news :

1. Study of energy and health in Africa focuses spotlight on charcoal and forest management
2. Study shows promise in identifying kidney failure
3. Study shows patch therapy may be as effective as oral medications
4. Study shows soy is well accepted in school lunches
5. Study finds that coordinating care of chronically ill patients does not increase liability
6. Study provides new estimates of the causes of child mortality worldwide
7. Study finds factors linked to substance use disorder relapse among health care professionals
8. Study finds majority of women willing to accept cervical cancer vaccine for self and children
9. Study shows use of budesonide reduced the risk of asthma related events by 40% in children
10. Study shows risk of cardiac death after radiation for breast cancer has dramatically decreased
11. Study shows acrylamide in baked and fried food does not increase risk of breast cancer in women

Post Your Comments:

(Date:7/2/2020)... ORANGE BEACH, Ala. (PRWEB) , ... July 02, ... ... educator, recently awarded its annual Outstanding Safety Professional of the Year Award to ... members selected Simmons from more than 250 nominations. Simmons, who holds a master’s ...
(Date:7/1/2020)... ... July 01, 2020 , ... Psilera Bioscience (“Psilera”), ... analogues, announces its core executive team. The co-founders Drs. Jackie Salm and Chris ... and as distinguished researchers within the cannabis industry. They are joined by pharmaceutical ...
(Date:6/28/2020)... ... June 26, 2020 , ... PathAI, a global provider of artificial ... exploratory analysis of digital scoring of PD-L1 expression to assess response in patients treated ... the 2020 American Association for Cancer Research (AACR) Annual Meeting. AACR was held June ...
(Date:6/28/2020)... MILWAUKEE (PRWEB) , ... June 28, 2020 , ... ... allergy/immunology societies around the world, dedicates World Allergy Week, from June 28 to ... pandemic caused by SARS CoV-2. , COVID-19, short for “coronavirus disease 2019”, is ...
(Date:6/24/2020)... (PRWEB) , ... June 24, 2020 , ... Dr. Katinka ... has been the most requested guest on the True Grit and Grace podcast. She ... have hope and knowing remission is possible. , After being diagnosed with CRPS ...
Breaking Medicine News(10 mins):
(Date:6/25/2020)... ... June 25, 2020 , ... ... International Research Congress (IRC) , which is being conducted entirely online for the ... premier global platform for the discussion and dissemination of state-of-the-art research on facioscapulohumeral ...
(Date:6/24/2020)... DIEGO (PRWEB) , ... June 24, 2020 , ... The ... San Diego and Nashville. The two day courses offer providers a hands on approach ... being offered as a Virtual Live Stream for providers who wish to enroll remotely. ...
(Date:6/23/2020)... ... June 23, 2020 , ... Today Project ... of the first online COVID-19 trainings for health workers and others on the ... training entitled COVID-19 Training for Health Workers: Preparedness and Response are ...
Breaking Medicine Technology:
Cached News: