HOME >> MEDICINE >> NEWS
UCSF-led team discovers possible cancer 'susceptibility' gene

A UCSF-led team has identified a common variant of a gene known as Aurora2 that may increase susceptibility to cancer development. The finding provides one of the first examples of an elusive type of "low penetrance" tumor susceptibility gene in humans.

The results, reported in the July 27 on-line version of Nature Genetics, support the emerging viewpoint that common variant forms of some genes can contribute to cancer susceptibility, particularly when a number of these variant genes are co-inherited and therefore can act in concert.

Traditionally, advances in understanding cancer predisposition have involved discoveries of rare, inherited, full-fledged genetic mutations that dramatically increase the risk of cancer, such as the brca1 and brca2 genes in breast cancer. But scientists have come to recognize that such "high penetrance" genes account for only 5-10 percent of cancers.

Evidence from mouse models and human epidemiologic studies suggests that susceptibility to most cancers results from numerous low penetrance polymorphisms acting together to disrupt a cell's regulatory controls. In themselves, these subtle variations are not harmful. A mouse or human that inherits a mildly more active form of a certain regulatory gene such as myc or ras won't necessarily have a problem. But the evidence suggests that if either inherits a number of overly active regulatory genes that act synergistically, cancer is more likely to develop.

"It's like the components of a lock it's the combination of these polymorphisms that makes a substantial difference in susceptibility," says senior author Allan Balmain, PhD, UCSF professor of biochemistry and Barbara Bass Bakar Endowed Chair in Cancer Genetics at the UCSF Comprehensive Cancer Center. "We're trying to identify the components of the lock. The Aurora2 story is the first component we've identified."

While much evidence has suggested that cancer susceptibility genes exist in humans, id
'"/>

Contact: Jennifer OBrien
jobrien@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
27-Jul-2003


Page: 1 2 3 4

Related medicine news :

1. Mayo Clinic discovers new pathway against pancreatic cancer
2. Mayo Clinic discovers a key to low metabolism and major factor in obesity
3. Mayo Clinic discovers potential marker for aggressive kidney cancer
4. Mayo Clinic discovers one mechanism for why men and women differ in immune response
5. LSUHSC neurosurgical team discovers novel therapy for intractable hiccups
6. Mayo Clinic discovers important clue to new treatments for lymphoma, breast and colon cancers
7. Mayo Clinic discovers one more downside to alcoholism
8. Study discovers a way to keep infants safe from second-hand smoke
9. Baylor team discovers reason for heart transplant failure
10. Mayo Clinic discovers cause of a frequently fatal myasthenic syndrome affecting children
11. Rosenbaum discovers "hidden clue" on cardiogram

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/22/2020)... ... July 22, 2020 , ... Healthcare data curation ... Data Curation as a Service (DCaaS) solution for payers, providers, healthcare systems, and ... data curation parameters and are custom tailored to provide clients a clear, trusted, ...
(Date:7/18/2020)... ... July 17, 2020 , ... With government legislation stating that hospitality and retail ... wear either a mask or visor, there has been a drastic increase in demand ... has led to a spike in single-use plastic products being produced. , Due ...
(Date:7/18/2020)... ... ... When the federal government extended the Paycheck Protection Program from June 30th ... to obtain a PPP loan. But the biggest obstacle often may be that many ... are eligible. , While 4.9 million companies obtained potentially forgivable loans through PPP, ...
(Date:7/10/2020)... (PRWEB) , ... July 10, 2020 , ... ... overwhelming for people with spinal cord disease or injury and social distancing makes ... pandemic can induce symptoms of anxiety, depression, distress, and PTSD amongst our adult ...
(Date:7/10/2020)... (PRWEB) , ... July 10, 2020 , ... ... on addressing unmet needs in the field of urology, today announced that Carl ... as a UroLift® Center of Excellence. The designation recognizes that Dr. Meyer has ...
Breaking Medicine News(10 mins):
(Date:7/10/2020)... ... July 10, 2020 , ... Precision ADM, ... manufacturing solutions provider today announced that their CANSWABâ„¢ nasopharyngeal swabs are the first ... engineered a new 3D-printed swab design and has trademarked the name CANSWABâ„¢ for ...
(Date:7/10/2020)... ... 2020 , ... The Dolphin Company, the largest park ... 12 million guests, unveiled its new comprehensive plan of protocols and communication strategy: ... facets of the operation, safety, and health addressing COVID-19. , Experts developed this ...
(Date:7/10/2020)... ... 09, 2020 , ... The Urgent Care Association (UCA), College of Urgent Care ... present a virtual education on acute flaccid myelitis (AFM), an uncommon but serious condition ... CT on July 14, 2020. , AFM, which is most prevalent in children, ...
Breaking Medicine Technology:
Cached News: