HOME >> MEDICINE >> NEWS
UCSF scientists show prion shape affects nature of infection

UCSF scientists have demonstrated for the first time that a change in the folded shape of a prion protein changes its infectious properties -- including the prion's ability to jump "species barriers."

The research, based on studies of prion infectivity in yeast, solves one of the great puzzles about prions: If they are infectious proteins with no genetic material of their own and no ability to mutate genetically, how can a single prion exist in different strains that can cause different diseases? The puzzle has led some to doubt that a protein alone causes mad cow and related diseases.

To reconcile the existence of prion strains with the "protein-only" hypothesis of prion propagation, scientists had proposed that a single protein can misfold into multiple different infectious conformations: one for each different type of prion strain.

The new finding confirms this view. It shows that shape change accounts for strain differences, and it lays the groundwork for research to determine the physical differences that allow a prion to change shape and cause different diseases. Answers could lead to strategies to block the folding or its route to disease, the scientists say.

The UCSF discovery is published in the March 18 issue of Nature. A second paper in the same issue of the journal by scientists at Florida State University reaches similar conclusions.

A News and Views commentary in Nature on the two research findings concludes that the work firmly establishes the link between different prion forms and different prion strains.

A prion is thought to cause disease by inducing other proteins to adopt its contorted shape and form sheets called amyloids. UCSF's Stanley Prusiner, MD, received the 1997 Nobel Prize in Physiology or Medicine for the discovery of prions and the underlying principles of their mode of action.

Different strains of the mammalian prion play important roles in determining the degree to
'"/>

Contact: Wallace Ravven
wravven@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
17-Mar-2004


Page: 1 2 3 4

Related medicine news :

1. OHSU scientists test medication to treat involuntary weight loss
2. Earlier use of prostate cancer vaccines urged by Hopkins scientists
3. Tobacco industry pays scientists to challenge secondhand smokes link to infant death risk
4. Schepens scientists regenerate optic nerve for the first time
5. OHSU scientists develop MRI approach to improve breast cancer detection
6. UCLA neuroscientists pinpoint new function for mirror neurons
7. Jefferson scientists uncover potential trigger of diabetic kidney disease
8. Johns Hopkins scientists receive presidential medals
9. UCLA brain scientists crack mystery of how alcohol causes intoxication
10. Wisconsin scientists grow critical nerve cells
11. Jefferson scientists help explain statins effects in Alzheimers disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... , ... October 13, 2017 , ... Apple Rehab ... services, staged a mock evacuation of the facility as part of a disaster drill ... Department, Echo Hose EMS and Shelton City Emergency Manager, as well as the ...
(Date:10/13/2017)... ... October 13, 2017 , ... The Visiting Nurse Association (VNA) of Somerset Hills ... specialty vendors and unique items from across the nation, this holiday-themed event will raise ... offered by the VNA. The boutique will be open Saturday, November 4 (10:00 ...
(Date:10/13/2017)... NJ (PRWEB) , ... October 13, 2017 , ... Global ... at scenic Alexandria Park in Milford, NJ. This free event, sponsored by Global ... physical activity. The fun run is geared towards children of all ages; it ...
(Date:10/13/2017)... ... October 13, 2017 , ... Talented host, actor Rob ... sciatica in a new episode of "Success Files," which is an award-winning educational ... and investigates each subject in-depth with passion and integrity. , Sciatica occurs when ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the Mountains to ... to save lost souls in the Philippines. “The Journey: From the Mountains to the ... teacher of the Bible. She has taught all ages and currently teaches a class ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)...  Caris Life Sciences ® , a leading innovator ... precision medicine, today announced that St. Jude Medical Center,s ... (POA) as its 17 th member. Through participation ... Cancer Institute will help develop standards of care and ... making cancer treatment more precise and effective. ...
(Date:10/10/2017)... --  West Pharmaceutical Services, Inc. (NYSE: WST), a ... today shared the results of a study highlighting the ... administration of polio vaccines. The study results were presented ... by Dr. Ondrej Mach , Clinical Trials and ... and recently published in the journal Vaccine. i ...
(Date:10/4/2017)... to the Centers for Disease Control and Prevention (CDC), influenza vaccination ... is helping communities across Massachusetts , Connecticut ... flu shots through the end of the month. *Some exclusions ... ... shot is by the end of October, according to the Centers for ...
Breaking Medicine Technology:
Cached News: