HOME >> MEDICINE >> NEWS
UCSF scientists show prion shape affects nature of infection

UCSF scientists have demonstrated for the first time that a change in the folded shape of a prion protein changes its infectious properties -- including the prion's ability to jump "species barriers."

The research, based on studies of prion infectivity in yeast, solves one of the great puzzles about prions: If they are infectious proteins with no genetic material of their own and no ability to mutate genetically, how can a single prion exist in different strains that can cause different diseases? The puzzle has led some to doubt that a protein alone causes mad cow and related diseases.

To reconcile the existence of prion strains with the "protein-only" hypothesis of prion propagation, scientists had proposed that a single protein can misfold into multiple different infectious conformations: one for each different type of prion strain.

The new finding confirms this view. It shows that shape change accounts for strain differences, and it lays the groundwork for research to determine the physical differences that allow a prion to change shape and cause different diseases. Answers could lead to strategies to block the folding or its route to disease, the scientists say.

The UCSF discovery is published in the March 18 issue of Nature. A second paper in the same issue of the journal by scientists at Florida State University reaches similar conclusions.

A News and Views commentary in Nature on the two research findings concludes that the work firmly establishes the link between different prion forms and different prion strains.

A prion is thought to cause disease by inducing other proteins to adopt its contorted shape and form sheets called amyloids. UCSF's Stanley Prusiner, MD, received the 1997 Nobel Prize in Physiology or Medicine for the discovery of prions and the underlying principles of their mode of action.

Different strains of the mammalian prion play important roles in determining the degree to
'"/>

Contact: Wallace Ravven
wravven@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
17-Mar-2004


Page: 1 2 3 4

Related medicine news :

1. OHSU scientists test medication to treat involuntary weight loss
2. Earlier use of prostate cancer vaccines urged by Hopkins scientists
3. Tobacco industry pays scientists to challenge secondhand smokes link to infant death risk
4. Schepens scientists regenerate optic nerve for the first time
5. OHSU scientists develop MRI approach to improve breast cancer detection
6. UCLA neuroscientists pinpoint new function for mirror neurons
7. Jefferson scientists uncover potential trigger of diabetic kidney disease
8. Johns Hopkins scientists receive presidential medals
9. UCLA brain scientists crack mystery of how alcohol causes intoxication
10. Wisconsin scientists grow critical nerve cells
11. Jefferson scientists help explain statins effects in Alzheimers disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2016)... FL (PRWEB) , ... June 25, 2016 , ... The temporary closing of Bruton Memorial ... Plant City Observer , brings up a new, often overlooked aspect of head lice: the ... closing for fumigation is not a common occurrence, but a necessary one in the event ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, ... at Work award to iHire in recognition of their exemplary accomplishments in worksite health ... annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. ...
(Date:6/24/2016)... ... ... crisis. Her son James, eight, was out of control. Prone to extreme mood shifts and ... him, he couldn’t control his emotions,” remembers Marcy. “If there was a knife on ... say he was going to kill them. If we were driving on the freeway, ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and ... that call for a minimum wage raise to $12 an hour by 2020 and then ... will restore the lost value of the minimum wage, assure the wage floor does not ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... is actively feeding the Frederick area economy by obtaining investment capital for emerging ... the past 2½ years that have already resulted in more than a million ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... KNOXVILLE, Tenn. , June 24, 2016 /PRNewswire/ ... market providing less invasive and more durable cerebrospinal ... million in funding.  The Series-A funding is led ... the Lighthouse Fund, and other private investors.  Arkis, ... less-invasive neurosurgical instrumentation and the market release of ...
(Date:6/23/2016)... Ill. , June 23, 2016  In a startling report ... are failing their residents by lacking a comprehensive, proven plan to ... a definitive ranking of how states are tackling the worst ... to only four states – Kentucky , ... Vermont . Of the 28 failing states, three ...
(Date:6/23/2016)... 2016 Bracket , a leading clinical trial ... clinical outcomes platform, Bracket eCOA (SM) 6.0, at the ... – 30, 2016 in Philadelphia , Pennsylvania.  ... Assessment product of its kind to fully integrate with RTSM, ... eCOA 6.0 is a flexible platform for electronic clinical outcomes ...
Breaking Medicine Technology:
Cached News: