HOME >> MEDICINE >> NEWS
UCSF study offers insight into human circadian rhythms

particular family, the first report of a human circadian rhythm gene. (Science, Jan. 12, 2001).

The breadth of the knowledge coming out of the current study is somewhat unique, says Ptaceck. "I'm not aware of another study that has gone from the human to the fly to the mouse in a single study. It demonstrates of the combined power of human molecular genetics research and studies in animals."

The study began with the scientists isolating, or cloning, the mutant gene responsible for causing FASPS in five members of an extended family. The gene is known as casein kinase1 delta (ck1 delta); the mutated form is designated CK1 delta-T44A. They made the discovery by taking blood samples of the individuals and then using linkage analysis to hone in on the region of DNA within the chromosomes most likely to reveal the relevant gene, based on what was known about other genetic markers related to circadian rhythms. The gene was found on chromosome 17. (The mutated form was compared to the gene in family members who did not have FASPS.)

Next, they determined that, in a test tube, the activity of the enzyme (CK1 delta) encoded by the mutated gene was decreased.

Finally, to explore the effect of the genetic mutation on circadian activity, the scientists inserted the mutated human gene into the nerve cells of the circadian clock in the fruit fly Drosophila melanogaster and the mouse. Scientists have learned much about human gene function by studying animals, given the many genes that have been conserved through evolution, and both animals have been a key source of information regarding the genetic and molecular biology of circadian rhythms.

As expected, the transgenic mice displayed the same abnormal sleeping pattern seen in the human cases of FASPS, as measured in the decrease in their wheel-running activity.

Unexpectedly, however, the result was the opposite in the transgenic flies, as displayed by its extended locomotor activity.
'"/>

Contact: Jennifer O'Brien
jobrien@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
30-Mar-2005


Page: 1 2 3 4

Related medicine news :

1. First head-to-head study to compare lidoderm patch and Celebrex in treating pain
2. UMaine study looks at infants and chronic nighttime crying
3. Chronic pain treatments more effective when taken together, new study shows
4. UNC study: Most N.C. family practitioners engage in unrecognized community service
5. New study in Nature demonstrates protection against cell death during heart attack
6. International breast cancer prevention study launches in the United States and Canada
7. UW study shows blacks and Latinos are more satisfied with physicians of the same race
8. Physicians may not be accurate in their confidence levels of their diagnoses, says Pitt study
9. Advertising by academic medical centers may risk eroding public trust, says study
10. Fat may promote inflammation, new study suggests
11. Bullying among sixth graders a daily occurrence, UCLA study finds

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Apple ... care services, staged a mock evacuation of the facility as part of a disaster ... Fire Department, Echo Hose EMS and Shelton City Emergency Manager, as well as the ...
(Date:10/13/2017)... ... October 13, 2017 , ... Ellevate Network, the leading network ... advocate for action towards gender equality at their inaugural Summit in New York City ... and reached a social audience of over 3 million. To watch the Mobilize Women ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... viewers the lowdown on sciatica in a new episode of "Success Files," which ... current events and innovation and investigates each subject in-depth with passion and integrity. ...
(Date:10/13/2017)... ... ... On The Brink”: the Christian history of the United States and the loss of ... William Nowers. Captain Nowers and his wife, Millie, have six children, ten grandchildren, ... Navy. Following his career as a naval aviator and carrier pilot, he spent ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest and fastest ... to open a flagship location in Covington, LA at 401 N. U.S. Highway 190, ... next to Office Depot in the Holiday Square shopping center. Its location allows it ...
Breaking Medicine News(10 mins):
(Date:9/19/2017)... Mich. , Sept. 19, 2017 HistoSonics, Inc., a venture-backed medical device company ... destruction of targeted tissues, announced three leadership team developments today:   ... PhD ... ... Veteran medical device executive Josh ...
(Date:9/18/2017)... , Sept. 18, 2017  PMD Healthcare of ... Pharmacy of Kalamazoo, Mich. , have ... service that expedites and streamlines patient and provider access ... 2.0, and wellness management services.  ... used to measure lung function for a variety of ...
(Date:9/13/2017)... --  OrthoAtlanta has been named the official orthopedic and ... for the 2018 College Football Playoff (CFP) National Championship to ... in Atlanta, Georgia . OrthoAtlanta is proud ... participating in many activities leading up to, and including the ... ...
Breaking Medicine Technology:
Cached News: