HOME >> MEDICINE >> NEWS
UCSF study offers insight into human circadian rhythms

particular family, the first report of a human circadian rhythm gene. (Science, Jan. 12, 2001).

The breadth of the knowledge coming out of the current study is somewhat unique, says Ptaceck. "I'm not aware of another study that has gone from the human to the fly to the mouse in a single study. It demonstrates of the combined power of human molecular genetics research and studies in animals."

The study began with the scientists isolating, or cloning, the mutant gene responsible for causing FASPS in five members of an extended family. The gene is known as casein kinase1 delta (ck1 delta); the mutated form is designated CK1 delta-T44A. They made the discovery by taking blood samples of the individuals and then using linkage analysis to hone in on the region of DNA within the chromosomes most likely to reveal the relevant gene, based on what was known about other genetic markers related to circadian rhythms. The gene was found on chromosome 17. (The mutated form was compared to the gene in family members who did not have FASPS.)

Next, they determined that, in a test tube, the activity of the enzyme (CK1 delta) encoded by the mutated gene was decreased.

Finally, to explore the effect of the genetic mutation on circadian activity, the scientists inserted the mutated human gene into the nerve cells of the circadian clock in the fruit fly Drosophila melanogaster and the mouse. Scientists have learned much about human gene function by studying animals, given the many genes that have been conserved through evolution, and both animals have been a key source of information regarding the genetic and molecular biology of circadian rhythms.

As expected, the transgenic mice displayed the same abnormal sleeping pattern seen in the human cases of FASPS, as measured in the decrease in their wheel-running activity.

Unexpectedly, however, the result was the opposite in the transgenic flies, as displayed by its extended locomotor activity.
'"/>

Contact: Jennifer O'Brien
jobrien@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
30-Mar-2005


Page: 1 2 3 4

Related medicine news :

1. First head-to-head study to compare lidoderm patch and Celebrex in treating pain
2. UMaine study looks at infants and chronic nighttime crying
3. Chronic pain treatments more effective when taken together, new study shows
4. UNC study: Most N.C. family practitioners engage in unrecognized community service
5. New study in Nature demonstrates protection against cell death during heart attack
6. International breast cancer prevention study launches in the United States and Canada
7. UW study shows blacks and Latinos are more satisfied with physicians of the same race
8. Physicians may not be accurate in their confidence levels of their diagnoses, says Pitt study
9. Advertising by academic medical centers may risk eroding public trust, says study
10. Fat may promote inflammation, new study suggests
11. Bullying among sixth graders a daily occurrence, UCLA study finds

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... ... Talented host, actor Rob Lowe, is introducing a segment ... of "Success Files," which is an award-winning educational program broadcasted on PBS Member ... with passion and integrity. , Sciatica occurs when the sciatic nerve in the ...
(Date:10/12/2017)... ... October 12, 2017 , ... First Healthcare Compliance (FHC), ... will showcase a range of technology and learning solutions at the 68th Annual ... Expo to be held October 14–18, 2017 at the Mandalay Bay Resort in ...
(Date:10/12/2017)... PALM CITY, Fla. (PRWEB) , ... October 12, 2017 , ... ... of cold therapy products, announced today the introduction of an innovative new design of ... the multipurpose pad so you get maximum comfort while controlling your pain while using ...
(Date:10/12/2017)... LOS ANGELES (PRWEB) , ... October 12, 2017 ... ... of Parsa Mohebi Hair Restoration, has recently contributed a medical article to the ... doctors, on cosmetictown.com. Dr. Mohebi’s article spotlights the hair transplant procedure known as ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... one of Michigan’s 2017 Best and Brightest in Wellness® by Best and Brightest. ... awards program on Friday, Oct. 20 from 7:30 a.m. to 2 p.m. at ...
Breaking Medicine News(10 mins):
(Date:9/22/2017)... AVACEN Medical (AVACEN) announced that its CE-Marked ... those with the widespread pain associated with fibromyalgia in ... Essex, England commented, "I had ... no sleep at all, tremendous pain, with every movement ... [the AVACEN 100] enough, how this has and is ...
(Date:9/18/2017)... , Sept. 18, 2017 ... fields of bioinformatics and immune engineering, today ... protective avian influenza A (H7N9) vaccine. ... related to seasonal influenza and presents a ... on prior exposure to be effective. Using ...
(Date:9/12/2017)... 2017  ValGenesis Inc., the global leader in ... to announce the appointment of Dr. Ajaz ... of Directors and Chairman of Advisory Board beginning ... companies to manage their entire validation lifecycle process ... this process. Furthermore, ValGenesis VLMS enables rigorous compliance, ...
Breaking Medicine Technology:
Cached News: