HOME >> MEDICINE >> NEWS
UI findings indicate DNA methylation process may lead to oral cancer

IOWA CITY, Iowa--Just like a light switch, a process known as cytosine methylation can turn off expression of tumor suppressor genes and lead to oral cancer, according to University of Iowa Health Care research findings.

"During cancer development, the normal control of cytosine methylation is lost, and DNA can become aberrantly methylated," explained Frederick Domann, Ph.D., UI associate professor of radiology. "When this happens to a tumor suppressor gene, it switches off its expression and contributes to cancer progression."

For some time now, cancer researchers have focused on tumor suppressor genes in an attempt to answer the question of how cancer grows and spreads. When they work properly, tumor suppressor genes do just what their name suggests: They suppress cancer. However, if something disrupts the genes, the cancer grows and stretches into other areas of the body.

Classical genetics has shown that mutations and deletions of these tumor suppressor genes contribute to malignancy. However, another mechanism, DNA methylation, can inactivate tumor gene expression as well, Domann said. This methylation phenomenon is the focus of Domann's lab investigations. Methylation is the addition of single carbon atoms to specific target sites within the DNA.

Cytosine, one of the four nucleotides in DNA, is the only base that can be methylated normally by a cell's enzymatic machinery. Cytosine is normally methylated in cells at certain positions and not others. Carcinogenesis alters the pattern of cytosine methylation, which contributes to altered patterns of gene expression in cancer.

Based on the interest of one of his then post-doctoral fellows, D. Thane Cody II, M.D., currently assistant professor of surgery at Southern Illinois University, Domann and his team began investigating whether aberrant methylation contributed to oral cancer tumors. There were more than 28,000 news cases of oral cancer in the United States in 1995, resulting in more
'"/>

Contact: Jennifer Cronin
jennifer-cronin@uiowa.edu
319-335-9917
University of Iowa
4-Oct-1999


Page: 1 2 3

Related medicine news :

1. Statement on the findings of the Womens Health Study
2. Latest findings on genetic blood disorder Cooleys Anemia
3. Hard choices: Pitt researcher presents findings on when to accept organ transplants
4. Contrary to previous findings, smoking is detrimental to patients with Alzheimers
5. Medical meeting to feature research findings and disease prevention and health promotion sessions
6. New findings on patient safety at childrens hospitals
7. Nerve navigation findings prompt new direction for spinal cord research
8. Testosterone may help in recovery from strokes, suggests preliminary findings in study
9. Study findings question claims of significant savings from pharmacy dose consolidation programs
10. Some positive findings in new study on cocaine exposed children
11. Novel findings about neovessel formation

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: findings indicate DNA methylation process may lead oral cancer

(Date:7/31/2014)... Thousands of independent community pharmacists, industry ... come together today to kick off ThoughtSpot 2014, ... "ThoughtSpot 2014 is Good Neighbor Pharmacy’s annual conference ... help their businesses thrive," stated AJ Caffentzis, President, ... commitment to independent community pharmacies, and at ThoughtSpot, ...
(Date:7/31/2014)... San Francisco, California (PRWEB) July 31, 2014 ... systems is expected to reach USD 37.83 billion ... Grand View Research, Inc. Increasing geriatric population base ... such as cardiovascular, orthopedic, and respiratory diseases coupled ... drive market growth over the next six years. ...
(Date:7/31/2014)... By Steven Reinberg ... (HealthDay News) -- Strict regulation of electronic cigarettes isn,t ... says. On the contrary, allowing e-cigarettes to compete ... the researchers concluded after reviewing 81 prior studies on ... "Current evidence suggests that there is a ...
(Date:7/31/2014)... (PRWEB) July 31, 2014 ... to reach $702m by 2020, increasing slowly ... market will be driven by: the rising ... incurred by government agencies, such as Medicare, ... adoption of innovative technologies such as flow ...
(Date:7/31/2014)... for those with periodontal disease related to type 2 diabetes, ... report appearing in the August 2014 issue of the ... most important blood cells involved in the human immune response, ... in type 2 diabetes-associated periodontal disease. These findings support ... cells may treat or prevent this complication. , "Our ...
Breaking Medicine News(10 mins):Health News:Good Neighbor Pharmacy’s ThoughtSpot Begins Today with Record Attendance 2Health News:Good Neighbor Pharmacy’s ThoughtSpot Begins Today with Record Attendance 3Health News:Medical Imaging Systems - Global Industry Trends, Size, Share, Opportunity, Growth, Outlook, Segmentation and Forecast from 2014 to 2020 - Grand View Research, Inc. 2Health News:Medical Imaging Systems - Global Industry Trends, Size, Share, Opportunity, Growth, Outlook, Segmentation and Forecast from 2014 to 2020 - Grand View Research, Inc. 3Health News:Medical Imaging Systems - Global Industry Trends, Size, Share, Opportunity, Growth, Outlook, Segmentation and Forecast from 2014 to 2020 - Grand View Research, Inc. 4Health News:Medical Imaging Systems - Global Industry Trends, Size, Share, Opportunity, Growth, Outlook, Segmentation and Forecast from 2014 to 2020 - Grand View Research, Inc. 5Health News:Medical Imaging Systems - Global Industry Trends, Size, Share, Opportunity, Growth, Outlook, Segmentation and Forecast from 2014 to 2020 - Grand View Research, Inc. 6Health News:Benefits of E-Cigarettes May Outweigh Harms, Study Finds 2Health News:Benefits of E-Cigarettes May Outweigh Harms, Study Finds 3Health News:US Neurovascular Interventions Market Worth $702m by 2020 Says a New Report Available at MarketOptimizer.org 2Health News:US Neurovascular Interventions Market Worth $702m by 2020 Says a New Report Available at MarketOptimizer.org 3Health News:US Neurovascular Interventions Market Worth $702m by 2020 Says a New Report Available at MarketOptimizer.org 4Health News:US Neurovascular Interventions Market Worth $702m by 2020 Says a New Report Available at MarketOptimizer.org 5Health News:Researchers uncover cause of gum disease related to type 2 diabetes 2
(Date:7/31/2014)... NOTTINGHAM, England , July 31, 2014 /PRNewswire/ ... ) today announced that its subsidiary, Molecular Profiles ... that will support pharmaceutical and biotech drug developers ... Profiles, pharmaceutical development services will be supported by ... (DMPK) to give clients a smarter route into ...
(Date:7/31/2014)... RESEARCH TRIANGLE PARK, N.C. , July 31, 2014 ... Miami facilities to meet the ... Latin America .  The newly expanded facility will ... biological samples, consolidation of shipments to and from the ... In its newest location, Marken will combine its ...
(Date:7/31/2014)... , July 31, 2014  Today,s Consumer Reports ... as an important reminder for consumers of the ... importance of initiatives such as the Acetaminophen Awareness ... consumer education campaign. Formed in 2010, the ... provider and consumer organizations dedicated to educating consumers ...
Breaking Medicine Technology:Columbia Laboratories' Subsidiary, Molecular Profiles, Strikes Alliance With Xenogesis 2Columbia Laboratories' Subsidiary, Molecular Profiles, Strikes Alliance With Xenogesis 3Marken Expands Miami Regional Logistics Center 2U.S. Health Coalition Calls for Continued Education on Acetaminophen, America's Most Common Drug Ingredient 2
Cached News: