HOME >> MEDICINE >> NEWS
UI findings indicate DNA methylation process may lead to oral cancer

IOWA CITY, Iowa--Just like a light switch, a process known as cytosine methylation can turn off expression of tumor suppressor genes and lead to oral cancer, according to University of Iowa Health Care research findings.

"During cancer development, the normal control of cytosine methylation is lost, and DNA can become aberrantly methylated," explained Frederick Domann, Ph.D., UI associate professor of radiology. "When this happens to a tumor suppressor gene, it switches off its expression and contributes to cancer progression."

For some time now, cancer researchers have focused on tumor suppressor genes in an attempt to answer the question of how cancer grows and spreads. When they work properly, tumor suppressor genes do just what their name suggests: They suppress cancer. However, if something disrupts the genes, the cancer grows and stretches into other areas of the body.

Classical genetics has shown that mutations and deletions of these tumor suppressor genes contribute to malignancy. However, another mechanism, DNA methylation, can inactivate tumor gene expression as well, Domann said. This methylation phenomenon is the focus of Domann's lab investigations. Methylation is the addition of single carbon atoms to specific target sites within the DNA.

Cytosine, one of the four nucleotides in DNA, is the only base that can be methylated normally by a cell's enzymatic machinery. Cytosine is normally methylated in cells at certain positions and not others. Carcinogenesis alters the pattern of cytosine methylation, which contributes to altered patterns of gene expression in cancer.

Based on the interest of one of his then post-doctoral fellows, D. Thane Cody II, M.D., currently assistant professor of surgery at Southern Illinois University, Domann and his team began investigating whether aberrant methylation contributed to oral cancer tumors. There were more than 28,000 news cases of oral cancer in the United States in 1995, resulting in more
'"/>

Contact: Jennifer Cronin
jennifer-cronin@uiowa.edu
319-335-9917
University of Iowa
4-Oct-1999


Page: 1 2 3

Related medicine news :

1. Statement on the findings of the Womens Health Study
2. Latest findings on genetic blood disorder Cooleys Anemia
3. Hard choices: Pitt researcher presents findings on when to accept organ transplants
4. Contrary to previous findings, smoking is detrimental to patients with Alzheimers
5. Medical meeting to feature research findings and disease prevention and health promotion sessions
6. New findings on patient safety at childrens hospitals
7. Nerve navigation findings prompt new direction for spinal cord research
8. Testosterone may help in recovery from strokes, suggests preliminary findings in study
9. Study findings question claims of significant savings from pharmacy dose consolidation programs
10. Some positive findings in new study on cocaine exposed children
11. Novel findings about neovessel formation

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: findings indicate DNA methylation process may lead oral cancer

(Date:9/1/2015)... Toronto, ON (PRWEB) , ... September 01, 2015 ... ... Trade Secrets, a leading retailer of professional hair salons. This highly anticipated partnership ... all of the Curl Keeper™ Styling Collection. Founder Jonathan Torch and the Curly ...
(Date:8/31/2015)... ... , ... The PT Outcomes Registry is an organized system for collecting data ... Registry is being developed by the American Physical Therapy Association (APTA). , Al Amato, ... to contribute FOTO Outcomes measures as one of the primary global outcomes measures to ...
(Date:8/31/2015)... ... August 31, 2015 , ... ... industry, released their latest predictive use case focused on helping hospital perform under ... Under this program, hospital payments are adjusted based on performance across four domains ...
(Date:8/31/2015)... ... 2015 , ... Cosmetic Town Journal is an online plastic ... a successful cosmetic procedure; from publishing encyclopedic medical articles to inform patients and ... to help. , It is clear that the Cosmetic Town aesthetic surgery community ...
(Date:8/31/2015)... ... 2015 , ... Dental clinicians from Newcastle University, United Kingdom, ... learn more about its integrated approach to diabetes care. , Philip Preshaw, BDS, ... Medicine at Newcastle University, and Susan Bissett, National Institute for Health Research Clinical ...
Breaking Medicine News(10 mins):Health News:Curly Hair Solutions™ Partners With Trade Secrets 2Health News:FOTO Selected as Official Registry Partner with Physical Therapy Outcomes Registry 2Health News:Jvion Releases Value-Based Purchasing Predictive Use Case 2Health News:Cosmetic Town: A One Stop Plastic Surgery Community 2Health News:Western Diabetes Institute Collaborates with UK team 2Health News:Western Diabetes Institute Collaborates with UK team 3Health News:Western Diabetes Institute Collaborates with UK team 4
(Date:8/31/2015)... Regen BioPharma, Inc. (OTCBB: RGBP) and ... means of delivering its patented (US Patent 8,263,571) ... utilizing a clinically approved formulation as delivery system.  ... gene silencing therapeutics in which the gene silencing ... body.  By utilizing a local delivery system, potential ...
(Date:8/31/2015)... and MOUNTAIN VIEW, Calif. , ... SNY ; EURONEXT: SAN) and the life sciences team ... improve care and outcomes for people with type 1 ... diabetes treatments and devices with Google,s expertise in analytics, ... will explore how to improve diabetes care by developing ...
(Date:8/31/2015)... 31, 2015  Qualcomm Incorporated (NASDAQ: QCOM ... Life, Inc., is collaborating with Davita Healthcare ... solutions powered by Qualcomm Life,s 2net™ Device Connectivity ... continuous care, informed interventions and better management of ... Life,s annual Connect 2015 ecosystem conference ...
Breaking Medicine Technology:Regen BioPharma, Inc. Develops BORIS Gene Silencing Based Treatment for Unresectable Liver Cancer 2Regen BioPharma, Inc. Develops BORIS Gene Silencing Based Treatment for Unresectable Liver Cancer 3Sanofi to Collaborate with Google Life Sciences to Improve Diabetes Health Outcomes 2Sanofi to Collaborate with Google Life Sciences to Improve Diabetes Health Outcomes 3Sanofi to Collaborate with Google Life Sciences to Improve Diabetes Health Outcomes 4Sanofi to Collaborate with Google Life Sciences to Improve Diabetes Health Outcomes 5Sanofi to Collaborate with Google Life Sciences to Improve Diabetes Health Outcomes 6Qualcomm Life Announces New Connected Health Collaborations at Connect 2015 2Qualcomm Life Announces New Connected Health Collaborations at Connect 2015 3Qualcomm Life Announces New Connected Health Collaborations at Connect 2015 4Qualcomm Life Announces New Connected Health Collaborations at Connect 2015 5
Cached News: