HOME >> MEDICINE >> NEWS
UI findings indicate DNA methylation process may lead to oral cancer

IOWA CITY, Iowa--Just like a light switch, a process known as cytosine methylation can turn off expression of tumor suppressor genes and lead to oral cancer, according to University of Iowa Health Care research findings.

"During cancer development, the normal control of cytosine methylation is lost, and DNA can become aberrantly methylated," explained Frederick Domann, Ph.D., UI associate professor of radiology. "When this happens to a tumor suppressor gene, it switches off its expression and contributes to cancer progression."

For some time now, cancer researchers have focused on tumor suppressor genes in an attempt to answer the question of how cancer grows and spreads. When they work properly, tumor suppressor genes do just what their name suggests: They suppress cancer. However, if something disrupts the genes, the cancer grows and stretches into other areas of the body.

Classical genetics has shown that mutations and deletions of these tumor suppressor genes contribute to malignancy. However, another mechanism, DNA methylation, can inactivate tumor gene expression as well, Domann said. This methylation phenomenon is the focus of Domann's lab investigations. Methylation is the addition of single carbon atoms to specific target sites within the DNA.

Cytosine, one of the four nucleotides in DNA, is the only base that can be methylated normally by a cell's enzymatic machinery. Cytosine is normally methylated in cells at certain positions and not others. Carcinogenesis alters the pattern of cytosine methylation, which contributes to altered patterns of gene expression in cancer.

Based on the interest of one of his then post-doctoral fellows, D. Thane Cody II, M.D., currently assistant professor of surgery at Southern Illinois University, Domann and his team began investigating whether aberrant methylation contributed to oral cancer tumors. There were more than 28,000 news cases of oral cancer in the United States in 1995, resulting in more
'"/>

Contact: Jennifer Cronin
jennifer-cronin@uiowa.edu
319-335-9917
University of Iowa
4-Oct-1999


Page: 1 2 3

Related medicine news :

1. Statement on the findings of the Womens Health Study
2. Latest findings on genetic blood disorder Cooleys Anemia
3. Hard choices: Pitt researcher presents findings on when to accept organ transplants
4. Contrary to previous findings, smoking is detrimental to patients with Alzheimers
5. Medical meeting to feature research findings and disease prevention and health promotion sessions
6. New findings on patient safety at childrens hospitals
7. Nerve navigation findings prompt new direction for spinal cord research
8. Testosterone may help in recovery from strokes, suggests preliminary findings in study
9. Study findings question claims of significant savings from pharmacy dose consolidation programs
10. Some positive findings in new study on cocaine exposed children
11. Novel findings about neovessel formation

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: findings indicate DNA methylation process may lead oral cancer

(Date:1/22/2015)... The City of West Hollywood hosted a news conference on Thursday, ... of the Supreme Court decision Roe v. Wade, which legalized abortion ... Roe vs. Wade decision and the fight to protect a women’s ... of West Hollywood Councilmember Abbe Land. “We need to continue to ...
(Date:1/22/2015)... VogueQueen is a seasoned and trusted leader who consistently ... thrilled to have it lead the wedding dress industry into ... prom dresses for the global market. , “The CEO of ... he focuses on continuing the goal of operational excellence and ...
(Date:1/22/2015)... (PRWEB) January 23, 2015 AngelWeddingDress, the ... of 2015 maternity wedding dresses. View website ... are looking for maternity wedding dresses online for a ... gowns with high quality for them. Its maternity wedding ...
(Date:1/22/2015)... Thousand of GranuFlo lawsuits ( http://www.granuflolawsuit2014.com/ ... GranuFlo and NaturaLyte dialysis concentrates continue to move forward ... Court, District of Massachusetts, Bernstein Liebhard LLP reports. According ... remanded a case filed by the state of Louisiana ...
(Date:1/22/2015)... January 22, 2015 Joan Lunden, award-winning ... speaker at the upcoming 32nd Annual Miami Breast ... Physicians’ Education Resource®, LLC (PER®) , shares that “a ... gone undetected if she had not followed up her ...
Breaking Medicine News(10 mins):Health News:VogueQueen Unveils New Designs of Prom Dresses for 2015 2Health News:AngelWeddingDress Has Recently Released Its Collection Of 2015 Maternity Wedding Dresses 2Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 2Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 3Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 4Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 2Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 3Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 4Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 5Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 6
(Date:1/23/2015)... 2015 Gem Pharmaceuticals announced today that the initial ... the Company,s Phase 2 clinical trial.  This open-label study ... compound, GPX-150 (an investigational medication), in approximately 30 adults ... Logo - http://photos.prnewswire.com/prnh/20150123/170966LOGO ...
(Date:1/23/2015)... , Jan. 23, 2015 Tianyin Pharmaceutical Inc. ... that specializes in the development and sale of patented ... and active pharmaceutical ingredients (API) today announced the business ... API operation. 1. Following the September 2014 ...
(Date:1/22/2015)... 2015  BiOptix is pleased to announce the appointment of ... Chemistry and Biochemistry. Scott joins the company after previous scientific ... throughout the course of his nearly 20 year career ... a nationally recognized thought leader in the biosensor field ...
Breaking Medicine Technology:Gem Pharmaceuticals Announces Enrollment of Initial Patients in its Phase 2 Clinical Trial to Assess the Efficacy and Safety of GPX-150 in Sarcoma Patients 2TPI's JCM Updates on Import Registration for International Clients 2TPI's JCM Updates on Import Registration for International Clients 3TPI's JCM Updates on Import Registration for International Clients 4BiOptix Expands Leadership Team with the Appointment of Dr. Scott Klakamp as Vice President of Chemistry and Biochemistry 2
Cached News: