HOME >> MEDICINE >> NEWS
UI findings indicate DNA methylation process may lead to oral cancer

than 8,000 deaths.

Cody had identified an oral cancer cell line that had lost expression of the tumor suppressor gene p16INK4A gene but in which the gene was still intact. Because the gene was still intact, the investigators knew that the cell line had not suffered any gross tumor suppressor gene deletion and that methylation might be to blame for the cancer.

To test their hypothesis, the researchers isolated DNA from normal human oral keratinocytes and from the cancer cell line.

"We found a really striking difference in the methylation patterns of cytosine," Domann said. "In the normal human oral keratinocytes that had p16 expression, we found there was virutally no cytosine methylation, and the cancer cells that lacked p16 expression were nearly completely methylated."

Domann and his research team plan to do additional methylation studies to screen other oral cancer cell lines.

"We think that this might be a general mechanism in oral cancers, as well as in other cancers, for inactivating this gene locus," Domann said.

P16INK4A is a broad-acting tumor suppressor gene. Its methylation, and its deletion and mutation can be found in various tumor types, Domann said.

Although Domann stressed that the clinically relevancy of his lab's findings is still years away, aberrant cytosine methylation eventually can be corrected. Ezymes in the cell, called DNA methyltransferase, mediate methylation.

"Any process that is mediated by an enzyme has the potential to be pharmacologically affected," Domann said. "Those enzymes can be targeted by drugs that are designed to inhibit the active sites for those enzymes."

The findings of Domann's research team appeared in a recent issue of the peer-reviewed European Journal of Cancer, Oral Oncology. Funding from the National Institutes of Health helped support this research.

In addition to Domann and Cody, the other researchers involved included Yuanhui Huang, Ph.D., currently a postdoctoral resear
'"/>

Contact: Jennifer Cronin
jennifer-cronin@uiowa.edu
319-335-9917
University of Iowa
4-Oct-1999


Page: 1 2 3

Related medicine news :

1. Statement on the findings of the Womens Health Study
2. Latest findings on genetic blood disorder Cooleys Anemia
3. Hard choices: Pitt researcher presents findings on when to accept organ transplants
4. Contrary to previous findings, smoking is detrimental to patients with Alzheimers
5. Medical meeting to feature research findings and disease prevention and health promotion sessions
6. New findings on patient safety at childrens hospitals
7. Nerve navigation findings prompt new direction for spinal cord research
8. Testosterone may help in recovery from strokes, suggests preliminary findings in study
9. Study findings question claims of significant savings from pharmacy dose consolidation programs
10. Some positive findings in new study on cocaine exposed children
11. Novel findings about neovessel formation

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/23/2019)... ... August 22, 2019 , ... Williamson Memorial Hospital (WMH) will officially ... care organization but especially for community hospitals like WMH, which statistics show are closing ... in the community, it’s also taking steps to ensure it’s equipped to serve the ...
(Date:8/21/2019)... NEW YORK (PRWEB) , ... August 21, 2019 ... ... what do you need to know? , A video accompanying this announcement is ... the wellness world by storm. CBD products can be found on the ...
(Date:8/21/2019)... ... 21, 2019 , ... Photoprotective Technologies (PPT) has just received US patent 10/357,124 ... used in skincare products such as creams or makeup and is distributed by Vantage ... to protect the skin from blue light as well as UV. , Melanin ...
(Date:8/19/2019)... ... August 19, 2019 , ... ... Eminence Organic Skin Care products , the authorized retailer will change its corporate ... a practicing esthetician in Florida providing Eminence Organic Skin Care facials and treatments. ...
(Date:8/19/2019)... ... August 19, 2019 , ... Cosmetic Town, an online plastic surgery ... hair restoration doctors in New York currently providing a lifetime of natural looking results ... see some thinning hair. Cosmetic Town makes the process of finding information about these ...
Breaking Medicine News(10 mins):
(Date:8/19/2019)... ... August 19, 2019 , ... The International Association ... of excellence within the field of treatment for eating disorders, recommends membership for ... others who have a similar mission. , Founded in 1985, the iaedp™ ...
(Date:8/17/2019)... (PRWEB) , ... August 17, 2019 , ... ... Companies—the Inc. 5000 , Foster Crown, LLC Ranks No. 2502 on the 2019 ... revealed that Foster Crown, LLC, the boutique physician recruitment firm is No. 2502 ...
(Date:8/16/2019)... ... August 16, 2019 , ... Healthpointe is ... and Reprocessing therapy (EMDR). This therapeutic technique aims to reduce psychological distress, promote ... post-traumatic stress disorder (PTSD), depression, chronic pain, anxiety, and grief. EMDR is ...
Breaking Medicine Technology:
Cached News: