HOME >> MEDICINE >> NEWS
UI-led study shows experimental anti-cancer drug also has anti-HIV properties

The results of a study led by a University of Iowa researcher suggest that a drug already undergoing stage I and II clinical trials as a cancer treatment may also have potential as an anti-HIV therapy.

The study, led by David Price, Ph.D., a UI professor of biochemistry working with Matija Peterlin at the University of California San Francisco and Adrian Senderowicz at the National Cancer Institute, found that very low concentrations of flavopiridol, a drug manufactured by Aventis Inc., blocks HIV-1 replication in cell culture experiments. These findings appeared in the July 21 online issue of the Journal of Biological Chemistry.

Flavopiridol strongly hinders the cellular process known as transcription, a multi-step process which results in the production of ribonucleic acid (RNA). Cells use the genetic information encoded by these long RNA molecules to make proteins.

Flavopiridol effectively blocks the action of an enzyme called P-TEFb, which controls one of the steps in the transcription process. In fact, flavopiridol is the most powerful P-TEFb inhibitor to date. In Price's test tube experiments, even extremely low concentrations of flavopiridol were effective at blocking the action of P-TEFb.

P-TEFb is required for transcription of the HIV-1 genome to occur. Flavopiridol inhibits P-TEFb, causing inhibition of transcription. In tests to investigate its effect on HIV-1 infection and viral spread in cultured human cells, Price's team found that the same low concentrations of flavopiridol that inhibited P-TEFb dramatically blocked HIV-1 infection and replication.

"Since P-TEFb is a key factor in HIV-1 infection and flavopiridol blocks HIV-1 propagation in culture, we believe that this substance should be tested as a potential anti-AIDS drug," Price said.

During infection, HIV-1 undergoes mutations in its DNA that allow its proteins to change and become resistant to drugs. This is one of the biggest problems with treatment of HIV. Many
'"/>

Contact: Jennifer Brown
brownj@mail.medicine.uiowa.edu
319-335-9917
University of Iowa
2-Aug-2000


Page: 1 2

Related medicine news :

1. UI-led study indicates surgery is the best treatment for severe Bells palsy paralysis
2. First head-to-head study to compare lidoderm patch and Celebrex in treating pain
3. UMaine study looks at infants and chronic nighttime crying
4. Chronic pain treatments more effective when taken together, new study shows
5. UNC study: Most N.C. family practitioners engage in unrecognized community service
6. New study in Nature demonstrates protection against cell death during heart attack
7. UCSF study offers insight into human circadian rhythms
8. International breast cancer prevention study launches in the United States and Canada
9. UW study shows blacks and Latinos are more satisfied with physicians of the same race
10. Physicians may not be accurate in their confidence levels of their diagnoses, says Pitt study
11. Advertising by academic medical centers may risk eroding public trust, says study

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/5/2020)... , ... April 04, 2020 , ... ... report conforming to the newly mandated federal reporting of COVID-19 testing that must ... March 29, 2020, Vice President Pence announced that all hospitals report data on ...
(Date:4/2/2020)... (PRWEB) , ... April 02, 2020 , ... LifeLearn ... VetFolio , today announced the launch of the veterinary CE course COVID-19: What ... indefinitely for VetFolio subscribers. , “When it comes to COVID-19, it’s important for practices ...
(Date:4/1/2020)... ... April 02, 2020 , ... AAGL Gynecologic Surgeons host ... to discuss surgical safety practices in response to the COVID-19 crisis. , ... Network in New Orleans and Amsterdam University Medical Center in the Netherlands will ...
(Date:4/1/2020)... FREDERICK, Md. (PRWEB) , ... April 01, 2020 , ... ... new method using its revolutionary NEXTGENPCR that decreases the testing time for ... this method, a single unit the size of a shoebox could perform a hundred ...
(Date:3/30/2020)... , ... March 30, 2020 , ... ... the coronavirus pandemic sweeps the country. In an effort to keep frontline officers ... are enabling police interaction with community members while minimizing direct contact. They are ...
Breaking Medicine News(10 mins):
(Date:4/2/2020)... ... , ... NCPDP has elected its 2020-2021 Board of Trustees. The new Board ... on Wednesday, May 6, 2020. , Election Results – Newly Elected Board Members:, ... elected to the Board of Trustees. , Morgan Bojorquez, Director, Pharmacy Clinical ...
(Date:4/2/2020)... ... , ... Caitlin Richardson, a University of Washington MEDEX Physician ... Scholarship. , The $1,000 scholarship, awarded biannually to U.S. students who show ... the students pay tuition and other college-related expenses. , Rhonda Abbe, Director of ...
(Date:4/1/2020)... ... April 01, 2020 , ... Care Station Medical Group -- In ... a number of changes to better care for our community. As New Jersey's leading ... and crafted new ways to offer medical care to patients coping with COVID-19. ...
Breaking Medicine Technology:
Cached News: