HOME >> MEDICINE >> NEWS
UI-led study shows experimental anti-cancer drug also has anti-HIV properties

The results of a study led by a University of Iowa researcher suggest that a drug already undergoing stage I and II clinical trials as a cancer treatment may also have potential as an anti-HIV therapy.

The study, led by David Price, Ph.D., a UI professor of biochemistry working with Matija Peterlin at the University of California San Francisco and Adrian Senderowicz at the National Cancer Institute, found that very low concentrations of flavopiridol, a drug manufactured by Aventis Inc., blocks HIV-1 replication in cell culture experiments. These findings appeared in the July 21 online issue of the Journal of Biological Chemistry.

Flavopiridol strongly hinders the cellular process known as transcription, a multi-step process which results in the production of ribonucleic acid (RNA). Cells use the genetic information encoded by these long RNA molecules to make proteins.

Flavopiridol effectively blocks the action of an enzyme called P-TEFb, which controls one of the steps in the transcription process. In fact, flavopiridol is the most powerful P-TEFb inhibitor to date. In Price's test tube experiments, even extremely low concentrations of flavopiridol were effective at blocking the action of P-TEFb.

P-TEFb is required for transcription of the HIV-1 genome to occur. Flavopiridol inhibits P-TEFb, causing inhibition of transcription. In tests to investigate its effect on HIV-1 infection and viral spread in cultured human cells, Price's team found that the same low concentrations of flavopiridol that inhibited P-TEFb dramatically blocked HIV-1 infection and replication.

"Since P-TEFb is a key factor in HIV-1 infection and flavopiridol blocks HIV-1 propagation in culture, we believe that this substance should be tested as a potential anti-AIDS drug," Price said.

During infection, HIV-1 undergoes mutations in its DNA that allow its proteins to change and become resistant to drugs. This is one of the biggest problems with treatment of HIV. Many
'"/>

Contact: Jennifer Brown
brownj@mail.medicine.uiowa.edu
319-335-9917
University of Iowa
2-Aug-2000


Page: 1 2

Related medicine news :

1. UI-led study indicates surgery is the best treatment for severe Bells palsy paralysis
2. First head-to-head study to compare lidoderm patch and Celebrex in treating pain
3. UMaine study looks at infants and chronic nighttime crying
4. Chronic pain treatments more effective when taken together, new study shows
5. UNC study: Most N.C. family practitioners engage in unrecognized community service
6. New study in Nature demonstrates protection against cell death during heart attack
7. UCSF study offers insight into human circadian rhythms
8. International breast cancer prevention study launches in the United States and Canada
9. UW study shows blacks and Latinos are more satisfied with physicians of the same race
10. Physicians may not be accurate in their confidence levels of their diagnoses, says Pitt study
11. Advertising by academic medical centers may risk eroding public trust, says study

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/13/2018)... ... December 13, 2018 , ... ... more modern and approachable in their community. Delia Associates created a solid and ... for those dealing with substance abuse in the greater Hunterdon County area. The ...
(Date:12/13/2018)... ... 13, 2018 , ... FOR IMMEDIATE RELEASE , Fellow Health ... to providing more jobs in America, Fellow Health Partners introduces Knowledge College™ Careers ... based medical business solutions company, today announced the launch of Knowledge College Careers, ...
(Date:12/13/2018)... ... 13, 2018 , ... The American College of Lifestyle Medicine ... grand rounds, medical schools, medical conferences and other events for health professionals. This ... Lifestyle Medicine—using lifestyle prescriptions as a therapeutic intervention to treat, often reverse and ...
(Date:12/10/2018)... ... ... Loma Linda University School of Public Health researchers released the ... with freight-railyard pollution to asthma-related emergency room visits in children. The study was recently ... is a follow-up to the i nitial study of a railyard located ...
(Date:12/8/2018)... ... December 07, 2018 , ... Dr. Masi Reynolds is a ... area with a valued expertise in minimally-invasive orthopedic care. Dr. Reynolds brings a ... on the latest and least-invasive treatment options available in orthopedics. To this end, ...
Breaking Medicine News(10 mins):
(Date:12/6/2018)... Fla. (PRWEB) , ... December 06, 2018 , ... Daylight ... Up for Kids Palm Beach”. The nonprofit serves 1500 children countywide who are in ... but is also fighting against the stigma that surrounds local treatment centers. , “With ...
(Date:12/5/2018)... LAUDERDALE, Fla. (PRWEB) , ... December 05, 2018 ... ... care navigation and revenue cycle management announced the hiring of Dr. Tony Andrulonis, ... helm a rapidly growing workforce of over 20,000 medical scribes and support staff. ...
(Date:12/5/2018)... ... 05, 2018 , ... Join the BFE in celebrating its ... biofeedback conference to nurture communication and education between specialists from different disciplines. Experts ... to share and learn. The meeting offers a broad range of basic and ...
Breaking Medicine Technology:
Cached News: