HOME >> MEDICINE >> NEWS
UI researchers find more natural method to possibly induce vascular growth

IOWA CITY, Iowa--By lowering an individual's heart rate, doctors someday may be able to trigger the sprouting of new blood vessels without having to resort to invasive methods, according to results from a University of Iowa Health Care study.

In recent years, a substance known as vascular endothelial growth factor (VEGF) has attracted the attention of researchers who are looking for ways to develop new blood vessels to replaces those either damaged or blocked from coronary conditions.

Until now, the focus has been on using either injections of the needed VEGF or using the gene therapy strategy, which involves delivering the VEGF to its intended destination via a disabled cold virus carrier. Robert J. Tomanek, Ph.D., UI professor anatomy and cell biology, and his research team are looking at a less intrusive, more natural approach.

"Gene therapy is one avenue to bring about vascular growth, but if you can use either pharmacological interventions or some interventions that change the physiology of the heart so that the heart does it naturally, then I think that is better because it is noninvasive," Tomanek said.

Wei Zheng, Ph.D., a postdoctoral fellow in Tomanek's lab, was able to get laboratory rats to produce the needed VEGF by using a heart rate lowering drug. A lowered rate allows the heart to fill with more blood at each beat. The increased blood causes the heart to stretch, which Tomanek believes induces the animal to produce VEGF.

VEGF then triggers endothelial cells, the building blocks of the blood vessels, to proliferate.

"VEGF causes the endothelial cells to migrate, line up and actually form the vascular structures," Tomanek explained.

Tomanek and his colleagues are continuing to study VEGF and other growth factors, attempting to learn more about the mechanisms involved with coronary vascular growth.

"Hopefully, this can get to the stage where it can be applied to humans," Tomanek said.

A grant from the National In
'"/>

Contact: Jennifer Cronin
jennifer-cronin@uiowa.edu
319-335-9917
University of Iowa
22-Sep-1999


Page: 1 2

Related medicine news :

1. Indiana University researchers closer to helping hearing-impaired using stem cells
2. Protein that helps skin cancer spread identified by Stanford researchers
3. US life expectancy about to decline, researchers say
4. Gene for age-related macular degeneration discovered by Yale researchers
5. Dartmouth researchers find where musical memories are stored in the brain
6. Columbia researchers receive $3 million to combat genetic killer of infants & toddlers
7. US cancer researchers launch first American-Israeli cancer conference
8. USC dental researchers develop first test for predicting cavities in children
9. Young blood revives aging muscles, Stanford researchers find
10. Uric acid may help reduce effects of spinal cord injury, Jefferson researchers find
11. Age should not be a factor in determining heart transplantation eligibility, researchers say

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/9/2019)... ... July 09, 2019 , ... Leading healthcare ... Association of American Cancer Institutes – Clinical Research Innovation (AACI-CRI) annual meeting, held ... management and data analysis. As the leading provider of clinical research technology solutions, ...
(Date:7/9/2019)... ... July 09, 2019 , ... ... in medical marketing and communications. Covering everything from multinational holding companies to five-person ... landscape. , The 2019 version of the Agency 100 contains a full profile ...
(Date:7/9/2019)... ... July 09, 2019 , ... ... tracking technology, today announced a validated integration between the Midmark real-time locating system ... enhancing Rauland’s nurse call platform with location data since 1997 and is implemented ...
(Date:7/9/2019)... Mass. (PRWEB) , ... July 09, 2019 , ... ... components worldwide and the largest authorized distributor for JAE Electronics in North America, ... interconnect products. , The new connectors feature a 0.5mm contact pitch and 2.5mm ...
(Date:7/9/2019)... ... ... Fonolo , the leader in cloud-based call-back solutions for the contact center, ... Prepare Your Call Center for Seasonal Call Spikes: Healthcare Edition . The new publication ... of year: Open enrollment. , Open enrollment is one of the busiest and most ...
Breaking Medicine News(10 mins):
(Date:7/10/2019)... ... 10, 2019 , ... Birk Manufacturing has announced that the company will be ... 2019, the largest exhibition for the global microelectronics industry in North America. The event ... 11, 2019. Birk Manufacturing will be showcasing at booth #152. , At the ...
(Date:7/9/2019)... ... July 10, 2019 , ... ... workshop presented by Cerulean Associates LLC and FDAnews**, Oct. 21-22, 2019, Doubletree by ... Early Bird Savings: Register by Sept. 23 and Save $200 , FDA gives ...
(Date:7/9/2019)... ... July 09, 2019 , ... DHL Global Forwarding, the air ... have released a joint report on the logistical challenges and opportunities posed by ... Partnerships: The Path to Personalized Medicine in Latin America”, the report provides a ...
Breaking Medicine Technology:
Cached News: