HOME >> MEDICINE >> NEWS
UI researchers find more natural method to possibly induce vascular growth

IOWA CITY, Iowa--By lowering an individual's heart rate, doctors someday may be able to trigger the sprouting of new blood vessels without having to resort to invasive methods, according to results from a University of Iowa Health Care study.

In recent years, a substance known as vascular endothelial growth factor (VEGF) has attracted the attention of researchers who are looking for ways to develop new blood vessels to replaces those either damaged or blocked from coronary conditions.

Until now, the focus has been on using either injections of the needed VEGF or using the gene therapy strategy, which involves delivering the VEGF to its intended destination via a disabled cold virus carrier. Robert J. Tomanek, Ph.D., UI professor anatomy and cell biology, and his research team are looking at a less intrusive, more natural approach.

"Gene therapy is one avenue to bring about vascular growth, but if you can use either pharmacological interventions or some interventions that change the physiology of the heart so that the heart does it naturally, then I think that is better because it is noninvasive," Tomanek said.

Wei Zheng, Ph.D., a postdoctoral fellow in Tomanek's lab, was able to get laboratory rats to produce the needed VEGF by using a heart rate lowering drug. A lowered rate allows the heart to fill with more blood at each beat. The increased blood causes the heart to stretch, which Tomanek believes induces the animal to produce VEGF.

VEGF then triggers endothelial cells, the building blocks of the blood vessels, to proliferate.

"VEGF causes the endothelial cells to migrate, line up and actually form the vascular structures," Tomanek explained.

Tomanek and his colleagues are continuing to study VEGF and other growth factors, attempting to learn more about the mechanisms involved with coronary vascular growth.

"Hopefully, this can get to the stage where it can be applied to humans," Tomanek said.

A grant from the National In
'"/>

Contact: Jennifer Cronin
jennifer-cronin@uiowa.edu
319-335-9917
University of Iowa
22-Sep-1999


Page: 1 2

Related medicine news :

1. Indiana University researchers closer to helping hearing-impaired using stem cells
2. Protein that helps skin cancer spread identified by Stanford researchers
3. US life expectancy about to decline, researchers say
4. Gene for age-related macular degeneration discovered by Yale researchers
5. Dartmouth researchers find where musical memories are stored in the brain
6. Columbia researchers receive $3 million to combat genetic killer of infants & toddlers
7. US cancer researchers launch first American-Israeli cancer conference
8. USC dental researchers develop first test for predicting cavities in children
9. Young blood revives aging muscles, Stanford researchers find
10. Uric acid may help reduce effects of spinal cord injury, Jefferson researchers find
11. Age should not be a factor in determining heart transplantation eligibility, researchers say

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/8/2019)... AVON, Conn. (PRWEB) , ... October 08, 2019 ... ... fertility centers, recently acquired a majority interest in Advanced Fertility Care (AFC), an ... entities are joining forces to expand the availability of RE services to expectant ...
(Date:10/8/2019)... Md. (PRWEB) , ... October 08, 2019 , ... ... fungal infection progression in live samples, Meiqing Shi, associate professor with the University ... field. In his latest paper published in Nature Communications, Shi and his lab ...
(Date:10/8/2019)... ... , ... METAvivor Research and Support Inc., a non-profit organization dedicated to funding ... Stampede campaign. The campaign will commence with two days of action and education on ... camp, a march, a Die-In (hosted by partner MET-UP), and visits with Congressional offices. ...
(Date:10/8/2019)... ... October 08, 2019 , ... Dr. ... has recently attended an advanced Level III training in Cagliari, Italy, this past ... training took place September 16-19, 2019 at the Sardinia Dental Teaching Center and ...
(Date:10/8/2019)... (PRWEB) , ... October 08, 2019 , ... ... company headquartered in Irving, Texas, that exclusively serves premier oral and maxillofacial surgeons ... an oral and maxillofacial surgery practice with two locations near Knoxville, Tennessee. The ...
Breaking Medicine News(10 mins):
(Date:10/10/2019)... ... October 10, 2019 , ... Hospice ... on Thursday, September 26, at the Westchester Country Club in Rye. The event ... of the organization and its mission. , “In Celebration” featured live entertainment, culinary ...
(Date:10/9/2019)... ... October 09, 2019 , ... Drs. Steven White, Brad Haines and Colton Fischer ... sleep apnea in Davidson, NC. If left untreated, sleep apnea can cause mental ... of a skilled dentist, those who suffer from snoring at night and excessive fatigue ...
(Date:10/8/2019)... (PRWEB) , ... October 08, 2019 , ... ... of Charleston. Dr. Robert Carimi and his caring team are thrilled to create ... from dental anxiety in Charleston, SC. The mission of Sedation Dentistry ...
Breaking Medicine Technology:
Cached News: