HOME >> MEDICINE >> NEWS
UI study identifies mechanism that causes cardiomyopathy, exacerbates muscular dystrophy

of sarcoglycan, identified as the delta subunit, experienced severe muscular dystrophy with large areas of cardiac cell death. Campbell and other researchers in his lab determined that this disruption in the sarcoglycan complex upsets vascular function and causes injury in cardiac and skeletal muscles. This injury leads to cardiac complications, which exacerbate LGMD.

"A number of proteins in cardiac muscle have been shown to be involved in cardiomyopathy," Campbell said. "However, our study opens up a unique and important new avenue of research directed toward the involvement of the vascular smooth muscle sarcoglycan-sarcospan complex in the cause and progression of cardiomyopathy."

Now that Campbell's lab has identified the problem that leads to cardiomyopathy in patients with LGMD, the next step is to look at possible pharmacological treatments to prevent vascular smooth muscle dysfunction. Campbell also wants to investigate gene transfer as a way to repair the sarcoglycan complex in vascular smooth muscles and develop additional animal models to evaluate smooth muscle contributions to cardiomyopathy.

In addition to Campbell, the other two primary investigators of this most recent study included postdoctoral associates Ramon Coral-Vazquez, Ph.D., and Ronald D. Cohn, M.D., both members of Campbell's Howard Hughes Medical Institute lab team. Other UI collaborators included Joseph A. Hill, M.D., Ph.D., assistant professor of internal medicine; Robert M. Weiss, M.D., associate professor of internal medicine; Robin Davisson, Ph.D., assistant professor of anatomy and cell biology; Steve Moore, M.D., Ph.D., professor of pathology; and Roger Williamson, M.D., professor of obstetrics and gynecology.

In addition to support from the Howard Hughes Medical Institute, the Muscular Dystrophy Association also funded this research.


'"/>

Contact: Jennifer Cronin
jennifer-cronin@uiowa.edu
319-335-9917
University of Iowa
17-Aug-1999


Page: 1 2

Related medicine news :

1. First head-to-head study to compare lidoderm patch and Celebrex in treating pain
2. UMaine study looks at infants and chronic nighttime crying
3. Chronic pain treatments more effective when taken together, new study shows
4. UNC study: Most N.C. family practitioners engage in unrecognized community service
5. New study in Nature demonstrates protection against cell death during heart attack
6. UCSF study offers insight into human circadian rhythms
7. International breast cancer prevention study launches in the United States and Canada
8. UW study shows blacks and Latinos are more satisfied with physicians of the same race
9. Physicians may not be accurate in their confidence levels of their diagnoses, says Pitt study
10. Advertising by academic medical centers may risk eroding public trust, says study
11. Fat may promote inflammation, new study suggests

Post Your Comments:
(Date:7/31/2014)... Los Angeles, CA (PRWEB) July 31, 2014 ... donor wound closure in front of an enthusiastic audience ... Partial Trichophytic Closure improves the appearance of ... since the results of this procedure are minimally detectable ... this novel technique improves on the original method of ...
(Date:7/31/2014)... Washington, New York (PRWEB) July 31, 2014 ... represents whistleblowers in qui tam cases, comments that whistleblowers ... an end to illegal employer activities that may cause ... recognizes that today is National Whistleblower Appreciation Day. , ... National Whistleblower Center , the Senate declared "National Whistleblower ...
(Date:7/31/2014)... 2014 Located on one of the busiest ... Rothenberg Law Firm LLP has moved its office to the ... Rothenberg Law Firm has been handling catastrophic personal injury cases ... growth in the firm’s continued success in seeking justice for ... office has a team of experienced and successful trial attorneys ...
(Date:7/31/2014)... July 31, 2014 CarePoint Health ... Dr. Masood Rizvi, has joined our network, CarePoint ... to the community. Hundreds of highly skilled and ... comprehensive network of top doctors and practices in ... This latest acquisition represents CarePoint Health’s commitment to ...
(Date:7/31/2014)... To further educate the public, The Rothenberg Law ... information regarding leaving children in hot vehicles: , Leaving ... Because a child’s body can heat up three to ... alone in a hot vehicle puts them at extreme ... of Children Left Alone in a Car , According ...
Breaking Medicine News(10 mins):Health News:Novel Technique in Wound Closure Delivers More Discreet Results in Hair Transplant Patients 2Health News:National Whistleblower Appreciation Day Declared to Ensure Recognition of Enormous Contribution to the Democracy by Whistleblowers, Parker Waichman LLP Comments 2Health News:National Whistleblower Appreciation Day Declared to Ensure Recognition of Enormous Contribution to the Democracy by Whistleblowers, Parker Waichman LLP Comments 3Health News:National Whistleblower Appreciation Day Declared to Ensure Recognition of Enormous Contribution to the Democracy by Whistleblowers, Parker Waichman LLP Comments 4Health News:Dr. Rizvi Joins CarePoint Health Medical Group 2Health News:The Rothenberg Law Firm LLP Teams Up with Local Philadelphia TV Stations to Promote Awareness of the Dangers of Leaving Children Unattended in a Hot Vehicle 2Health News:The Rothenberg Law Firm LLP Teams Up with Local Philadelphia TV Stations to Promote Awareness of the Dangers of Leaving Children Unattended in a Hot Vehicle 3
(Date:7/31/2014)... SAN DIEGO , July 31, 2014  Sorrento Therapeutics, ... death of Mr. Amar Singh , Chief Business Officer ... of apparent natural causes on July 30. "Sorrento ... dear friend and colleague. Our immediate thoughts go to Amar,s ... President and Chief Executive Officer. Mr. Singh ...
(Date:7/31/2014)... -- STAAR Surgical Company (NASDAQ: STAA ) ... and delivery systems for the eye today reported revenue ... $20.0 million, a 10% increase over $18.2 million reported ... currency basis, revenues grew 11% during the second quarter ... The effect of foreign currency exchange reduced sales by ...
(Date:7/31/2014)... VIEW, Calif., July 31, 2014 IRIDEX Corporation (Nasdaq: ... second quarter and six months ended June 28, 2014.  ... of 2014, up 15% from $9.2 million in the 2013 ... first quarter of 2014. Revenues for the first six months ... in the first six months of last year. , ...
Breaking Medicine Technology:Sorrento Announces the Unexpected Death of its Chief Business Officer 2STAAR Surgical Reports 10% Second Quarter Revenue Growth 2STAAR Surgical Reports 10% Second Quarter Revenue Growth 3STAAR Surgical Reports 10% Second Quarter Revenue Growth 4STAAR Surgical Reports 10% Second Quarter Revenue Growth 5STAAR Surgical Reports 10% Second Quarter Revenue Growth 6STAAR Surgical Reports 10% Second Quarter Revenue Growth 7STAAR Surgical Reports 10% Second Quarter Revenue Growth 8STAAR Surgical Reports 10% Second Quarter Revenue Growth 9STAAR Surgical Reports 10% Second Quarter Revenue Growth 10STAAR Surgical Reports 10% Second Quarter Revenue Growth 11STAAR Surgical Reports 10% Second Quarter Revenue Growth 12STAAR Surgical Reports 10% Second Quarter Revenue Growth 13STAAR Surgical Reports 10% Second Quarter Revenue Growth 14STAAR Surgical Reports 10% Second Quarter Revenue Growth 15STAAR Surgical Reports 10% Second Quarter Revenue Growth 16STAAR Surgical Reports 10% Second Quarter Revenue Growth 17STAAR Surgical Reports 10% Second Quarter Revenue Growth 18STAAR Surgical Reports 10% Second Quarter Revenue Growth 19STAAR Surgical Reports 10% Second Quarter Revenue Growth 20STAAR Surgical Reports 10% Second Quarter Revenue Growth 21STAAR Surgical Reports 10% Second Quarter Revenue Growth 22STAAR Surgical Reports 10% Second Quarter Revenue Growth 23STAAR Surgical Reports 10% Second Quarter Revenue Growth 24STAAR Surgical Reports 10% Second Quarter Revenue Growth 25STAAR Surgical Reports 10% Second Quarter Revenue Growth 26STAAR Surgical Reports 10% Second Quarter Revenue Growth 27STAAR Surgical Reports 10% Second Quarter Revenue Growth 28STAAR Surgical Reports 10% Second Quarter Revenue Growth 29STAAR Surgical Reports 10% Second Quarter Revenue Growth 30STAAR Surgical Reports 10% Second Quarter Revenue Growth 31IRIDEX Reports 2014 Second Quarter, Six-Month Results 2IRIDEX Reports 2014 Second Quarter, Six-Month Results 3IRIDEX Reports 2014 Second Quarter, Six-Month Results 4IRIDEX Reports 2014 Second Quarter, Six-Month Results 5
Cached News: