HOME >> MEDICINE >> NEWS
UI study identifies mechanism that causes cardiomyopathy, exacerbates muscular dystrophy

of sarcoglycan, identified as the delta subunit, experienced severe muscular dystrophy with large areas of cardiac cell death. Campbell and other researchers in his lab determined that this disruption in the sarcoglycan complex upsets vascular function and causes injury in cardiac and skeletal muscles. This injury leads to cardiac complications, which exacerbate LGMD.

"A number of proteins in cardiac muscle have been shown to be involved in cardiomyopathy," Campbell said. "However, our study opens up a unique and important new avenue of research directed toward the involvement of the vascular smooth muscle sarcoglycan-sarcospan complex in the cause and progression of cardiomyopathy."

Now that Campbell's lab has identified the problem that leads to cardiomyopathy in patients with LGMD, the next step is to look at possible pharmacological treatments to prevent vascular smooth muscle dysfunction. Campbell also wants to investigate gene transfer as a way to repair the sarcoglycan complex in vascular smooth muscles and develop additional animal models to evaluate smooth muscle contributions to cardiomyopathy.

In addition to Campbell, the other two primary investigators of this most recent study included postdoctoral associates Ramon Coral-Vazquez, Ph.D., and Ronald D. Cohn, M.D., both members of Campbell's Howard Hughes Medical Institute lab team. Other UI collaborators included Joseph A. Hill, M.D., Ph.D., assistant professor of internal medicine; Robert M. Weiss, M.D., associate professor of internal medicine; Robin Davisson, Ph.D., assistant professor of anatomy and cell biology; Steve Moore, M.D., Ph.D., professor of pathology; and Roger Williamson, M.D., professor of obstetrics and gynecology.

In addition to support from the Howard Hughes Medical Institute, the Muscular Dystrophy Association also funded this research.


'"/>

Contact: Jennifer Cronin
jennifer-cronin@uiowa.edu
319-335-9917
University of Iowa
17-Aug-1999


Page: 1 2

Related medicine news :

1. First head-to-head study to compare lidoderm patch and Celebrex in treating pain
2. UMaine study looks at infants and chronic nighttime crying
3. Chronic pain treatments more effective when taken together, new study shows
4. UNC study: Most N.C. family practitioners engage in unrecognized community service
5. New study in Nature demonstrates protection against cell death during heart attack
6. UCSF study offers insight into human circadian rhythms
7. International breast cancer prevention study launches in the United States and Canada
8. UW study shows blacks and Latinos are more satisfied with physicians of the same race
9. Physicians may not be accurate in their confidence levels of their diagnoses, says Pitt study
10. Advertising by academic medical centers may risk eroding public trust, says study
11. Fat may promote inflammation, new study suggests

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/10/2016)... ... December 10, 2016 , ... ... Santa are all sources of external stimuli that can put a great deal ... pressure to spread holiday cheer through gifts, food and festive gatherings can lead ...
(Date:12/10/2016)... Colorado (PRWEB) , ... December 10, 2016 , ... ... for the most vulnerable population in Syria’s civil war—babies and toddlers. , The ... run out. Families are experiencing bombing, facing starvation, and dying from disease. The ...
(Date:12/9/2016)... ... December 09, 2016 , ... ... offices in Pasco and Richland, is initiating a charity drive to support the ... from a recent automobile collision. , On October 29th of this year, ...
(Date:12/9/2016)... , ... December 09, 2016 , ... "I have gout, ... used this old family recipe, which is meant to relieve gout and pain caused ... me a 12-hour energy boost every time. It relieved what VA doctors called the ...
(Date:12/9/2016)... ... December 09, 2016 , ... An inventor from Cana, Va., wanted ... all types of amusement park rides. , The patent-pending SAFETY STRAP FOR AMPUTEES improves ... use and could be set up in a matter of minutes, or even seconds. ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... 8, 2016 Global Interventional Radiology Market: ... global interventional radiology market analyzes the current and ... an elaborate executive summary, including a market snapshot ... sub-segments. The research is a combination of ... bulk of our research efforts along with information ...
(Date:12/8/2016)... Lilly and Company (NYSE: LLY ) today ... at the 9 th Clinical Trials on Alzheimer,s ... meet the primary endpoint in the EXPEDITION3 clinical trial, ... dementia due to Alzheimer,s disease (AD), and Lilly will ... of mild dementia due to AD. ...
(Date:12/8/2016)... CITY , Dec. 8, 2016 ... US patents for improving the accuracy, reproducibility and ... images in long and small bone orthopaedic applications. ... approach to creating personalized orthopaedic restorations based on ... personalized orthopaedic restorations, the company harnesses the world,s ...
Breaking Medicine Technology:
Cached News: