UI study suggests variable effects of fetal alcohol syndrome on brain

IOWA CITY, Iowa -- Fetal alcohol syndrome in affected people has been associated with mental retardation and a smaller or nonexistent corpus callosum. The callosum is a major brain pathway that coordinates input from one side of the brain to the other to help provide unified sense perception. However, a study led by a University of Iowa Health Care researcher suggests that moderate (versus severe) alcohol overexposure can cause the corpus callosum to be larger than normal.

"Previous research showed that the corpus callosum is very small or even nonexistent in people with fetal alcohol syndrome," said Michael W. Miller, Ph.D., UI professor of psychiatry and pharmacology, and a career research scientist at the Iowa City Veterans Affairs Medical Center. "But this human data was quite at odds with other studies, including one at the UI involving rats, which showed maternal alcohol intake can increase the number of cells contributing connections passing through corpus callosum in offspring."

The contradiction motivated Miller and two University of Washington researchers to investigate how fetal alcohol syndrome affects the corpus callosum in macaques, primates that closely resemble humans. The team analyzed 15 post-puberty macaques affected to varying degrees by maternal alcohol consumption during gestation. The findings were published in the September 13 issue of the Journal of Comparative Neurology.

Using magnetic resonance imaging (MRI) and post-mortem analyses, the team found that offspring of macaque mothers fed 170 - 270 milligrams (mg) of alcohol per deciliter of blood (sufficient to bring blood alcohol concentrations to .17 to .27 mg percent) for several weeks or months had more axons in their corpus callosums than did control animals. These axons conduct signals from one side of the brain to the other. In contrast, Miller said, the research on humans affected by fetal alcohol syndrome was generally based on extreme cases in which the mothers' b

Contact: Becky Soglin
University of Iowa

Page: 1 2 3

Related medicine news :

1. First head-to-head study to compare lidoderm patch and Celebrex in treating pain
2. UMaine study looks at infants and chronic nighttime crying
3. Chronic pain treatments more effective when taken together, new study shows
4. UNC study: Most N.C. family practitioners engage in unrecognized community service
5. New study in Nature demonstrates protection against cell death during heart attack
6. UCSF study offers insight into human circadian rhythms
7. International breast cancer prevention study launches in the United States and Canada
8. UW study shows blacks and Latinos are more satisfied with physicians of the same race
9. Physicians may not be accurate in their confidence levels of their diagnoses, says Pitt study
10. Advertising by academic medical centers may risk eroding public trust, says study
11. Fat may promote inflammation, new study suggests

Post Your Comments:

(Date:10/13/2017)... VA (PRWEB) , ... October 13, 2017 , ... ... of DevOps and Agile Software Development, has been awarded a contract by the ... Blanket Purchase Agreement (BPA) aims to accelerate the enterprise use of Agile methodologies ...
(Date:10/12/2017)... Francisco, CA (PRWEB) , ... October 12, 2017 ... ... Dr. Cheng, are now treating sleep apnea using cutting-edge Oventus O2Vent ... apnea, a serious sleep disorder characterized by frequent cessation in breathing. Oral appliances ...
(Date:10/12/2017)... ... October 12, 2017 , ... The American College of ... Carol Friedman, PhD, FACMI, during the Opening Session of AMIA’s Annual Symposium in Washington, ... In honor of Morris F. Collen, a pioneer in the field of medical informatics, ...
(Date:10/12/2017)... ... ... HMP , a leader in healthcare events and education, today announced that ... for ‘Best B-to-B Healthcare Website.’ Winners were announced during the Eddie & Ozzie Awards ... recognizes editorial and design excellence across a range of sectors. This year’s program included ...
(Date:10/12/2017)... ... 2017 , ... Health Literacy Innovations (HLI), creator of the ... the Cancer Patient Education Network (CPEN), an independent professional organization that shares best ... alliance. , As CPEN’s strategic partner, HLI will help support CPEN members ...
Breaking Medicine News(10 mins):
(Date:9/23/2017)... 22, 2017 Janssen Biotech, Inc. (Janssen) announced ... from the U.S. Food and Drug Administration (FDA) for ... for the treatment of moderately to severely active rheumatoid ... data are needed to further evaluate the safety of ... RA. "We ...
(Date:9/22/2017)... AVACEN Medical (AVACEN) announced that its CE-Marked ... those with the widespread pain associated with fibromyalgia in ... Essex, England commented, "I had ... no sleep at all, tremendous pain, with every movement ... [the AVACEN 100] enough, how this has and is ...
(Date:9/19/2017)... , Sept. 19, 2017   ZirMed Inc ., a ... today announced that it has been ranked #1 by its ... Book™ Rankings 2017 User Survey. ZirMed was recognized as ... large hospitals and medical centers over 200 beds and holds ... healthcare technology user survey history. ...
Breaking Medicine Technology:
Cached News: