HOME >> MEDICINE >> NEWS
UK Researchers Receive $1.14 Million NIH Grant To Study A Molecule That May Have A Role In Diseases Involving Oxidative Cell Death

Researchers at the University of Kentucky College of Allied Health Professions and the UK College of Pharmacy recently received a four-year grant of $1,142,326 from the National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health, to examine the role the molecule cyclic ADP-ribose (cADPR) plays in signaling pathways leading to cell death.

"Cyclic ADP-ribose is an exciting new lead in the area of cellular signaling," said Myron Jacobson, Ph.D., professor, UK College of Pharmacy, and faculty affiliate of UK's Advanced Science and Technology Commercialization Center (ASTeCC). "Our pilot data show that it is involved in cell responses to damage that occurs in heart attack, stroke and neurodegenerative diseases and possibly in the development of cancer."

When the DNA in a cell is damaged, a complex set of cellular signaling pathways begins. These pathways can lead to repair of the damage, programmed cell death (apoptosis), or cell death accompanied by inflammation (necrosis).

Many major diseases involve these signaling pathways either through not enough activation of the pathways, as in cancer, or too much activation, as in heart attack and stroke.

A disruption in the regulation of calcium ions can lead to apoptosis, particularly with oxidative stress, or cell damage caused by molecules that are highly reactive forms of oxygen such as free radicals and peroxides. This coupled with the discovery, about 10 years ago, that cADPR is involved in the regulation of calcium ions, led the Jacobson research team to hypothesize that cADPR may be a key component in cell death, particularly in those situations involving oxidative stress, such as heart attack and stroke.

The research team, led by Jacobson and Elaine Jacobson, Ph.D., professor, Department of Clinical Sciences, UK College of Allied Health Professions, member of the UK Markey Cancer Center, and faculty affilia
'"/>

Contact: Maureen McArthur
mhmcar2@pop.uky.edu
606-323-6363
University of Kentucky Medical Center
3-May-1999


Page: 1 2

Related medicine news :

1. Researchers search for first sign of congestive heart failure
2. Researchers say breast cancer in Africa may provide clues to the disease in African-Americans
3. Researchers close in on breast cancer vaccine
4. Researchers discover link between insulin and Alzheimers
5. Researchers model brains electrical storm during a seizure
6. Researchers track programs success in curbing aggressive behavior
7. Researchers confirm Vioxx nearly doubled cardiovascular risks in cancer prevention study
8. Researchers offer emergency workers a lifeline
9. Researchers discover genetic variant that may explain why women develop M.S. more than men
10. Researchers map the sexual network of an entire high school
11. Researchers hope monkeys can provide new insights into depression

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... BASKING RIDGE, N.J. (PRWEB) , ... October 13, 2017 , ... ... second annual Holly Day Market. Featuring a collection of specialty vendors and unique items ... myriad of personalized and quality-focused health and wellness services offered by the VNA. ...
(Date:10/13/2017)... ... 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh, ... and least understood books in the Holy Scriptures, Revelation. The Book of Revelation paints ... for centuries. Many have tossed it off as mere rubbish, but Yisrayl Hawkins says ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the Mountains to ... to save lost souls in the Philippines. “The Journey: From the Mountains to the ... teacher of the Bible. She has taught all ages and currently teaches a class ...
(Date:10/12/2017)... CA (PRWEB) , ... October 12, 2017 , ... ... Cheng, are now treating sleep apnea using cutting-edge Oventus O2Vent technology. ... a serious sleep disorder characterized by frequent cessation in breathing. Oral appliances can ...
(Date:10/12/2017)... ... October 12, 2017 , ... IsoComforter, Inc. ( https://isocomforter.com ), one ... an innovative new design of the shoulder pad. The shoulder pad provides optimal ... controlling your pain while using cold therapy. By utilizing ice and water that is ...
Breaking Medicine News(10 mins):
(Date:10/5/2017)... Ill. , Oct. 5, 2017  In ... Association of Oral and Maxillofacial Surgeons (AAOMS) released ... opioids – to be used as a first-line ... pain. Recognizing ... the AAOMS White Paper "Opioid Prescribing: Acute and ...
(Date:10/2/2017)... 2017 Diplomat Pharmacy, Inc. (NYSE: ... Consulting, LLC , and named its founder as Diplomat,s ... Tennessee , will operate under Diplomat ... service offerings for health care partners to include IT ... "In an interoperable world, technology delivers comprehensive ...
(Date:10/2/2017)... -- The Rebound mobile app is poised to become a ... of prescription drug addiction. The app empowers users to develop ... down their dosage in a safe, controlled manner while maximizing ... first 100,000 people to sign up will enjoy 3 months ... ...
Breaking Medicine Technology:
Cached News: