HOME >> MEDICINE >> NEWS
UT Southwestern researchers find clue to understanding tolerance to drugs of abuse

DALLAS Sept. 23, 2002 Researchers at UT Southwestern Medical Center at Dallas and their colleagues have uncovered new information that will help brain researchers better understand a person's tolerance to drugs of abuse and open new avenues of investigation into the relationship of addictive-drug usage and the biological causes of mood disorders.

Dr. Michel Barrot, assistant professor of psychiatry at UT Southwestern and lead author of the paper, said researchers used genetically altered mice to show that pain both physiological and psychological as well as pleasure can activate changes in the nucleus accumbens, the forebrain structure critical for reward and motivation processes. The findings appeared in a recent issue of Proceedings of the National Academy of Sciences.

Senior author Dr. Eric Nestler, chairman of psychiatry at UT Southwestern, had previously established that drugs of abuse activate CREB, a specific binding protein known for playing a role in the plasticity and adaptation of nerves in the nucleus accumbens. This action between a drug and a binding site is involved with the learning processes and can affect the interaction between subject and environment.

Barrot worked with Nestler on the earlier research that laid the scientific basis for the study in Proceedings.

Researchers reported that they used viral-mediated gene transfer to deliver and overexpress CREB locally, thus mimicking the CREB hyperactivity seen after the delivery of drugs of abuse or exposure to stress. The mice were then tested for their sensitivity to rewards, such as morphine or sucrose, as well as for their sensitivity to anxiety-causing negative situations or painful stimuli.

"In the paper we show that inducing local CREB hyperactivity decreases the emotional response of an animal in different ways, including those that are rewarding, aversive, anxiety-provoking or hurtful," Barrot said. "On the other hand, a decrease in activ
'"/>

Contact: Ann Harrell
Ann.Harrell@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
23-Sep-2002


Page: 1 2

Related medicine news :

1. NASA awards $9.8 million NSCOR grant to UT Southwestern to study effects of space radiation exposure
2. UT Southwestern doctors track Oklahoma Alzheimers patients via telemedicine
3. Auditory screening for newborns can be successful, UT Southwestern researchers report
4. Exercise helps reduce symptoms of depression, UT Southwestern researchers find
5. UT Southwestern researchers find calcium intake contributing factor in formation of kidney stones
6. UT Southwestern Moncrief Cancer Center is first in Texas to treat patients with TomoTherapy
7. Donald W. Reynolds Foundation awards UT Southwestern $12 million to continue Dallas Heart Study
8. Patients with severe depression improve using guidelines developed by UT Southwestern researchers
9. UT Southwesterns Dr. Charles Pak receives international award for kidney-stone research
10. Excess body weight linked to formation of uric acid kidney stones, UT Southwestern researchers find
11. UT Southwestern researchers discover first effective treatment for exercise disorder

Post Your Comments:
(Date:10/25/2014)... Minneapolis, Minnesota (PRWEB) October 25, 2014 ... a testing firm which verifies IT-accessibility for disabled ... their Access Approved® logo to Mackin Educational ... digital resource management system and to the ... for the "Own Best Medicine" website. ...
(Date:10/25/2014)... 25, 2014 Mesothelioma researchers are reporting ... receive pemetrexed (Alimta), after his combination drug therapy became ... story , just posted on the Surviving Mesothelioma website. ... Medical Center in Japan suggests that “maintenance therapy” with ... who cannot tolerate higher doses of cisplatin. ...
(Date:10/25/2014)... Researchers who discovered antibiotics in farmed and wild ... The use of antibiotics in animals, including ... to the development of antibiotic-resistant bacteria that threaten ... study. Each year in the United States, ... kill about 23,000, according to the Infectious Diseases ...
(Date:10/22/2014)... At a time when the national concussion ... at all levels, the UPMC Sports Medicine Concussion ... where two powerful messages are lost: Concussions can be ... full recoveries every day. , In striving to shift ... research, UPMC and the Concussion Program are unveiling the ...
(Date:10/22/2014)... Springfield, Va. (PRWEB) October 22, 2014 For ... way to make money; it’s an extension of her life’s ... her latest venture as the owner of FirstLight HomeCare, make ... , “It’s important to me that my work makes a ... always harbored an entrepreneurial spirit, so after much research, I ...
Breaking Medicine News(10 mins):Health News:IT-Accessibility Award Granted to Education and Health Care for Section 508/WCAG 2Health News:IT-Accessibility Award Granted to Education and Health Care for Section 508/WCAG 3Health News:New Report Illustrates Extended Mesothelioma Survival with “Maintenance Therapy”, According to Surviving Mesothelioma 2Health News:Researchers Say Antibiotics in Fish a Health Concern 2Health News:University of Pittsburgh Medical Center Launches Initiative to Emphasize Concussions Are Treatable 2Health News:University of Pittsburgh Medical Center Launches Initiative to Emphasize Concussions Are Treatable 3Health News:University of Pittsburgh Medical Center Launches Initiative to Emphasize Concussions Are Treatable 4Health News:Dr. Iris Hunter to Host Grand Opening of FirstLight HomeCare Tomorrow 2
(Date:10/22/2014)... 2014 A new report by ... type, Form, End user, Application and Geography) - Size, ... Report, Opportunities, Segmentation and Forecast, 2013 - 2020", considers ... on key trends tracked, it is anticipated that the ... by 2020, registering a CAGR of 6.2% from 2014 ...
(Date:10/22/2014)... 2014  With a vision to ensure safety ... Global Pharmaceutical and Biotech manufacturer selects and implements ... solution to protect their animal health brand.  ... Photo - http://photos.prnewswire.com/prnh/20141021/153439 ... aggregated by the Xyntek and Antares solution is ...
(Date:10/22/2014)...   BioNano Genomics , the genome mapping ... to purchase an Irys™ System . Among them ... (NCI), NIH Intramural Sequencing Center (NISC) and Genoscope (The ... comprehensive view of a genome was a major ... deliver the scalability or reliability to detect and ...
Breaking Medicine Technology:Global Disposable Gloves Market Expected to Grow to $7.9 Billion by 2020 - Allied Market Research 2Global Disposable Gloves Market Expected to Grow to $7.9 Billion by 2020 - Allied Market Research 3Global Disposable Gloves Market Expected to Grow to $7.9 Billion by 2020 - Allied Market Research 4Xyntek and Antares Serialization Solution Protects Pets Too! 2BioNano's Irys System Adopted by Leading Genomics Centers for Comprehensive Detection of Human Genome Structural Variation 2BioNano's Irys System Adopted by Leading Genomics Centers for Comprehensive Detection of Human Genome Structural Variation 3
Cached News: