HOME >> MEDICINE >> NEWS
UT Southwestern researchers find clue to understanding tolerance to drugs of abuse

DALLAS Sept. 23, 2002 Researchers at UT Southwestern Medical Center at Dallas and their colleagues have uncovered new information that will help brain researchers better understand a person's tolerance to drugs of abuse and open new avenues of investigation into the relationship of addictive-drug usage and the biological causes of mood disorders.

Dr. Michel Barrot, assistant professor of psychiatry at UT Southwestern and lead author of the paper, said researchers used genetically altered mice to show that pain both physiological and psychological as well as pleasure can activate changes in the nucleus accumbens, the forebrain structure critical for reward and motivation processes. The findings appeared in a recent issue of Proceedings of the National Academy of Sciences.

Senior author Dr. Eric Nestler, chairman of psychiatry at UT Southwestern, had previously established that drugs of abuse activate CREB, a specific binding protein known for playing a role in the plasticity and adaptation of nerves in the nucleus accumbens. This action between a drug and a binding site is involved with the learning processes and can affect the interaction between subject and environment.

Barrot worked with Nestler on the earlier research that laid the scientific basis for the study in Proceedings.

Researchers reported that they used viral-mediated gene transfer to deliver and overexpress CREB locally, thus mimicking the CREB hyperactivity seen after the delivery of drugs of abuse or exposure to stress. The mice were then tested for their sensitivity to rewards, such as morphine or sucrose, as well as for their sensitivity to anxiety-causing negative situations or painful stimuli.

"In the paper we show that inducing local CREB hyperactivity decreases the emotional response of an animal in different ways, including those that are rewarding, aversive, anxiety-provoking or hurtful," Barrot said. "On the other hand, a decrease in activ
'"/>

Contact: Ann Harrell
Ann.Harrell@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
23-Sep-2002


Page: 1 2

Related medicine news :

1. NASA awards $9.8 million NSCOR grant to UT Southwestern to study effects of space radiation exposure
2. UT Southwestern doctors track Oklahoma Alzheimers patients via telemedicine
3. Auditory screening for newborns can be successful, UT Southwestern researchers report
4. Exercise helps reduce symptoms of depression, UT Southwestern researchers find
5. UT Southwestern researchers find calcium intake contributing factor in formation of kidney stones
6. UT Southwestern Moncrief Cancer Center is first in Texas to treat patients with TomoTherapy
7. Donald W. Reynolds Foundation awards UT Southwestern $12 million to continue Dallas Heart Study
8. Patients with severe depression improve using guidelines developed by UT Southwestern researchers
9. UT Southwesterns Dr. Charles Pak receives international award for kidney-stone research
10. Excess body weight linked to formation of uric acid kidney stones, UT Southwestern researchers find
11. UT Southwestern researchers discover first effective treatment for exercise disorder

Post Your Comments:
(Date:7/3/2015)... ... ... Celebrity Dresses is currently running a promotion through July 30th. Anyone who orders party ... get 10% discount on orders that are over $100. , The promotion is automatically ... or remember redemption codes. , There is a low price guarantee at The ...
(Date:7/2/2015)... ... July 02, 2015 , ... Following the recent report by ... obese Americans outnumber merely overweight Americans, Samir Becic emphatically declared a war on obesity ... society right now," Becic said. "We must understand the magnitude of this discovery. For ...
(Date:7/2/2015)... ... ... With summer in full swing, Americans are flocking to Canada’s many lakes to reel in ... in the world, and it’s easy to understand why. From the Pacific Northwest Coast of ... Recreational fishing is a huge industry, and Americans make up the vast majority of anglers ...
(Date:7/2/2015)... (PRWEB) , ... July 02, 2015 , ... ... the newest shades of the SIGVARIS PERFORMANCE SOCKS. Since the socks were first ... and athletic trainers. Their significant popularity has inspired four new, fun shades including: ...
(Date:7/2/2015)... ... , ... ActiveBunch.com recently launched as a social network created for people with ... lifestyle community, Active Bunch allows users to connect with like-minded fitness enthusiasts from around ... or group events. , The spokesperson for Active Bunch explained the idea behind ...
Breaking Medicine News(10 mins):Health News:Celebrity Fashion Summer Party Dresses on sale at TheCelebrityDresses.com 2Health News:Samir Becic's Health Fitness Revolution Declares War Against Obesity in America 2Health News:Samir Becic's Health Fitness Revolution Declares War Against Obesity in America 3Health News:Samir Becic's Health Fitness Revolution Declares War Against Obesity in America 4Health News:SIGVARIS is Sporting Four Brand New Colors in the Popular PERFORMANCE SOCK Product Line 2Health News:ActiveBunch.com Launches as a Social Community for People with Active Lifestyles 2
(Date:7/3/2015)... , July 3, 2015 ... bekannt, vorbehaltlich bestimmter Abschlussbedingungen eine 100-prozentige Beteiligung ... zu haben. Mit dieser Übernahme dringt Lupin ... einem Umsatz von 765 Mrd. RUB im ... der Welt gehörte (IMS Health). Seit über ...
(Date:7/2/2015)... , July 2, 2015 Leading organizations ... capture critical product and market insights in internal ... to employee-based studies, it is essential for executives ... internal employees to capture critical business-related insights. ... firm, Best Practices, LLC, most benchmarked companies find ...
(Date:7/2/2015)... NYACK, N.Y. , July 2, 2015  Before you ... plan ahead so you can stay safe and healthy. Take ... plants #summersafety. Infographic http://nyackhospital.org/summersafety Protect Your ... rays from the sun can increase your risk of skin ... the shade as much as possible, especially during midday hours. ...
Breaking Medicine Technology:Lupin übernimmt Biocom aus Russland 2Lupin übernimmt Biocom aus Russland 3Leveraging Employee Insights to Produce Cutting-Edge Market Research 2First Aid Summer Survival Tips from Nyack Hospital 2First Aid Summer Survival Tips from Nyack Hospital 3
Cached News: