HOME >> MEDICINE >> NEWS
UT Southwestern researchers find clue to understanding tolerance to drugs of abuse

DALLAS Sept. 23, 2002 Researchers at UT Southwestern Medical Center at Dallas and their colleagues have uncovered new information that will help brain researchers better understand a person's tolerance to drugs of abuse and open new avenues of investigation into the relationship of addictive-drug usage and the biological causes of mood disorders.

Dr. Michel Barrot, assistant professor of psychiatry at UT Southwestern and lead author of the paper, said researchers used genetically altered mice to show that pain both physiological and psychological as well as pleasure can activate changes in the nucleus accumbens, the forebrain structure critical for reward and motivation processes. The findings appeared in a recent issue of Proceedings of the National Academy of Sciences.

Senior author Dr. Eric Nestler, chairman of psychiatry at UT Southwestern, had previously established that drugs of abuse activate CREB, a specific binding protein known for playing a role in the plasticity and adaptation of nerves in the nucleus accumbens. This action between a drug and a binding site is involved with the learning processes and can affect the interaction between subject and environment.

Barrot worked with Nestler on the earlier research that laid the scientific basis for the study in Proceedings.

Researchers reported that they used viral-mediated gene transfer to deliver and overexpress CREB locally, thus mimicking the CREB hyperactivity seen after the delivery of drugs of abuse or exposure to stress. The mice were then tested for their sensitivity to rewards, such as morphine or sucrose, as well as for their sensitivity to anxiety-causing negative situations or painful stimuli.

"In the paper we show that inducing local CREB hyperactivity decreases the emotional response of an animal in different ways, including those that are rewarding, aversive, anxiety-provoking or hurtful," Barrot said. "On the other hand, a decrease in activ
'"/>

Contact: Ann Harrell
Ann.Harrell@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
23-Sep-2002


Page: 1 2

Related medicine news :

1. NASA awards $9.8 million NSCOR grant to UT Southwestern to study effects of space radiation exposure
2. UT Southwestern doctors track Oklahoma Alzheimers patients via telemedicine
3. Auditory screening for newborns can be successful, UT Southwestern researchers report
4. Exercise helps reduce symptoms of depression, UT Southwestern researchers find
5. UT Southwestern researchers find calcium intake contributing factor in formation of kidney stones
6. UT Southwestern Moncrief Cancer Center is first in Texas to treat patients with TomoTherapy
7. Donald W. Reynolds Foundation awards UT Southwestern $12 million to continue Dallas Heart Study
8. Patients with severe depression improve using guidelines developed by UT Southwestern researchers
9. UT Southwesterns Dr. Charles Pak receives international award for kidney-stone research
10. Excess body weight linked to formation of uric acid kidney stones, UT Southwestern researchers find
11. UT Southwestern researchers discover first effective treatment for exercise disorder

Post Your Comments:
(Date:3/1/2015)... Researchers say working around asbestos-containing construction products ... workers contract malignant mesothelioma. Surviving Mesothelioma has just posted ... Click here to read it now. , ... monitored 17,345 sheet metal workers from 1986 to 2010 ... of mesothelioma or another asbestos-related disease . , ...
(Date:3/1/2015)... 01, 2015 The number of transvaginal ... the past few weeks in two New Jersey litigations ... claims, the Firm announces. , A Case List ... the Bergen County proceeding established for products manufactured by ... few weeks earlier, when 90 fewer cases had been ...
(Date:3/1/2015)... 01, 2015 “ The Barrel Mill ” ... Report, which takes a look at the latest and coolest ... host of NewsWatch and a technology expert, conducted the review ... flavor to drinks. , According to Home Distillation of Alcohol, ... spirits. Well, there’s a pretty cool product that’ll help anyone ...
(Date:2/28/2015)... The MCA Youth Empowerment Conference aims to bridge youths ... towards the goal for a better future for all ... smaller groups will be held after the conference with ... Healthcare, Social and Volunteerism, Women and Youth Empowerment, to ... , Young adults aged between 18-30 years that have ...
(Date:2/28/2015)... February 28, 2015 In a recent ... of Game Change Athlete Development Services ... about the benefits of athlete development and player engagement ... the unique challenges that athletes face and how off-field ... success. , Fletcher became involved in athlete development issues ...
Breaking Medicine News(10 mins):Health News:New Study Finds Indirect Asbestos Exposure Can Raise Mesothelioma Risk for Sheet Metal Workers, According to Surviving Mesothelioma 2Health News:Bernstein Liebhard LLP Comments on Case List Growth in New Jersey Transvaginal Mesh Litigations, Where Firm Attorneys are Representing Hundreds 2Health News:Bernstein Liebhard LLP Comments on Case List Growth in New Jersey Transvaginal Mesh Litigations, Where Firm Attorneys are Representing Hundreds 3Health News:Bernstein Liebhard LLP Comments on Case List Growth in New Jersey Transvaginal Mesh Litigations, Where Firm Attorneys are Representing Hundreds 4Health News:An Oak Infusion Spiral was Featured on NewsWatch Television on January 30, 2015 2Health News:My Mobile University Appointed Learning Partner for the Upcoming MCA’S First Youth Empowerment Conference Held in Malaysia on March 28, 2015 2Health News:My Mobile University Appointed Learning Partner for the Upcoming MCA’S First Youth Empowerment Conference Held in Malaysia on March 28, 2015 3Health News:My Mobile University Appointed Learning Partner for the Upcoming MCA’S First Youth Empowerment Conference Held in Malaysia on March 28, 2015 4Health News:SCI TV Covers Athlete Development with Duncan Fletcher 2Health News:SCI TV Covers Athlete Development with Duncan Fletcher 3
(Date:2/27/2015)... , Feb. 27, 2015 An aggressive campaign ... cut the rate of infection with a dangerous drug-resistant ... Clostridium difficile, or C.diff, is a bacterium ... inflammation of the colon. A recent article in the ... difficile Infection in the United States ...
(Date:2/27/2015)... February 27, 2015 Report Details ... showing you trends, R&D progress, and predicted revenues ,Where ... What are the commercial prospects for this market and ... revenues and other trends to 2025, discussing data, opportunities ... you assess regenerative medicine : cell-based therapies that ...
(Date:2/27/2015)... , Feb. 27, 2015  In recognition of Rare ... to the global bleeding disorders community, CSL Behring ... international units (IUs) of protein therapies to the World ... profit organization which has worked to improve the lives ... The donation supports the WFH,s Global Alliance for Progress ...
Breaking Medicine Technology:Curb Overuse Of Antibiotics To Reduce Drug-Resistant Superbug 2Curb Overuse Of Antibiotics To Reduce Drug-Resistant Superbug 3Translational Regenerative Medicine: Market Prospects 2015-2025 2Translational Regenerative Medicine: Market Prospects 2015-2025 3Translational Regenerative Medicine: Market Prospects 2015-2025 4Translational Regenerative Medicine: Market Prospects 2015-2025 5Translational Regenerative Medicine: Market Prospects 2015-2025 6Translational Regenerative Medicine: Market Prospects 2015-2025 7Translational Regenerative Medicine: Market Prospects 2015-2025 8CSL Behring Continues Treatment Access Leadership by Donating Bleeding Disorder Protein Therapies IUs to World Federation of Hemophilia 2CSL Behring Continues Treatment Access Leadership by Donating Bleeding Disorder Protein Therapies IUs to World Federation of Hemophilia 3
Cached News: