HOME >> MEDICINE >> NEWS
UT Southwestern researchers find clue to understanding tolerance to drugs of abuse

DALLAS Sept. 23, 2002 Researchers at UT Southwestern Medical Center at Dallas and their colleagues have uncovered new information that will help brain researchers better understand a person's tolerance to drugs of abuse and open new avenues of investigation into the relationship of addictive-drug usage and the biological causes of mood disorders.

Dr. Michel Barrot, assistant professor of psychiatry at UT Southwestern and lead author of the paper, said researchers used genetically altered mice to show that pain both physiological and psychological as well as pleasure can activate changes in the nucleus accumbens, the forebrain structure critical for reward and motivation processes. The findings appeared in a recent issue of Proceedings of the National Academy of Sciences.

Senior author Dr. Eric Nestler, chairman of psychiatry at UT Southwestern, had previously established that drugs of abuse activate CREB, a specific binding protein known for playing a role in the plasticity and adaptation of nerves in the nucleus accumbens. This action between a drug and a binding site is involved with the learning processes and can affect the interaction between subject and environment.

Barrot worked with Nestler on the earlier research that laid the scientific basis for the study in Proceedings.

Researchers reported that they used viral-mediated gene transfer to deliver and overexpress CREB locally, thus mimicking the CREB hyperactivity seen after the delivery of drugs of abuse or exposure to stress. The mice were then tested for their sensitivity to rewards, such as morphine or sucrose, as well as for their sensitivity to anxiety-causing negative situations or painful stimuli.

"In the paper we show that inducing local CREB hyperactivity decreases the emotional response of an animal in different ways, including those that are rewarding, aversive, anxiety-provoking or hurtful," Barrot said. "On the other hand, a decrease in activ
'"/>

Contact: Ann Harrell
Ann.Harrell@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
23-Sep-2002


Page: 1 2

Related medicine news :

1. NASA awards $9.8 million NSCOR grant to UT Southwestern to study effects of space radiation exposure
2. UT Southwestern doctors track Oklahoma Alzheimers patients via telemedicine
3. Auditory screening for newborns can be successful, UT Southwestern researchers report
4. Exercise helps reduce symptoms of depression, UT Southwestern researchers find
5. UT Southwestern researchers find calcium intake contributing factor in formation of kidney stones
6. UT Southwestern Moncrief Cancer Center is first in Texas to treat patients with TomoTherapy
7. Donald W. Reynolds Foundation awards UT Southwestern $12 million to continue Dallas Heart Study
8. Patients with severe depression improve using guidelines developed by UT Southwestern researchers
9. UT Southwesterns Dr. Charles Pak receives international award for kidney-stone research
10. Excess body weight linked to formation of uric acid kidney stones, UT Southwestern researchers find
11. UT Southwestern researchers discover first effective treatment for exercise disorder

Post Your Comments:
(Date:8/30/2014)... "My wife suffered neck, back and spine injuries ... of two inventors from Bethel, Alaska. "The whiplash contributed ... area. She tried other pillows to little avail. The ... comfort and providing extra sleep." , They created a ... head, neck and back comfortably. This enables the user ...
(Date:8/30/2014)... 30, 2014 "My niece developed a ... at any moment, her fever might get worse," said ... me well aware of how she was doing, I ... ALARM to continuously monitor a child's temperature. The unit ... This ensures that prompt medical care can be given, ...
(Date:8/30/2014)... York (PRWEB) August 30, 2014 ... transvaginal mesh lawsuits ( http://www.injurybeacon.com/transvaginal-mesh/ ) filed against ... to sever four cases selected for one of ... issued on August 18, 2014, U.S. District Judge ... West Virginia disagrees with Boston Scientific’s contention that ...
(Date:8/30/2014)... In today’s world, a good night’s sleep has become especially ... (a medical problem where the airway collapses during sleep and ... rest they need to face their daily challenges. , ... people in the United States alone have sleep apnea. Of ... those treated, many cannot tolerate their prescribed medical device known ...
(Date:8/30/2014)... August 30, 2014 Top10BestSEOHosting.com is ... researchers have announced that HostGator.com http://secure.hostgator.com/~affiliat/cgi-bin/affiliates/clickthru.cgi?id=seohosts ... current market. Also, they has announced that Bluehost ... , Hostgator, one of the Top 10 ... of cheap Windows hosting, and it offers rich ...
Breaking Medicine News(10 mins):Health News:Transvaginal Mesh Lawsuit News: Federal Judge Refuses Boston Scientific Request for Separate Trials in Four Bellwether Cases, Bernstein Liebhard LLP Reports 2Health News:Transvaginal Mesh Lawsuit News: Federal Judge Refuses Boston Scientific Request for Separate Trials in Four Bellwether Cases, Bernstein Liebhard LLP Reports 3Health News:Snoring: Bad for Relationships, Bad for Health 2Health News:Snoring: Bad for Relationships, Bad for Health 3Health News:Top10BestSEOHosting.com: HostGator.com Is The Best Windows Hosting Supplier 2
(Date:8/29/2014)... 2014 Medina Medical announced today that Mr. ... the Board of Directors on August 18, 2014. Mr. ... commercialization experience, including over a decade of direct experience ... a Partner of the medical device incubator The Foundry, ... Foundry start-ups. Mr. Engelson previously served as the Chief ...
(Date:8/29/2014)... 29, 2014 Research and Markets ... Cancer Therapeutics Market & Pipeline Insight 2014" report ... developed to prevent and eradicate the prevalence of cancer ... are confined to low specificity, safety and large number ... for a better solution. It has been discovered that ...
(Date:8/29/2014)... -- Research and Markets has announced the ... of Pharmaceutical Equipment Market in China, 2014-2018" report ... Trend Forecast of Pharmaceutical Equipment Market in ... pharmaceutical equipment industry in the aspects of ... business performance of domestic major enterprises, as well as ...
Breaking Medicine Technology:Medina Medical Announces Erik T. Engelson Joins as Chief Executive Officer 2Global Peptide Cancer Therapeutics Market & Pipeline Insight 2014 2Research and Development Trend Forecast of Pharmaceutical Equipment Market in China, 2014-2018 2
Cached News: