HOME >> MEDICINE >> NEWS
Understanding how lymph nodes respond to infection may redefine how immune system functions

DURHAM, N.C. -- Duke University Medical Center researchers may have solved the mystery of why lymph nodes swell when the body fights infection. Their findings may redefine how the immune system functions, they said.

Their research, published in the December 2003 issue of Nature Immunology, centered on the role of mast cells. Mast cells are immune cells that are typically found just under the skin and in the lining of the intestine and lungs and were previously associated primarily with the induction of allergic reactions. The Duke researchers report that allergic reactions are only a side effect of mast cells' much more important role as a regulator of the body's immune system.

"Mast cells serve as the command post for the immune system during infections," said Soman Abraham, Ph.D., professor of pathology, associate professor of immunology and senior author of the paper. "White blood cells are sequestered within these nodes and, following proper activation, they can specifically target infectious agents and aid the host in clearing unwanted pathogens."

Abraham said the discovery that mast cells can initiate the activation and swelling of nodes through release of specific signaling molecules points to the possible use of mast cell products for the development of vaccines designed to boost the potency of the immune response.

"Mast cells have been much maligned because of their contribution to many diseases including asthma, arthritis, Crohn's disease and multiple sclerosis," said Abraham. "Our research shows that mast cells play an important role in immune surveillance and defense against infectious agents."

The human immune system comprises two components that protect it against invading pathogens. The first line of defense is the innate immune system, a quick-acting response triggered immediately when a pathogen enters the body. The innate immune response responds the same regardless of the pathogen and attacks the pathogen fo
'"/>

Contact: Amy Austell
amy.austell@duke.edu
919-684-4148
Duke University Medical Center
20-Nov-2003


Page: 1 2 3

Related medicine news :

1. Understanding how vulnerabilities may keep women in abusive relationships
2. From town planning to intimate sex: Understanding the risks in our lives
3. Understanding how prostaglandin prevents gut injury during radiation therapy
4. Understanding epilepsy
5. The long view: Understanding why cancer strikes late
6. Understanding the autoimmune response in type 1 diabetes
7. Understanding nerve degeneration in spastic paraplegia
8. Understanding Alzheimers disease: Animal research points to new direction for therapy
9. Understanding genetic cancer risk might not help smokers kick the habit
10. Understanding cancer patients needs, concerns, is key to improving clinical trial participation
11. Understanding Why Antibiotics May Be Over-prescribed For Patients With Sore Throats

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent and San Francisco dentists, ... cutting-edge Oventus O2Vent technology. As many as 18 million Americans are estimated to ... breathing. Oral appliances can offer significant relief to about 75 percent of people ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... IsoComforter, Inc. ... products, announced today the introduction of an innovative new design of the shoulder pad. ... so you get maximum comfort while controlling your pain while using cold therapy. By ...
(Date:10/12/2017)... Maryland (PRWEB) , ... October 12, 2017 , ... ... magnetic drug delivery system that we intend to develop to enable prevention of ... can lead to severe hearing loss, especially in pediatric patients. For cisplatin, hearing ...
(Date:10/12/2017)... ... ... Leading pediatric oncology experts at Children’s National Health System will join ... International Society of Paediatric Oncology (SIOP) Oct. 12-15. Chaired by Jeffrey Dome, ... at Children’s National, and Stephen P. Hunger, M.D., Chief of the Division of ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... the nation's first interactive health literacy software tool, and the Cancer Patient Education ... of cancer patient education, today announce a new strategic alliance. , As ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... 4, 2017  South Korean-based healthcare product Development Company ... "cprCUBE" on Kickstarter. The device will educate the user ... with better efficiency compared to the dated and pricey ... on efficacy of the compression for a more informed ... goal to raise $5,000. ...
(Date:10/2/2017)... Lilly and Company (NYSE: LLY ) will ... 2017 on Tuesday, October 24, 2017. Lilly will also ... investment community and media to further detail the company,s ... at 9 a.m. Eastern time. Investors, media and the ... conference call through a link that will be posted ...
(Date:9/28/2017)... , Sept. 28, 2017 Hill-Rom Holdings, ... 2017 earnings conference call and webcast on Friday, November ... a.m. (EDT) and ending at approximately 8:30 a.m. (CDT) ... discussing the company,s 2017 financial performance and guidance for ... opportunities, initiatives to enhance operational performance, and long-range financial ...
Breaking Medicine Technology:
Cached News: