HOME >> MEDICINE >> NEWS
Understanding how prostaglandin prevents gut injury during radiation therapy

People undergoing radiation therapy for diseases such as cancer run the risk of irreversibly damaging the cells of their intestine due to the radiation-induced death of cells within the gut. Previous studies have demonstrated that treatment of mice with protaglandin E2 (PGE2) is capable of inhibiting cell death in the intestine that occurs as a result of exposure to radiation.

In the December 1 issue of the Journal of Clinical Investigation, Teresa Tessner and colleagues from the Washington University School of Medicine pursued the mechanism by which PGE2 protects against radiation-induced injury in mice. They demonstrate that radiation-induced cell death can be dependent or independent of the bax protein, however the beneficial effect of PGE2 treatment is only achieved via a bax-dependent mechanism. Bax is normally expressed in the cell cytoplasm, however in response to radiation exposure, bax relocates to the mitochondrial membrane and trigger cell signaling events that lead to cell death. Administration of PGE2 to radiation-exposed mice was found to activate AKT phosphorylation events that block the relocation of bax within the cell, and therefore prevent cell death.

The data suggest that PGE2 or other drugs that increase AKP phosphorylation should reduce injury to the small intestine during radiation therapy. Conversely, cancers with mutations that inactivate bax and block its relocation to the mitochondria may be resistant to radiation therapy. This work may have significant clinical impact if the use of PGE2 could be shown to be effective for protection against radiation-induced gut injury in humans.


'"/>

Contact: Brooke Grindlinger
press_releases@the-jci.org
212-342-0497
Journal of Clinical Investigation
1-Dec-2004


Page: 1

Related medicine news :

1. Understanding how vulnerabilities may keep women in abusive relationships
2. From town planning to intimate sex: Understanding the risks in our lives
3. Understanding epilepsy
4. The long view: Understanding why cancer strikes late
5. Understanding the autoimmune response in type 1 diabetes
6. Understanding nerve degeneration in spastic paraplegia
7. Understanding how lymph nodes respond to infection may redefine how immune system functions
8. Understanding Alzheimers disease: Animal research points to new direction for therapy
9. Understanding genetic cancer risk might not help smokers kick the habit
10. Understanding cancer patients needs, concerns, is key to improving clinical trial participation
11. Understanding Why Antibiotics May Be Over-prescribed For Patients With Sore Throats

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/22/2018)... ... ... From 1991 to 2012, Works of Heart raised more than one million ... to the generous artists, sponsors, and patrons who supported what became the Triangle’s premier ... HIV/AIDS, about the Alliance of AIDS Services - Carolina, and (now) about Works of ...
(Date:9/22/2018)... Fla. (PRWEB) , ... September 21, 2018 , ... Liz ... speak at the Sept. 25 Hillsborough County Chapter meeting of the Florida Assisted Living ... in Brandon, Florida. , Dudek’s presentation will provide an overview of the success ...
(Date:9/22/2018)... ... September 21, 2018 , ... The Light Up To ... hosting the upcoming Valor Charity Events taking place this weekend, September 21-22. The events ... which will raise awareness and funds to support the rehabilitation and medical needs of ...
(Date:9/22/2018)... ... 2018 , ... Located on the fourth floor in the East Pavilion at ... Monday, October 1. The 8,500 square-foot unit featuring 16 private rooms is the first ... an organization like TGH that provides excellent, innovative care,” said Andrew Molosky, MBA, FACHE, ...
(Date:9/22/2018)... SACRAMENTO, Calif. (PRWEB) , ... September 22, 2018 , ... ... however, is the serious health risk that particularly affects older adults – the risk ... Prevention (CDC):, Every second of the day and adult aged 65 and older falls ...
Breaking Medicine News(10 mins):
(Date:9/13/2018)... , ... September 13, 2018 , ... ... is now available to test and ensure correct implementation of the NCPDP SCRIPT ... Version 2017071 includes important functionality and transactions identified by the industry as vital ...
(Date:9/13/2018)... ... September 13, 2018 , ... Becker's Healthcare is ... , Hospitals and health systems rely on CIOs and IT department leaders to ... data-gathering and cybersecurity initiatives. Those who lead community hospital and health system IT ...
(Date:9/12/2018)... ... ... Lifetime Wellness , a leading provider of person-centered wellness, life enrichment, ... store to offer exclusive aromatherapy products to a wider community. to bring enhanced ... store to offer our custom aromatherapy to not only our residents, but a broader ...
Breaking Medicine Technology:
Cached News: