HOME >> MEDICINE >> NEWS
Understanding nerve degeneration in spastic paraplegia

Hereditary spastic paraplegia (HSP) encompasses a group of neurodegenerative diseases characterized by progressive weakness, spasticity, and diverse patterns of inheritance, which is caused by degeneration of nerve axons. Elena Rugarli and colleagues from the Telethon Institute of Genetics and Medicine in Naples, Italy, developed a mouse model for studying HSP due to mutations in the Spg7 gene, which encodes the enzyme paraplegin. Paraplegin-deficient mice were affected by axonal swelling from failed axon transport, and axon degeneration. Long before this swelling ocurred the authors observed abnormalities in mitochondrial shape within nerve terminals that correlated with the onset of motor skill impairment. The number of axons containing these abnormal mitochondria was far greater than the number of swollen and degenerate axons. The authors suggest that local failure of mitochondrial function may affect axonal transport and cause axonal degeneration.

In an accompanying commentary, Harris Gelbard from the University of Rochester discusses a hypothetical scheme for altered mitochondrial function that may result from the loss of paraplegin activity, which may account for the pathology observed in Spg7-/- mice. A timely therapeutic intervention may therefore prevent axonal loss.


'"/>

Contact: Brooke Grindlinger
science_editor@the-jci.org
212-342-9006
Journal of Clinical Investigation
15-Jan-2004


Page: 1

Related medicine news :

1. Understanding how vulnerabilities may keep women in abusive relationships
2. From town planning to intimate sex: Understanding the risks in our lives
3. Understanding how prostaglandin prevents gut injury during radiation therapy
4. Understanding epilepsy
5. The long view: Understanding why cancer strikes late
6. Understanding the autoimmune response in type 1 diabetes
7. Understanding how lymph nodes respond to infection may redefine how immune system functions
8. Understanding Alzheimers disease: Animal research points to new direction for therapy
9. Understanding genetic cancer risk might not help smokers kick the habit
10. Understanding cancer patients needs, concerns, is key to improving clinical trial participation
11. Understanding Why Antibiotics May Be Over-prescribed For Patients With Sore Throats

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/30/2021)... , ... March 29, 2021 , ... ... the 21st Century , A Virtual Workshop Presented by WCG FDAnews and Cerulean ... 4:30 pm EDT, https://wcg.swoogo.com/modern-sop-and-quality-systems , Are one’s SOPs written for the ...
(Date:3/30/2021)... ... March 29, 2021 , ... According to data released ... reproductive age (13-44) in need of publicly funded contraception live in counties impacted by ... Colorado’s 64 counties have lost some of their Title X resources. , The ...
(Date:3/30/2021)... ... March 29, 2021 , ... Health Literacy Innovations (HLI), a ... confusion due to low health literacy today announces a new partnership with the ... work with ACAP’s member Safety Net Health Plans, those that provide comprehensive health ...
(Date:3/30/2021)... ... ... Dr. Colin Campbell is proud to announce the 1 year anniversary in their new state ... internal medicine and is a primary care specialist who has been practicing for 23 years. ... keep South Jersey healthy one patient at a time. , “Over the past year, Dr. ...
(Date:3/30/2021)... ... March 30, 2021 , ... The COVID-19 ... and survivors; their families; and their caregivers. Crossroads4Hope is addressing the needs of ... emotional support system, MyGo2Support, which meets needs of people impacted by cancer, no ...
Breaking Medicine News(10 mins):
(Date:3/30/2021)... ... March 29, 2021 , ... The University of Texas Health Science Center ... San Antonio Multispecialty and Research Hospital, a destination center for research and treatment of ... In a nod to the COVID-19 pandemic, the ceremony was held virtually. , William ...
(Date:3/30/2021)... ... March 29, 2021 , ... Iora Health ... primary care, has partnered with Devoted Health , one of the fastest-growing ... across Maricopa County and provides seniors with the highest-quality care and experience possible, ...
(Date:3/30/2021)... CITY (PRWEB) , ... March 29, 2021 , ... ... has joined the Vaccine Credential Initiative (VCI), a group bringing together leading health ... record of vaccination status, based on open, interoperable standards. By joining the VCI ...
Breaking Medicine Technology:
Cached News: