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Undisclosed results of clinical trials

This issue of CMAJ includes two commentaries decrying the suppression of data concerning unsafe or ineffective medication.

Jane Garland, a psychiatrist, clinical researcher and past investigator in SSRI trials, states that negative results from SSRI trials go unpublished, while the published evidence to support their use is flimsy at best. She calls on physicianresearchers to take a collective stand and demand disclosure of all data.

In a related commentary, Herxheimer and Mintzes point to flawed trial design, secrecy in the approvals process and inadequate systems for adverse drug reporting as the mechanisms by which ineffective and unsafe drugs gain a place in the market.


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Contact: Dr. Barbara Mintzes
bmintzes@chspr.ubc.ca
Canadian Medical Association Journal
16-Feb-2004


Page: 1

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