HOME >> MEDICINE >> NEWS
Unexpected benefit seen in treating HER-2 breast cancer with new preoperative drug combo

HOUSTON - A new use of the drug Herceptin appears to offer a much more powerful treatment advantage than expected for patients with HER-2-positive breast cancer, say researchers at The University of Texas M. D. Anderson Cancer Center.

When combined with chemotherapy and used before surgery in early stage breast cancer the drug proved so beneficial - eliminating 42 percent more tumors than chemotherapy alone - that the clinical trial testing of this new treatment plan was halted early, the researchers report in the Journal of Clinical Oncology.

"This is a far better result than we had anticipated and seems to suggest that simultaneous use of chemotherapy and Herceptin offers a much more potent treatment than use of these drugs sequentially, or alone," says lead investigator Aman Buzdar, M.D., professor in the Department of Breast Medical Oncology at M. D. Anderson.

"This is the best treatment result we have seen in this patient population," Buzdar says. "It shows that we can potentially change the natural history of a disease that is associated with a high risk of recurrence and death."

He cautions, however, that although this combination of therapies seems to show better efficacy, as well as less risk of heart damage than has been seen before with Herceptin treatment, "the jury is still out on the long-term safety and outcome. As in all such studies, we will need to wait years to follow the progress of our patient participants," Buzdar says.

Details of the trial result, slated for the June issue of the journal, were posted online Feb. 28 because of interest in the study. Preliminary results of the trial were presented in June, 2004 at the annual meeting of the American Society of Clinical Oncology.

After only 34 of a planned 164 patients had completed therapy, the trial's Data Monitoring Committee stopped the clinical trial because of the obvious benefit seen in patients who received Herceptin and chemotherap
'"/>

Contact: Nancy Jensen
nwjensen@mdanderson.org
713-792-0655
University of Texas M. D. Anderson Cancer Center
29-Mar-2005


Page: 1 2 3 4

Related medicine news :

1. Unexpected similarities between raindrops and proteins
2. Unexpected target may unlock the door to fighting sepsis
3. Corrected metabolism leads to health benefits and weight loss
4. Two years after gene therapy treatments, severe angina patients showed prolonged clinical benefit
5. Artery clearing system does not provide benefit for patients undergoing PCI
6. Older women can benefit from chemotherapy to treat breast cancer
7. Flu vaccination benefits people of any age with high-risk medical conditions
8. Clinical breast examination offers modest benefit to breast cancer screening program
9. Patients with previous heart attacks may not benefit from pacemaker implant
10. Computer memory, MRI technology benefit from student research at UH
11. Clinical trial of Etanercept for Wegeners disease shows no benefit

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... , ... Global Healthcare Management’s 4th Annual Kids Fun Run brought out many ... event, sponsored by Global Healthcare Management’s CEO, Jon Letko, is aimed at getting kids ... of all ages; it is a non-competitive, non-timed event, which is all about having ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... ... DevOps and Agile Software Development, has been awarded a contract by the Center ... Purchase Agreement (BPA) aims to accelerate the enterprise use of Agile methodologies in ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... for healthcare compliance program management, will showcase a range of technology and learning ... Assisted Living (NCAL) Convention and Expo to be held October 14–18, 2017 at ...
(Date:10/12/2017)... ... 12, 2017 , ... The company has developed a suite ... regulatory authorities worldwide. From Children’s to Adults 50+, every formula has been developed ... , These products are also: Gluten Free, Non-GMO, Vegan, Soy Free, Non-Dairy*, ...
(Date:10/12/2017)... ... October 12, 2017 , ... Asante, a ... health care, have expanded their existing home health joint venture through an agreement, ... been operating a joint venture home health company with Asante, delivering clinically integrated ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... , Oct. 2, 2017  Eli Lilly and Company ... results for the third quarter of 2017 on Tuesday, ... call on that day with the investment community and ... The conference call will begin at 9 a.m. ... access a live webcast of the conference call through ...
(Date:9/28/2017)... , Sept. 28, 2017 Hill-Rom Holdings, ... 2017 earnings conference call and webcast on Friday, November ... a.m. (EDT) and ending at approximately 8:30 a.m. (CDT) ... discussing the company,s 2017 financial performance and guidance for ... opportunities, initiatives to enhance operational performance, and long-range financial ...
(Date:9/25/2017)...   Montrium , an industry leader in ... IQPC Trial Master Files & Inspection Readiness Conference ... Clinical Services has selected eTMF Connect ... EastHORN, a leading European contract research organization (CRO), ... to enable greater collaboration with sponsors, improve compliance ...
Breaking Medicine Technology:
Cached News: