University Of Pittsburgh Cancer Institute Defines First Immunologic Markers Of Interferon Effectiveness Against Melanoma

PITTSBURGH, May 17 -- For the first time, investigators have correlated the use of interferon alfa 2b (IFNa2b) with specific immune responses in patients treated with high doses of this agent to prevent the recurrence of melanoma. These findings, part of a landmark multi-center study based at the University of Pittsburgh Cancer Institute (UPCI), begin to account for the impact of IFNa2b on relapse-free survival among study patients. The results shed light on how this biological therapy works and provide signposts that could one day help clinicians pinpoint which patients will benefit from therapy, according to the investigators, who are presenting their preliminary findings Monday, May 17, at the annual meeting of the American Society of Clinical Oncology in Atlanta.

"This is the first attempt to make immunologic sense of the effects of IFNa2b on patients receiving this drug to prevent the recurrence of melanoma," said John Kirkwood, M.D., professor of medicine at the University of Pittsburgh and director of UPCI's Melanoma Center. "We found evidence that high-dose IFNa2b modulated the body's expression of cell markers called MHC Class II antigens on tumor tissues. These markers are necessary for the anti-tumor activity of one group of immune cells, or helper T cells. High-dose interferon also increased the response of a special set of immune cells, called natural killer cells, which may be more broadly active against melanoma cells."

Interferons are biological response modifiers produced naturally by the body to fight infections and tumors. IFNa2b is manufactured for use in cancer treatment studies, and can cause flu-like symptoms and depression in people receiving it.

The immunologic findings were made during a large study of high-dose IFNa2b, low-dose IFNa2b or observation for patients with surgically removed melanoma considered at high risk of recurrence. Results of this study have shown that recipients of a yearlong course of high-dose

Contact: Lauren Ward
University of Pittsburgh Medical Center

Page: 1 2

Related medicine news :

1. Indiana University researchers closer to helping hearing-impaired using stem cells
2. Boston University team finds link between high cholesterol and better cognitive performance
3. University seeks recruits for arthritis study
4. University of Manchester awarded 826k for brain science and mental health research
5. $4 million grant boosts University of Michigan campaign for a new childrens hospital
6. Lead in the environment causes violent crime, reports University of Pittsburgh researcher at AAAS
7. Next generation body scanner launched by the University of Manchester
8. University of Washington joins new Autism Treatment Network to provide better medical services
9. Binghamton University launches microelectronics research center
10. University of Manchester makes made-to-measure skin and bones a reality using inkjet printers
11. RelayHealth selected by Columbia University to link doctors and patients online

Post Your Comments:

(Date:11/19/2019)... ... November 19, 2019 , ... Bright Day Big Blocks, http://www.brightdaybigblocks.com ... announcing the launch of their Gift Of Play initiative. Organizations are encouraged to ... , Co-Founders of Bright Day Big Blocks, Laurel Tucker and David Krishock decided earlier ...
(Date:11/19/2019)... Calif. (PRWEB) , ... November ... ... leading provider of online B2B marketplaces for the scientific and healthcare industries, ... ABM publications, Advantage Business Marketing (previously known as Advantage Business Media) ceased ...
(Date:11/16/2019)... ... November 15, 2019 , ... At their 36th Annual ... Hospital raised more than $750,000 for programs and services benefiting Calvary patients and their ... event also featured entertainment from The Chiffons, and Shirley Alston Reeves, original lead singer ...
(Date:11/16/2019)... ... November 15, 2019 , ... As demand for legal ... cannabis via well-managed dispensaries becomes more and more important, both for consumers and ... of state-of-the-art, online, custom cannabis business plans is now increasing its support for ...
(Date:11/15/2019)... ... November 15, 2019 , ... Anxiety ... of America (ADAA) puts the current figures of adults who suffer at ... mental health issues manifest in many different ways, including Post Traumatic Stress Disorder ...
Breaking Medicine News(10 mins):
(Date:11/19/2019)... ... November 19, 2019 , ... Creative Safety ... a new complementary guide to industrial floor marking . , This ... of your floor tape, paint, and signs. From creative applications to product recommendations ...
(Date:11/16/2019)... ANGELES (PRWEB) , ... November 15, 2019 , ... Cosmetic ... were performed in 2018. While patients continue to undergo cosmetic procedures all throughout the ... by the doctor or the facility, anesthesia fees and the extent of the work ...
(Date:11/15/2019)... ... November 15, 2019 , ... Mold doesn’t need things to ... moisture that isn’t necessarily detectable to the eye or by touch. ServPro in ... nothing is wet” by explaining the conditions that mold needs to grow and how ...
Breaking Medicine Technology:
Cached News: