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University Of Pittsburgh Cancer Institute Defines First Immunologic Markers Of Interferon Effectiveness Against Melanoma

IFNa2b are more likely to remain free of disease than counterparts who receive low-dose IFNa2b or no therapy at all after initial surgery.

"By knowing how the immune system of a melanoma patient typically responds to high-dose IFNa2b within a few months of administration, we may better select patients who are likely to benefit from this therapy and steer those patients who are not responding using these parameters to other therapies that may provide them a greater benefit," added Dr. Kirkwood.

Dr. Kirkwood and Hassane Zarour, M.D., a UPCI research associate who is presenting this study at the ASCO meeting, are extending their research in recipients of high-dose IFNa2b to look for tumor antigens that may play a role in up-regulating the expression of class II MHC to better stimulate the anti-cancer activity of helper T cells.


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Contact: Lauren Ward
wardle@msx.upmc.edu
412-624-2607
University of Pittsburgh Medical Center
17-May-1999


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