University of Kentucky Markey Cancer Center Researchers Awarded Grant To Fight Leukemia Recurrence

LEXINGTON, KY (Sept. 1, 1998) - Imagine sparing leukemia patients a second round of chemotherapy. That's what University of Kentucky Markey Cancer Center researchers hope to do with a three-year, $321,459 grant from the Leukemia Society of America. Craig Jordan, Ph.D., assistant professor of medicine, UK College of Medicine, and John Yanelli, Ph.D., associate professor of internal medicine, UK College of Medicine, will use the money to design gene therapy-based treatments to help leukemia patients avoid recurrence of the disease.

Despite recent advances in treatment, cancer recurrence remains a long-term problem. Cancer cells often travel throughout the body, thus, some malignant cells may escape chemical or surgical removal. To tackle this problem, Jordan and Yanelli have devised a method to prevent relapse by allowing the patient's immune system to "mop up" residual tumor cells in the bloodstream. It's based on a promising technique called immunotherapy. Used to treat other cancer types, immunotherapy targets immune cells to attack a disease.

"We're going to educate the immune system in the lab," Jordan said. "We've invented a new technology to genetically change the tumor cell."

The researchers plan to extract tumor cells from a patient, culture them, and then using a virus as a transfer agent, will introduce human genes into the cell. The genes are selected for their ability to generate an immune response toward cancer cells.

The cultured cells then would be crippled by radiation - the cells will not die, but will lose the ability to reproduce. After patients complete a standard regime of chemotherapy, the irradiated tumor cells will be reinfused into their body.

Researchers hope the genetically engineered cells will rev up the patient's immune system to seek and destroy any remaining cancer cells.

The procedure should be almost completely nontoxic, Jordan said. It would eliminate a second round of chemotherapy for patients, reduce

Contact: krcumb0@pop.uky.edu
(606) 323-6363
University of Kentucky Medical Center

Page: 1 2

Related medicine news :

1. Indiana University researchers closer to helping hearing-impaired using stem cells
2. Boston University team finds link between high cholesterol and better cognitive performance
3. University seeks recruits for arthritis study
4. University of Manchester awarded 826k for brain science and mental health research
5. $4 million grant boosts University of Michigan campaign for a new childrens hospital
6. Lead in the environment causes violent crime, reports University of Pittsburgh researcher at AAAS
7. Next generation body scanner launched by the University of Manchester
8. University of Washington joins new Autism Treatment Network to provide better medical services
9. Binghamton University launches microelectronics research center
10. University of Manchester makes made-to-measure skin and bones a reality using inkjet printers
11. RelayHealth selected by Columbia University to link doctors and patients online

Post Your Comments:

(Date:8/31/2020)... ... August 31, 2020 , ... Ocean Springs, Mississippi-based pharmaceutical distributor ... first responders across the United States. Since the start of the global COVID-19 ... medical centers , hospitals , firefighters , and public ...
(Date:8/31/2020)... ... August 31, 2020 , ... ... services to dental groups in the United States, today announced the grand opening ... Beaumont, CA. , Patients will enjoy convenient hours, a comfortable office, and ...
(Date:8/31/2020)... ... August 31, 2020 , ... Dr. Chang has over ... autism and other developmental disabilities, as well as supporting staff in caring for ... autism, school consultation, and staff development. She joined the company in 2015 as ...
(Date:8/28/2020)... ... August 28, 2020 , ... ... designed to help treat patients with respiratory conditions, including COVID-19, while reducing the ... and oxygen, but it captures exhaled gas and scrubs it free of carbon ...
(Date:8/28/2020)... ... , ... Ziegler, a specialty investment bank, is pleased to ... a tech-enabled behavioral health and well-being solutions provider. , Synchronous Health, a ... (AI) to increase access and quality of behavioral health services, and Adventist Health, ...
Breaking Medicine News(10 mins):
(Date:8/31/2020)... ... August 31, 2020 , ... If you live in New York City you will always pay ... sense, it’s the law of supply and demand, but are plastic surgeons in New York ... percentage of their patients that make the four-hour trip to have expert aesthetic treatments by ...
(Date:8/28/2020)... ... 2020 , ... Dr. Raheleh Sarbaziha has been reimagining the ... Armed with her qualifications from Ross University School of Medicine and the University ... body with the nation and world. With a fellowship in Integrative Medicine Dr. ...
(Date:8/27/2020)... ATLANTA (PRWEB) , ... August 27, 2020 , ... ... outcomes analytics, has partnered with Enquire, a leading provider of cloud CRM, marketing ... The two organizations' strategic partnership will involve the integration of Trella’s performance intelligence ...
Breaking Medicine Technology:
Cached News: