HOME >> MEDICINE >> NEWS
University of Manchester uses crystals to help battle deadly diseases

A groundbreaking technique developed at The University of Manchester, which uses crystals to map 'invisible' parts of molecules, is set to revolutionise drug discovery.

The technique, which involves sending beams of neutrons through crystals at freezing temperatures, just a few degrees above 'absolute zero', will for the first time allow scientists to see complete structures of protein molecules, right down to the last atom.

The problem faced by scientists using current methods is the fact that it is not possible to detect every atom in a protein's molecular structure, and the structures therefore are incomplete making drug design more difficult.

Professor John R. Helliwell, Professor of Structural Chemistry, who led the research, said: "This has raised the stakes in the world of drug discovery. This methodology will make research in the field more powerful, more effective and more efficient."

The breakthrough allows the molecular structures of proteins, the chemical catalysts in the body, to be studied in complete detail. In fact, experiments at the University have shown that the number of visible atoms in a molecule doubled when using the technique, compared to techniques used today.

Protein Crystallography is an important tool used to determine the three-dimensional structures of proteins. Once a pharmaceutical company has this information, it is able to tailor drugs to target specific proteins, eg interfering with the function of such proteins in infectious agents like tuberculosis - enabling the production of more effective medicines.

'Ultra-Cold Neutron Protein Crystallography' improves on current methods by probing protein structures with neutrons at temperatures of 15K (-258 degrees C), dramatically increasing the number of visible atoms. The process especially reveals the hydrogen atoms, which hold the key to many chemical reactions, and because of their low mass, are rarely revealed by current methods like
'"/>

Contact: Simon Hunter
simon.hunter-2@manchester.ac.uk
44-161-275-8387
University of Manchester
23-Nov-2004


Page: 1 2

Related medicine news :

1. Indiana University researchers closer to helping hearing-impaired using stem cells
2. Boston University team finds link between high cholesterol and better cognitive performance
3. University seeks recruits for arthritis study
4. University of Manchester awarded 826k for brain science and mental health research
5. $4 million grant boosts University of Michigan campaign for a new childrens hospital
6. Lead in the environment causes violent crime, reports University of Pittsburgh researcher at AAAS
7. Next generation body scanner launched by the University of Manchester
8. University of Washington joins new Autism Treatment Network to provide better medical services
9. Binghamton University launches microelectronics research center
10. University of Manchester makes made-to-measure skin and bones a reality using inkjet printers
11. RelayHealth selected by Columbia University to link doctors and patients online

Post Your Comments:
(Date:7/28/2014)... York, NY (PRWEB) July 28, 2014 ... the body and it’s considered to be conditionally essential ... stress and is an advanced recovery & Immune System ... all the glutamine your body produces, supplementing with additional ... removal of waste products in the body, digestion and ...
(Date:7/28/2014)... Ticket Down is a dependable ... Miami, FL at the Sun Life Stadium in early September. ... Argentina and Brazil has is one that has continues to ... are forming on a consistent basis. The rivalry between ... in the recent 2014 World Cup. To the delight ...
(Date:7/28/2014)... chronic medical conditions people have at retirement age, the ... claims. Since nearly four in five older ... Bloomberg School of Public Health in Baltimore said the ... are slowing in the United States. "Living with ... heart failure is now the norm and not the ...
(Date:7/28/2014)... News) -- Endurance runners are far more likely to ... according to a new study. The researchers ... warm climates are actually 10 times more likely to ... common sudden death of a young and apparently healthy ... irregular heartbeat, often gets a lot more media attention. ...
(Date:7/28/2014)... Most cells do not divide unless there is enough ... cells and other cell types circumvent this rule. Researchers ... mechanism that overrides the cells, warning signals, enabling cancers ... supply. In the process, the researchers found that lysosomes ... cell division decisions. They also uncovered new evidence that ...
Breaking Medicine News(10 mins):Health News:Betancourt Nutrition Introduces Glutamine Plus with Sustamine® L-Alanyl-L-Glutamine 2Health News:Betancourt Nutrition Introduces Glutamine Plus with Sustamine® L-Alanyl-L-Glutamine 3Health News:Brazil vs. Colombia Tickets in Miami: Ticket Down Slashes Colombia vs. Brazil Tickets at Sun Life Stadium in Miami for Sept. 5th Showdown 2Health News:Brazil vs. Colombia Tickets in Miami: Ticket Down Slashes Colombia vs. Brazil Tickets at Sun Life Stadium in Miami for Sept. 5th Showdown 3Health News:Chronic Medical Conditions Can Shorten Seniors' Lives: Study 2Health News:Heat Stroke a Greater Threat to Endurance Runners Than Heart Problems: Study 2Health News:Cell's recycling center implicated in division decisions 2
(Date:7/28/2014)... July 28, 2014  Dignity Health St. Mary,s ... the Get With The Guidelines®-Stroke Silver-Plus Quality Achievement ... by the American Heart Association/American Stroke Association for ... number four cause of death and a leading ... United States , according to the American ...
(Date:7/28/2014)... , July 28, 2014 Reportbuyer.com has ... Global Bone Densitometers Market 2014-2018 ... bone densitometry scan is a special type of X-ray ... bone. It is used primarily to detect osteopenia or ... and the risk of fractures is high. The purpose ...
(Date:7/28/2014)... 28, 2014 Reportlinker.com announces that a ... catalogue: Portugal Pharmaceuticals and Healthcare ... http://www.reportlinker.com/p0207141/Portugal-Pharmaceuticals-and-Healthcare-Report-Q3-2014.html Includes 3 FREE ... economic growth last quarter has led us to ... As forecast previously, BMI expects Portugal,s ...
Breaking Medicine Technology:Dignity Health St. Mary's Medical Center Honored with Quality Achievement Award for Stroke Care 2Dignity Health St. Mary's Medical Center Honored with Quality Achievement Award for Stroke Care 3Global Bone Densitometers Market 2014-2018 2Global Bone Densitometers Market 2014-2018 3Global Bone Densitometers Market 2014-2018 4Global Bone Densitometers Market 2014-2018 5Portugal Pharmaceuticals and Healthcare Report Q3 2014 2Portugal Pharmaceuticals and Healthcare Report Q3 2014 3Portugal Pharmaceuticals and Healthcare Report Q3 2014 4
Cached News: