HOME >> MEDICINE >> NEWS
University of Manchester uses crystals to help battle deadly diseases

A groundbreaking technique developed at The University of Manchester, which uses crystals to map 'invisible' parts of molecules, is set to revolutionise drug discovery.

The technique, which involves sending beams of neutrons through crystals at freezing temperatures, just a few degrees above 'absolute zero', will for the first time allow scientists to see complete structures of protein molecules, right down to the last atom.

The problem faced by scientists using current methods is the fact that it is not possible to detect every atom in a protein's molecular structure, and the structures therefore are incomplete making drug design more difficult.

Professor John R. Helliwell, Professor of Structural Chemistry, who led the research, said: "This has raised the stakes in the world of drug discovery. This methodology will make research in the field more powerful, more effective and more efficient."

The breakthrough allows the molecular structures of proteins, the chemical catalysts in the body, to be studied in complete detail. In fact, experiments at the University have shown that the number of visible atoms in a molecule doubled when using the technique, compared to techniques used today.

Protein Crystallography is an important tool used to determine the three-dimensional structures of proteins. Once a pharmaceutical company has this information, it is able to tailor drugs to target specific proteins, eg interfering with the function of such proteins in infectious agents like tuberculosis - enabling the production of more effective medicines.

'Ultra-Cold Neutron Protein Crystallography' improves on current methods by probing protein structures with neutrons at temperatures of 15K (-258 degrees C), dramatically increasing the number of visible atoms. The process especially reveals the hydrogen atoms, which hold the key to many chemical reactions, and because of their low mass, are rarely revealed by current methods like
'"/>

Contact: Simon Hunter
simon.hunter-2@manchester.ac.uk
44-161-275-8387
University of Manchester
23-Nov-2004


Page: 1 2

Related medicine news :

1. Indiana University researchers closer to helping hearing-impaired using stem cells
2. Boston University team finds link between high cholesterol and better cognitive performance
3. University seeks recruits for arthritis study
4. University of Manchester awarded 826k for brain science and mental health research
5. $4 million grant boosts University of Michigan campaign for a new childrens hospital
6. Lead in the environment causes violent crime, reports University of Pittsburgh researcher at AAAS
7. Next generation body scanner launched by the University of Manchester
8. University of Washington joins new Autism Treatment Network to provide better medical services
9. Binghamton University launches microelectronics research center
10. University of Manchester makes made-to-measure skin and bones a reality using inkjet printers
11. RelayHealth selected by Columbia University to link doctors and patients online

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2016)... ... June 26, 2016 , ... Many women are confused ... endometriosis. These women need a treatment plan to not only alleviate symptoms and ... help for preservation of fertility and ultimately achieving a pregnancy. The specialists at ...
(Date:6/25/2016)... ... 2016 , ... "With 30 hand-drawn hand gesture animations, FCPX users can easily ... of Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn pictures ... . Simply select a ProHand generator and drag it above media or text in ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, Secretary of ... award to iHire in recognition of their exemplary accomplishments in worksite health promotion. , ... Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was ...
(Date:6/24/2016)... ... , ... June 19, 2016 is World Sickle Cell Observance Day. In an ... of holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued a ... Cell Disease (SCD) is a disorder of the red blood cells, which can cause ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... ... is now offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience ... Damon brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Research ... Pharma News Issue 52" report to their offering. ... in influenza treatment creates a favourable commercial environment for MedImmune ... growing patient base that will serve to drive considerable growth ... vaccine would serve to cap sales considerably, but development is ...
(Date:6/23/2016)... INDIANAPOLIS , June 23, 2016 If ... Leaders Scholarship is any indication, the future is in ... at www.diabetesscholars.org by the Diabetes Scholars Foundation ... the way of academic and community service excellence. ... since 2012, and continues to advocate for people with ...
(Date:6/23/2016)... June 23, 2016  Guerbet announced today that it ... Supplier Horizon Award . One of 12 ... recognized for its support of Premier members through exceptional ... excellence, and commitment to lower costs. ... recognition of our outstanding customer service from Premier," says ...
Breaking Medicine Technology:
Cached News: