HOME >> MEDICINE >> NEWS
University of Utah study suggests cellular waste to blame for a form of blinding eye disease

Salt Lake City - Gene mutations that impair the ability of photoreceptor cells to properly dispose of waste - and as a result cause the blinding eye disease retinitis pigmentosa - have been identified by vision researchers at the University of Utah's Moran Eye Center. The discovery raises concerns that carbonic anhydrase inhibitors (medications often used to treat both heart and eye diseases) may adversely affect vision. The study is published in the November 24, 2004 online version of the journal Human Molecular Genetics (http://hmg.oupjournals.org).

Retinitis pigmentosa (RP) is one of the most common causes of blindness. It affects one in 3,500 people or approximately two million people worldwide. Patients with RP typically are diagnosed with night blindness and, as the disease progresses, they eventually lose all of their peripheral vision and a significant portion of their central vision.

Photoreceptor cells (known as rods and cones) are located in the eye's retina and are responsible for converting light into electrical impulses for transmitting messages to the brain, according to Kang Zhang, M.D., Ph.D., the study's senior author. This process of converting light to electrical signals in the retina requires a tremendous amount of energy which, in turn, creates waste in the form of carbon dioxide and bicarbonate.

According to the paper, patients in the study each had a mutation in which a defect in the process responsible for handling carbon dioxide waste and maintaining acid and base balance led to photoreceptor degeneration.

Zhang says the mutation inhibits function of a protein complex made up of carbonic anhydrase 4 (CA4) and Na+/Bicarbonate Co-transporter1 (NBC1) from doing its job of controlling acid and base balance. "In healthy eyes this acid waste is released from the retina and into the bloodstream via tiny blood vessels called the c
'"/>

Contact: Chris Nelson
christopher.nelson@hsc.utah.edu
801-587-7693
University of Utah Health Sciences Center
24-Nov-2004


Page: 1 2

Related medicine news :

1. Indiana University researchers closer to helping hearing-impaired using stem cells
2. Boston University team finds link between high cholesterol and better cognitive performance
3. University seeks recruits for arthritis study
4. University of Manchester awarded 826k for brain science and mental health research
5. $4 million grant boosts University of Michigan campaign for a new childrens hospital
6. Lead in the environment causes violent crime, reports University of Pittsburgh researcher at AAAS
7. Next generation body scanner launched by the University of Manchester
8. University of Washington joins new Autism Treatment Network to provide better medical services
9. Binghamton University launches microelectronics research center
10. University of Manchester makes made-to-measure skin and bones a reality using inkjet printers
11. RelayHealth selected by Columbia University to link doctors and patients online

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/13/2018)... , ... December 13, 2018 , ... Researchers at the ... classes of drugs that induces the highest rate of proliferation ever observed in adult ... important step toward a diabetes treatment that restores the body’s ability to produce insulin. ...
(Date:12/13/2018)... ... December 13, 2018 , ... Mediaplanet today announces the ... campaign raises awareness regarding organ transplantation while encouraging readers to sign up as an ... currently waiting for a lifesaving organ transplant. , One organ donor can save up ...
(Date:12/13/2018)... ... December 13, 2018 , ... Individuals who are interested in entering the ... full-ride scholarship offered by Dr. Kami Hoss of Howard Healthcare Academy. , The deadline ... would enable a student to become a registered dental assistant for free in San ...
(Date:12/10/2018)... , ... December 10, 2018 , ... Loma Linda University ... major freight railyards in California and found a link with freight-railyard pollution to asthma-related ... Medicine Reports. , This large-scale railyard study is a follow-up to the ...
(Date:12/10/2018)... ... December 10, 2018 , ... Florida Hospital, soon to ... Wesley Chapel recently received the 2018 Press Ganey Guardian of Excellence Award® for ... both emergency and inpatient services is measured through random, voluntary patient surveys and ...
Breaking Medicine News(10 mins):
(Date:12/13/2018)... ... December 13, 2018 , ... Bladder issues are ... of their symptoms. Women’s Excellence now offers all bladder testing in office ... bladder testing, potassium sensitivity testing, and ultrasounds. Women’s Excellence is able to ...
(Date:12/13/2018)... ... 13, 2018 , ... Shady Grove Fertility (SGF), a nationally recognized ... states and 35 countries around the world, announced today it’s expanding its program for ... Dr. Li will see Mandarin and English-speaking patients in Rockville, MD and ...
(Date:12/13/2018)... ... 2018 , ... Sponsorship and exhibitor opportunities are available for ... the Hyatt Regency in Chicago. , The event includes more than 300 ... will be the top C-suite executives from hospitals and health systems across the ...
Breaking Medicine Technology:
Cached News: