Unpublished trials data suggest most SSRI antidepressants unsuitable for children

A UK study in this week's issue of THE LANCET suggests that reliance on published studies alone to guide the treatment of childhood depression could be inappropriate. A systematic review including published and unpublished data shows that only one drug, fluoxetine (Prozac), was not associated with negative outcomes for children with depression.

There is a clear need for effective treatment for childhood depressive disorders; up to 6% of children and adolescents are thought to suffer from depression, and suicide is the third largest cause of death among 10-19 year-olds in developed countries. The class of drugs known as selective serotonin reuptake inhibitors (SSRIs) has previously been considered to offer the best drug-treatment option for childhood depression, although recommendations for various SSRIs including fluoxetine and paroxetine (Paxil) are based on limited evidence from published studies. Questions concerning the safety of SSRIs led Craig Whittington and Tim Kendall from the National Collaborating Centre for Mental Health, London, UK, and colleagues to compare and contrast published and unpublished data on the risks and benefits of these drugs.

The investigators reanalysed data from randomised controlled trials that evaluated an SSRI compared with placebo in children aged 5-18 years that were published in a peer-reviewed journal. The analysis was extended to include data from unpublished trials (made available from the UK Committee for the Safety of Medicines).

From the published studies alone, all the SSRIs appeared to have a favourable risk-benefit ratio. With the exception of fluoxetine, the wider analysis of including data from unpublished trials suggested that the risk of SSRI treatment exceeded the benefits; for example, the inclusion of unpublished data on the effects of paroxetine showed it to be associated with a small increased risk in suicidal thoughts or attempted suicid

Contact: Joe Santangelo

Page: 1 2 3

Related medicine news :

1. Hopkins begins human trials with donor adult stem cells to repair muscle damaged from heart attack
2. US attempting to flout ethical practice for patient trials abroad
3. New trials for counseling caregivers and patients with Alzheimers begin
4. NIAID seeks applicants to lead clinical trials units for revamped HIV/AIDS networks
5. New ITN Scholars Program provides junior faculty opportunity to develop clinical trials expertise
6. OHSU researcher says FDA could broaden access to results of clinical drug trials
7. Success of experimental herpes vaccine builds momentum for human clinical trials
8. Re-analysis of large trials shows greatest benefit of chemotherapy in ER-negative tumors
9. Establishing pediatric stroke trials
10. NIAID seeks applicants to lead revamped HIV/AIDS clinical trials networks
11. Elderly cancer patients are significantly under-represented in cancer clinical trials

Post Your Comments:

(Date:9/1/2020)... ... September 01, 2020 , ... As fall and winter ... Cohn Health Institute has taken this time to expand and grow into ... 30th Anniversary, the Cohn Health Institute will be relaunching its brand new website, expanding ...
(Date:8/31/2020)... ... 31, 2020 , ... Just found out your dear friend has cancer? , It’s hard to ... family member shares their diagnosis. Once the shock wears off, the questions and fears can ... are the best ways to help? Words are failing me. I’m scared. I want to ...
(Date:8/31/2020)... ... August 31, 2020 , ... ... opportunities through high-quality, career-relevant, and affordable online education – is proud to announce ... , Among the first of its kind in the nation, the 60-credit hour ...
(Date:8/31/2020)... ... ... In an effort to give back to the community in which it serves, ... booked with a special new rate code to benefit children and families at ... Donations will be applied to any room type, any time, now through the end ...
(Date:8/28/2020)... ... 2020 , ... Ernst & Young LLP (EY US) today ... The Year® 2020 Florida Award finalist. Now in its 34th year, the Entrepreneur ... and prosperity as they build and sustain successful businesses that transform our world. ...
Breaking Medicine News(10 mins):
(Date:8/27/2020)... ... 2020 , ... The flu season is right round the corner and the risk of getting ... necessary measures before it begins to harbor its effects on us. Already with the sudden ... huge impact on our lives. Hence it has become even more relevant to keep oneself ...
(Date:8/27/2020)... (PRWEB) , ... August 27, 2020 , ... The ... conclusion of its fundraising initiative for Feeding San Diego with a press ... The GHT Companies presents the final check of $5,000.00+ representing an overall donation result ...
(Date:8/26/2020)... ... August 26, 2020 , ... ... purification systems kill Coronavirus. While air purification technologies, including GreenTech Environmental’s proprietary methods, ... even Ebola, no air purification system has published results of singular and scientific ...
Breaking Medicine Technology:
Cached News: