HOME >> MEDICINE >> NEWS
Unsuspected brain region involved in side effects of diabetes drugs

St. Louis, March 15, 2004 -- A brain region involved in emotional and intellectual processes appears to also play an unsuspected role in the body's visceral response to dangerously low blood sugar levels, according to research at Washington University School of Medicine in St Louis. Low blood sugar, called hypoglycemia, is a common and dangerous side effect of drugs that control insulin levels in people with diabetes.

The findings will be published online the week of March 15 in the Proceedings of the National Academy of Sciences. Philip E. Cryer, M.D., the Irene E. and Michael M. Karl Professor of Endocrinology and Metabolism, and William J. Powers, M.D., professor of neurology, neurological surgery and radiology, led the study.

According to Cryer, drugs that help keep blood sugar levels low often cause them to drop too far. The average person undergoing treatment for type 1 diabetes will experience symptoms of hypoglycemia about twice a week, with one episode of severe, temporarily disabling hypoglycemia per year. It also is a significant problem in people with advanced stages of type 2 diabetes.

"Hypoglycemia is the most difficult obstacle in the management of blood sugar in people with diabetes," Cryer says. "To treat diabetes you have to lower glucose levels, but we haven't figured out how to do so without the potential of triggering dangerously low levels."

The symptoms of hypoglycemia, which include shakiness, anxiety, dizziness and confusion, are all part of the body's innate response to danger. They're warning bells, letting the individual know that something is wrong that must be addressed. Curiously, symptoms are much less intense if a person has recently been hypoglycemic. This phenomenon is known as hypoglycemia unawareness.

To understand why the warning bells become muted, Cryer, Powers and their colleagues began taking brain images of healthy individuals while systematically altering participants' blood sugar
'"/>

Contact: Gila Z. Reckess
reckessg@wustl.edu
314-286-0109
Washington University School of Medicine
15-Mar-2004


Page: 1 2 3

Related medicine news :

1. Some brain cells change channels to fine-tune the message
2. First mouse model for multiple system atrophy points to new treatment targets for brain diseases
3. Can you read my mind? W.M. Keck Foundation funds innovative brain research at Carnegie Mellon
4. Scientist works on innovative treatments for brain tumors
5. Mechanism of RNA recoding: New twists in brain protein production
6. Does the college experience damage your brain?
7. Dartmouth researchers find where musical memories are stored in the brain
8. Common anesthetics appear safe for developing fetal brain
9. Breakthrough in medical research: New chemotherapy gives hope to brain tumour patients
10. New scale predicts recovery of consciousness from coma after brain injury
11. Study: Two brain systems regulate how we call for help

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2016)... ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library on June ... , brings up a new, often overlooked aspect of head lice: the parasite’s ability to ... is not a common occurrence, but a necessary one in the event that lice have ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, Dr. Omkar ... M.D from the David Geffen School of Medicine at UCLA. He trained in Internal ... complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits ... terms of the latter, setting the bar too high can result in disappointment, perhaps ... slow progress toward their goal. , Research from PsychTests.com reveals that ...
(Date:6/24/2016)... ... 24, 2016 , ... June 19, 2016 is World Sickle Cell Observance Day. ... the benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, has ... , Sickle Cell Disease (SCD) is a disorder of the red blood cells, which ...
(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg Traurig, P.A. ... The attorneys chosen by their peers for this recognition are considered among the top ... Shareholders received special honors as members of this year’s Legal Elite Hall of Fame: ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Calif. , June 23, 2016 ... CST on Thursday, July 7, 2016 , , , , ... ) , , , , EXPERT PANELISTS:  , , ... Naik; Senior Industry Analyst, Christi Bird; Senior Industry Analyst, Divyaa Ravishankar ... The global pharmaceutical industry is witnessing an exceptional ...
(Date:6/23/2016)... NORTHBROOK, Ill. and BOGOTA, Colombia , June 23, 2016  Astellas today announced the ... joins Astellas Farma Brasil as the company,s second affiliate in Latin America . ... ... appointed General Manager of Astellas Farma Colombia ... ...
(Date:6/23/2016)...  Guerbet announced today that it has been named ... . One of 12 suppliers to receive ... support of Premier members through exceptional local customer service ... to lower costs. ... outstanding customer service from Premier," says Massimo Carrara ...
Breaking Medicine Technology:
Cached News: