HOME >> MEDICINE >> NEWS
Untangling prostaglandin signaling

Prostaglanin E2 (PGE2)signaling contributes to each of the manifestations that classically define inflammationredness, heat and pain. Although non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin are well kown to inhibit this pathway by blocking prostaglandin biosynthesis, more specific agents would be useful, given the disparate biological responses that prostaglanins mediate. Stock et al. now report the genetic disruption of the PGE2 receptor EP1, one of 4 such receptors, is responsible for pain perception and the regulation of blood pressure, 2 of the cardinal physiological responses to PGE2 signaling. The authors find that pained behavior by animals treated to provoke inflammation of the gut is decreased by half in the EP1-/- strain. Remarkably, NSAID treatment causes a similar 50% diminution of such responses in wild type mice and has little or no additional benefit in mutant animals, suggesting that most of the analgesic effect of these drugs can be explained by their inhibition of signaling through this single receptor type.

Stock and colleagues also observe a drop in systolic blood pressure in male mutants, which they attribute to impaired maintenance of the extracellular fluid volume. They also note that other aspects of blood pressure regulation have been found to occur differently in males and females, both in humans and in experimental animals. Thus, although pure EP1 antagonists might prove powerful and relatively specific analgesics, such drugs might also be expected to diminish blood pressure in men.


'"/>

Contact: John Ashkenas
scied@the-jci.org
416-946-7593
Journal of Clinical Investigation
30-Jan-2001


Page: 1

Related medicine news :

1. Understanding how prostaglandin prevents gut injury during radiation therapy
2. USC researchers find evidence that progesterone signaling influences ovarian cancer risk
3. Pancreatic cancer linked to developmental cell signaling pathway

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Untangling prostaglandin signaling

(Date:11/28/2014)... 2014 PreDiabetes Centers , ... helped employees learn their risk for type 2 ... at a local school in partnership with the ... , As the Presenting Sponsor for the ... Centers is co-hosting diabetes-prevention presentations at Austin-area companies ...
(Date:11/28/2014)... CA (PRWEB) November 28, 2014 ... online, reported during the hugely popular, 2014 MTV ... antismoking organization Truth launched ground-breaking celebrity centered television ... The MTV viewership figures were estimated by ... antismoking ads placed the spotlight on celebrities photographed ...
(Date:11/28/2014)... (PRWEB) November 28, 2014 More ... have now been filed in a New Jersey ... implants, Bernstein Liebhard LLP reports. , A ... County Superior Court reflects the filing of 2,160 ... hip stems, which were voluntarily recalled on July ...
(Date:11/28/2014)... UniWigs.com, a leader in the wig industry, has announced a ... This promotion features: , > 400 pieces of ... off (no coupon code needed), > 10% off ... over $49 , Visit http://www.uniwigs.com for more details , ... Dec. 1st and the first 100 shoppers each day will receive ...
(Date:11/28/2014)... 28, 2014 Patten Pecans, based in ... With those passions driving them, they've added a pecan ... tried other pecans oils, they've found this pecan ... be exceptionally flavorful, retaining the buttery pecan notes that ... nutritional benefits found in pecans nuts is found ...
Breaking Medicine News(10 mins):Health News:PreDiabetes Centers Offers Workplace Diabetes Screening at Local School 2Health News:Freedom Laser Therapy Applauds American Legacy’s Creative Advertising Targeting Celebrity Smokers 2Health News:Freedom Laser Therapy Applauds American Legacy’s Creative Advertising Targeting Celebrity Smokers 3Health News:Freedom Laser Therapy Applauds American Legacy’s Creative Advertising Targeting Celebrity Smokers 4Health News:Freedom Laser Therapy Applauds American Legacy’s Creative Advertising Targeting Celebrity Smokers 5Health News:More than 2,100 Stryker Hip Lawsuits Included in New Jersey Litigation after Settlement Announcement, Bernstein Liebhard LLP Reports 2Health News:More than 2,100 Stryker Hip Lawsuits Included in New Jersey Litigation after Settlement Announcement, Bernstein Liebhard LLP Reports 3Health News:Pre-X'mas Crazy Sale Starts from $0 at UniWigs.com 2Health News:Patten Pecans Goes Local with Nutritious Georgia Pecan Oil 2
(Date:11/26/2014)... Nov. 26, 2014 Zynerba Pharmaceuticals , ... of innovative transdermal synthetic cannabinoid treatments, today announced that ... Annual Healthcare Conference 2014. The conference will be held ... in New York . Zynerba,s Chairman ... 4:50 pm on Tuesday, December 2. To ...
(Date:11/26/2014)... , November 25, 2014 ... Market by Power Source (Electric, Battery, Pneumatic), by ... Blade, Burr, Cart), by Application (Orthopedic, ENT, Oral, ... by MarketsandMarkets, the global Powered Surgical Instruments Market is ... Billion in 2014 and is expected to grow ...
(Date:11/26/2014)... , Nov. 25, 2014 ... focused on the development of mobile diagnostic ... testing in hospital and pre-hospital settings, today ... (ISO) 13485:2003 certification.  The certification was awarded ... of the world,s leading certification bodies. ...
Breaking Medicine Technology:Zynerba Pharmaceuticals to Present at Piper Jaffray 26th Annual Healthcare Conference 2014 2Powered Surgical Instruments Market Worth $2.1 Billion by 2019 2Powered Surgical Instruments Market Worth $2.1 Billion by 2019 3Powered Surgical Instruments Market Worth $2.1 Billion by 2019 4Nanomix Receives ISO 13485:2003 Certification 2
Cached News: