HOME >> MEDICINE >> NEWS
Untangling prostaglandin signaling

Prostaglanin E2 (PGE2)signaling contributes to each of the manifestations that classically define inflammationredness, heat and pain. Although non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin are well kown to inhibit this pathway by blocking prostaglandin biosynthesis, more specific agents would be useful, given the disparate biological responses that prostaglanins mediate. Stock et al. now report the genetic disruption of the PGE2 receptor EP1, one of 4 such receptors, is responsible for pain perception and the regulation of blood pressure, 2 of the cardinal physiological responses to PGE2 signaling. The authors find that pained behavior by animals treated to provoke inflammation of the gut is decreased by half in the EP1-/- strain. Remarkably, NSAID treatment causes a similar 50% diminution of such responses in wild type mice and has little or no additional benefit in mutant animals, suggesting that most of the analgesic effect of these drugs can be explained by their inhibition of signaling through this single receptor type.

Stock and colleagues also observe a drop in systolic blood pressure in male mutants, which they attribute to impaired maintenance of the extracellular fluid volume. They also note that other aspects of blood pressure regulation have been found to occur differently in males and females, both in humans and in experimental animals. Thus, although pure EP1 antagonists might prove powerful and relatively specific analgesics, such drugs might also be expected to diminish blood pressure in men.


'"/>

Contact: John Ashkenas
scied@the-jci.org
416-946-7593
Journal of Clinical Investigation
30-Jan-2001


Page: 1

Related medicine news :

1. Understanding how prostaglandin prevents gut injury during radiation therapy
2. USC researchers find evidence that progesterone signaling influences ovarian cancer risk
3. Pancreatic cancer linked to developmental cell signaling pathway

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Untangling prostaglandin signaling

(Date:8/28/2015)... ... August 28, 2015 , ... Popular review site Top5MillionaireDatingSites.com ... dating sites . According to the listings, MillionaireMatch.com bags the top ... , A spokesperson of Top5MillionaireDatingSites.com said, “This website has been designed ...
(Date:8/28/2015)... TN (PRWEB) , ... August 28, 2015 , ... A ... the Centers for Medicare & Medicaid Services’ (CMS) proposal to mandate bundled payments ... webinar , “Get Ready for Game Day: Comprehensive Care for Joint Replacement,” takes ...
(Date:8/28/2015)... ... 2015 , ... Where can successful, well educated, or attractive ... up to help quality singles find dating partners or ideal matches. , ... well educated, or attractive. , It updates profiles under the category of " ...
(Date:8/27/2015)... ... 28, 2015 , ... Shortening the school week to four ... according to researchers at Georgia State University and Montana State University. , The ... impact of a four-day school week on student achievement by comparing fourth-grade reading ...
(Date:8/27/2015)... (PRWEB) , ... August 27, 2015 , ... Keck Graduate ... Seventy-seven students received their White Coats at a formal ceremony recognizing them as members ... the pharmacy profession on Saturday, August 22. Symbolizing dedication to clinical service and patient ...
Breaking Medicine News(10 mins):Health News:Top5MillionaireDatingSites.com Publishes Its First List of Reviews of the Best Millionaire Dating Sites 2Health News:PYA Offers Complimentary CCJR Webina — Game On 2Health News:PYA Offers Complimentary CCJR Webina — Game On 3Health News:MillionaireMatchmakerOnline.net Collects and Updates Newest Millionaire and Quality Single Profiles on the Page of Millionaire Matchmaker Online Canada. 2Health News:MillionaireMatchmakerOnline.net Collects and Updates Newest Millionaire and Quality Single Profiles on the Page of Millionaire Matchmaker Online Canada. 3Health News:Four-Day School Week Can Improve Academic Performance, Study Finds 2Health News:Four-Day School Week Can Improve Academic Performance, Study Finds 3Health News:KGI School of Pharmacy’s 2nd Annual White Coat Ceremony a Success 2Health News:KGI School of Pharmacy’s 2nd Annual White Coat Ceremony a Success 3Health News:KGI School of Pharmacy’s 2nd Annual White Coat Ceremony a Success 4
(Date:8/28/2015)... , August 28, 2015 The scientific ... collaboration with one of the leading academics in the field ... world record holder in life extension for model animals - ... biology of aging and age-related diseases, primarily, around the stability ... has just been published as "Stability analysis of a model ...
(Date:8/28/2015)... PITTSBURGH , Aug. 28, 2015 /PRNewswire/ ... that its shareholders have approved Mylan,s proposed acquisition ... TASE) and the related issuance of Mylan ordinary ... meeting of shareholders held today. The transaction received ... extraordinary general meeting. In addition, the transaction received ...
(Date:8/28/2015)... The global mHealth market ... by 2020, growing at a CAGR of 47.6% from ... Grand View Research, Inc. Monitoring services is expected to ... to 2020.      (Logo: http://photos.prnewswire.com/prnh/20150105/723757 ) ... incidences of chronic diseases such as cancer, heart ailments, ...
Breaking Medicine Technology:Gero: Physics Meets Biology to Help Defeat Aging 2Gero: Physics Meets Biology to Help Defeat Aging 3Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 2Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 3Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 4Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 5Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 6Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 7Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 8Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 9mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 2mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 3mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 4mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 5
Cached News: