HOME >> MEDICINE >> NEWS
Urine protein test: A tipoff to kidney transplant rejection

Johns Hopkins researchers have developed the basis of an inexpensive, simple urine test that identifies impending kidney failure or rejection following transplant surgery. Their work, presented this week in a special invited lecture to the American Transplant Congress in Boston, Mass., is based on proteins found in urine, and could lead to a urine test kit that may allow many patients to skip painful biopsies.

"This has the potential to radically change the way transplant patients are managed," says study co-author Ernesto P. Molmenti, M.D., Ph.D., associate professor of surgery at Johns Hopkins. "Frequent, noninvasive monitoring could allow doctors to better tailor immunosuppression drugs according to individual patient's needs, prescribing lower doses to more stable patients or increasing doses for patients who show early signs of rejection."

Molmenti estimates that the test, when developed, will be far less expensive, safer and much less painful than a standard biopsy costing hundreds of dollars in which a doctor inserts a long needle into a patient's side to obtain a kidney tissue sample.

To build a scientific foundation for the test, Molmenti and colleagues analyzed 34 urine samples from 32 kidney patients at various stages after transplantation. Seventeen patients had organ rejection and 15 had no rejection. Rejection status was confirmed by biopsy. The researchers identified thirteen possible protein markers that were present in most of the urine samples from patients who had organ rejection, but were absent from most non-rejection samples. Three other possible protein markers were found to be lower in patients' urine with the onset of transplant rejection. A separate analysis using a combination of biomarker candidates in a panel correctly identified 91% of the 34 urine samples.

"Unlike kidney biopsy, a urine test is risk-free, presents no discomfort or restraints to the patients, and samples the entire kidney accura
'"/>

Contact: Trent Stockton
tstockt1@jhmi.edu
410-955-8665
Johns Hopkins Medical Institutions
18-May-2004


Page: 1 2

Related medicine news :

1. Urine test predicts Alzheimers disease
2. Targeting mutant B-Raf protein reduces melanoma development
3. Mechanism of RNA recoding: New twists in brain protein production
4. Epstein-Barr virus protein crucial to its role in blood cancers
5. Neuronal death and processing of Tau protein in Alzheimers disease
6. CK2 protein sustains colon cancer cells by sabotaging ability to commit suicide
7. Brain synapse formation linked to proteins, Stanford study finds
8. Stat5 protein inhibits spread of breast cancer cells
9. UCSD-Salk team show proteins gene-silencing role in development of nervous system
10. Controversial drug shown to act on brain protein to cut alcohol use
11. New protein discovered by Hebrew University researchers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/21/2020)... ... February 21, 2020 , ... Dr. Stong, a leading Atlanta ... giving back. He has been a long-time volunteer with Healing the Children (HTC) ... particular HTC trip is to provide cleft lip and palate procedures to underprivileged pediatric ...
(Date:2/21/2020)... ... 21, 2020 , ... Used for years as a natural ... as a viable replacement for invasive cosmetic surgery, such as breast augmentation. According ... the market leader for the expected robust growth of autologous fat grafting procedures. ...
(Date:2/21/2020)... ... 2020 , ... Isagenix International , a global health ... final round of Canada finalists for its annual total-body transformation program, the ... Taiya Farrell of Winnipeg, Manitoba; Véronique Collin of Orleans, Ontario; and James Pearce ...
(Date:2/20/2020)... ... February 20, 2020 , ... Millennial women are flocking to cosmetic surgeons ... Milford, Penn requesting treatments to achieve “ Rich Girl Face .” In fact, Glamour ... is slowing down into 2020. It’s a look inspired by the signature bee-stung lips, ...
(Date:2/19/2020)... ... February 19, 2020 , ... ... Periodontics and Dental Implant Center of Connecticut, celebrate 30 years of serving Monroe, ... the same low fees that they charged in 1989, only thirty dollars. To ...
Breaking Medicine News(10 mins):
(Date:2/23/2020)... ... 2020 , ... The University of Minnesota’s Integrated Food Systems Leadership Program ... Crisis ’ in Food Safety Magazine's February/March issue. The publication’s cover story, ... into the boundaries that food system leaders need to break in order to address ...
(Date:2/21/2020)... ... ... The business of healthcare management is complex. From providing the best care to ... and physical safety, there are many things to keep up with. Very often, building ... to provide their insights on healthcare facility maintenance to attendees at the North ...
(Date:2/20/2020)... ... 20, 2020 , ... PAINWeekEnd on March 21 and 22 ... a timely and relevant 2-day program providing busy clinicians and allied healthcare practitioners ... , In 2020, paper prescriptions for certain painkillers have been banned in Arizona. ...
Breaking Medicine Technology:
Cached News: