HOME >> MEDICINE >> NEWS
Use it or lose it applies to nervous system, scientists find

St. Louis, Oct. 15, 1999 - For the first time, scientists have monitored the comings and goings of a membrane protein in living animals. They found that a muscle protein that receives messages from nerve fibers skulks away if ignored. This may explain why withdrawal of neuromuscular blocking agents sometimes is fatal to patients who have been on respirators. And it supports the idea that learning involves rapid molecular changes at cellular junctions in the brain.

"Our study shows that activity in the nervous system has a surprisingly rapid effect on the structure of synapses" the structures where nerve cells communicate with their targets," says Jeff W. Lichtman, M.D., Ph.D., head of the research team.

Lichtman is a professor of neurobiology at Washington University School of Medicine in St. Louis. He and his colleagues report their findings in the Oct. 15 issue of Science. Postdoctoral fellow Mohammed Akaaboune, Ph.D., is first author of the paper, which is accompanied by a commentary from Miriam M. Salpeter, Ph.D., of Cornell University.

Neuromuscular synapses connect nerve terminals to muscle fibers. When the nerve terminal releases a chemical signal called acetylcholine, protein molecules on the muscle fiber's surface bind the acetylcholine and initiate a chain of events that lead to muscle contraction. These protein molecules, called acetylcholine receptors, huddle under the nerve terminal so they are in the best place to receive the chemical signal.

For many years, Lichtman's group has used a fluorescent form of bungarotoxin to light up acetylcholine receptors in living animals. This constituent of snake venom permanently combines with the receptors, putting muscles out of action. In 1996, a researcher in Lichtman's lab, Stephen G. Turney, figured out how to use this labeling technique to measure the amount of acetylcholine receptor protein at individual synapses.

In the current study, the researchers determined how receptor con
'"/>

Contact: Linda Sage
sage@medicine.wustl.edu
314-286-0119
Washington University School of Medicine
14-Oct-1999


Page: 1 2 3 4

Related medicine news :

1. UCSD-Salk team show proteins gene-silencing role in development of nervous system
2. High societal cost of brain and nervous system disorders attributed to genetic influences
3. Exposure to atomic bomb radiation associated with nervous system tumors
4. Researchers identify for the first time proteins vital to maintaining nervous system architecture
5. UCSD and Japanese researchers identify new gene involved in development and function of central nervous system
6. Mayo Clinic scientists discover way to enhance immune system that repairs nervous system in mouse model
7. Cocaine acts on central nervous system, causing vessel constriction, rapid heartbeat
8. New protocol to develop compound to treat disorders of the central nervous system is more efficient
9. Nursing homes not burden to system, says researcher
10. Red wine can help maintain immune system, UF researcher finds
11. OHSU scientists test medication to treat involuntary weight loss

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Use lose applies nervous system scientists find

(Date:10/22/2014)... OR (PRWEB) October 22, 2014 During ... California’s fresh water supply runs dangerously low, Southern Oregon’s ... Southern Oregon’s rivers, despite the lowest mountain snow pack ... in late summer and early autumn.* That was the ... of the new book “Hiking Southern Oregon,” during an ...
(Date:10/22/2014)... Texas (PRWEB) October 22, 2014 ... of completing their continuing education at home or ... have access to 20 brand new, premium Seminar-on-Demand ... robust catalog of over 2,000 hours ... fully customize their educational experience. With such a ...
(Date:10/22/2014)... there are only 24 hours in a day, that doesn’t seem ... time within their busy schedules for exercise and fitness. Fortunately, one ... get in shape. Here are five ways you can reach your ... Up Your Commute , Consider riding a bike or taking the ... daily routine. If you must use your car to get to ...
(Date:10/22/2014)... 22, 2014 Richard Carlson, Managing Partner ... leader with over 25 years experience. Mr. Carlson ... the areas related to EDI, B2B Commerce, RFID and ... Editorial Advisory Board member for Pharmaceutical Commerce Magazine and ... Fin Group is a management and technology consulting firm ...
(Date:10/22/2014)... Reinberg HealthDay Reporter , TUESDAY, ... weight and length may be showing a genetic propensity for ... certain genes have been linked to increased body fat, but ... and lean muscle, the researchers said. At 1 year, ... ages 2 and 3, however, these genes were linked to ...
Breaking Medicine News(10 mins):Health News:Southern Oregon Is West’s Most Drought Proof Fresh Water Region Say Hiking Guide Authors 2Health News:Southern Oregon Is West’s Most Drought Proof Fresh Water Region Say Hiking Guide Authors 3Health News:Southern Oregon Is West’s Most Drought Proof Fresh Water Region Say Hiking Guide Authors 4Health News:Top Provider of Continuing Education at Home Releases 20 New Online Courses 2Health News:HealthGuideMD Presents Ways to Improve Your Exercise and Fitness 2Health News:Rich Carlson and Marc Duey to Hold Workshop at CBI’s Specialty Pharmacy and Distribution Networks Conference 2Health News:Tall, Heavy 1-Year-Olds May Be at Risk for Obesity Later, Study Finds 2
(Date:10/22/2014)... Oramed Pharmaceuticals Inc. (NASDAQCM: ... company focused on the development of oral drug ... from its Phase IIa clinical trial of ORMD-0801, ... type 1 diabetes. The trial was conducted in ... U.S. Food and Drug Administration (FDA) Investigational New ...
(Date:10/22/2014)... -- Influenza will affect as many as 200,000 people this ... States as high as 49,000 people.  The main ... person to person in respiratory droplets of coughs and sneezes. ... but kills much fewer people each year than the Flu. ... including sweat, saliva, blood and other bodily fluids. The Ebola ...
(Date:10/22/2014)... MOUNTAIN VIEW, Calif. , Oct. 22, ... 11:00 a.m. EDTLOCATION: Online, complimentary registration available ... Group Team Leader Archana Vidyasekar and Visionary ... VargheseBrain-controlled computers, WiFi-like wireless electricity, self-assembling materials, ... top ten technologies which will transform our ...
Breaking Medicine Technology:Oramed Pharmaceuticals Reports Positive Top-Line Data from U.S. Phase IIa Trial with Oral Insulin in Type 1 Diabetes 2Oramed Pharmaceuticals Reports Positive Top-Line Data from U.S. Phase IIa Trial with Oral Insulin in Type 1 Diabetes 3Oramed Pharmaceuticals Reports Positive Top-Line Data from U.S. Phase IIa Trial with Oral Insulin in Type 1 Diabetes 4WholeHealth Products is proud to be releasing its Influenza A and B combo test, on the heels of the announcing of its phase 2 completion of the Rapid Ebola Test 2Futuristic Technologies That Will Transform Our World Beyond 2030 2Futuristic Technologies That Will Transform Our World Beyond 2030 3Futuristic Technologies That Will Transform Our World Beyond 2030 4
Cached News: