HOME >> MEDICINE >> NEWS
Use it or lose it applies to nervous system, scientists find

St. Louis, Oct. 15, 1999 - For the first time, scientists have monitored the comings and goings of a membrane protein in living animals. They found that a muscle protein that receives messages from nerve fibers skulks away if ignored. This may explain why withdrawal of neuromuscular blocking agents sometimes is fatal to patients who have been on respirators. And it supports the idea that learning involves rapid molecular changes at cellular junctions in the brain.

"Our study shows that activity in the nervous system has a surprisingly rapid effect on the structure of synapses" the structures where nerve cells communicate with their targets," says Jeff W. Lichtman, M.D., Ph.D., head of the research team.

Lichtman is a professor of neurobiology at Washington University School of Medicine in St. Louis. He and his colleagues report their findings in the Oct. 15 issue of Science. Postdoctoral fellow Mohammed Akaaboune, Ph.D., is first author of the paper, which is accompanied by a commentary from Miriam M. Salpeter, Ph.D., of Cornell University.

Neuromuscular synapses connect nerve terminals to muscle fibers. When the nerve terminal releases a chemical signal called acetylcholine, protein molecules on the muscle fiber's surface bind the acetylcholine and initiate a chain of events that lead to muscle contraction. These protein molecules, called acetylcholine receptors, huddle under the nerve terminal so they are in the best place to receive the chemical signal.

For many years, Lichtman's group has used a fluorescent form of bungarotoxin to light up acetylcholine receptors in living animals. This constituent of snake venom permanently combines with the receptors, putting muscles out of action. In 1996, a researcher in Lichtman's lab, Stephen G. Turney, figured out how to use this labeling technique to measure the amount of acetylcholine receptor protein at individual synapses.

In the current study, the researchers determined how receptor con
'"/>

Contact: Linda Sage
sage@medicine.wustl.edu
314-286-0119
Washington University School of Medicine
14-Oct-1999


Page: 1 2 3 4

Related medicine news :

1. UCSD-Salk team show proteins gene-silencing role in development of nervous system
2. High societal cost of brain and nervous system disorders attributed to genetic influences
3. Exposure to atomic bomb radiation associated with nervous system tumors
4. Researchers identify for the first time proteins vital to maintaining nervous system architecture
5. UCSD and Japanese researchers identify new gene involved in development and function of central nervous system
6. Mayo Clinic scientists discover way to enhance immune system that repairs nervous system in mouse model
7. Cocaine acts on central nervous system, causing vessel constriction, rapid heartbeat
8. New protocol to develop compound to treat disorders of the central nervous system is more efficient
9. Nursing homes not burden to system, says researcher
10. Red wine can help maintain immune system, UF researcher finds
11. OHSU scientists test medication to treat involuntary weight loss

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Use lose applies nervous system scientists find

(Date:7/3/2015)... Greenville, SC (PRWEB) , ... ... ... Society has announced the sessions and speaker lineup for its 2015 ... nursing, taking place August 6-8, 2015 at the Renaissance Orlando at SeaWorld ...
(Date:7/3/2015)... ... July 03, 2015 , ... The Erie County Bar ... at 1:00pm. The Association welcomed speaker C. Daniel McGillicuddy Esq. of William Mattar ... points of investigating these types of cases. , Each year, New York State ...
(Date:7/3/2015)... ... July 03, 2015 , ... " Selfie on a Stick ” was ... and coolest technology products available to consumers. Amanda Forstrom, a technology expert and special ... are great for documenting memories. , Almost every smartphone has an incredibly powerful camera ...
(Date:7/2/2015)... ... ... sweetFrog Enterprises, LLC. is pleased to announce the opening of its newest location in Dallas, ... The premium frozen yogurt chain was listed as #22 on the Inc. 500 list of ... at Bachman Lake, is located at:, 3701 W. Northwest Highway, STE 430, Dallas, TX 75220 ...
(Date:7/2/2015)... Lincoln, RI (PRWEB) , ... July 02, 2015 , ... ... keep safety in mind. That’s why Amica Insurance is sharing some tips ... Safety Commission (CPSC), approximately 230 people go to the emergency room daily with fireworks-related ...
Breaking Medicine News(10 mins):Health News:RNS Announces Sessions and Speaker Lineup for the 2015 Annual Conference of the Rheumatology Nurses Society 2Health News:RNS Announces Sessions and Speaker Lineup for the 2015 Annual Conference of the Rheumatology Nurses Society 3Health News:Attorney from William Mattar Leads Discussion on Bicycle Accidents 2Health News:Learn How to Take Selfies like Kendall Jenner 2Health News:sweetFrog Opens 18th Location in the Lone Star State 2Health News:6 Fireworks Safety Tips from Amica Insurance 2
(Date:7/2/2015)... South Korea, July 2, 2015 ALPINION MEDICAL SYSTEMS ... E-CUBE Series ultrasound system. Developed to enhance user experience ... the E-CUBE 15 EX produces superb image quality. With ... in women,s health, general imaging, and shared service applications. ... latest in the renowned E-CUBE Series, the E-CUBE 15 ...
(Date:7/2/2015)... -- Research and Markets( http://www.researchandmarkets.com/research/9q4d5d/veterinary_ ) ... Animal Vaccines Market by Product, Diseases & Technology - ... The global animal vaccines market is poised ... in 2015, at a CAGR of 5.5% from 2015 ... are growing prevalence of animal diseases, increasing incidences of ...
(Date:7/2/2015)... Legal-Bay LLC, The Lawsuit Settlement Funding Company, announced today ... the Southern District of West Virginia ... for a single trial to take place on November ... include claims from the women plaintiffs that they were ... Ethicon subsidiary. The cases against Ethicon are among approximately ...
Breaking Medicine Technology:E-CUBE 15 EX from ALPINION Enhances User Experience and Patient Care 2E-CUBE 15 EX from ALPINION Enhances User Experience and Patient Care 3Veterinary / Animal Vaccines Market 2015 - Global Forecast to 2020 for the $7.19 Billion Industry 2Judge Sets Single Trial for 26 Ethicon Mesh Cases, says Legal-Bay Lawsuit Settlement Funding 2Judge Sets Single Trial for 26 Ethicon Mesh Cases, says Legal-Bay Lawsuit Settlement Funding 3
Cached News: