HOME >> MEDICINE >> NEWS
Use it or lose it applies to nervous system, scientists find

St. Louis, Oct. 15, 1999 - For the first time, scientists have monitored the comings and goings of a membrane protein in living animals. They found that a muscle protein that receives messages from nerve fibers skulks away if ignored. This may explain why withdrawal of neuromuscular blocking agents sometimes is fatal to patients who have been on respirators. And it supports the idea that learning involves rapid molecular changes at cellular junctions in the brain.

"Our study shows that activity in the nervous system has a surprisingly rapid effect on the structure of synapses" the structures where nerve cells communicate with their targets," says Jeff W. Lichtman, M.D., Ph.D., head of the research team.

Lichtman is a professor of neurobiology at Washington University School of Medicine in St. Louis. He and his colleagues report their findings in the Oct. 15 issue of Science. Postdoctoral fellow Mohammed Akaaboune, Ph.D., is first author of the paper, which is accompanied by a commentary from Miriam M. Salpeter, Ph.D., of Cornell University.

Neuromuscular synapses connect nerve terminals to muscle fibers. When the nerve terminal releases a chemical signal called acetylcholine, protein molecules on the muscle fiber's surface bind the acetylcholine and initiate a chain of events that lead to muscle contraction. These protein molecules, called acetylcholine receptors, huddle under the nerve terminal so they are in the best place to receive the chemical signal.

For many years, Lichtman's group has used a fluorescent form of bungarotoxin to light up acetylcholine receptors in living animals. This constituent of snake venom permanently combines with the receptors, putting muscles out of action. In 1996, a researcher in Lichtman's lab, Stephen G. Turney, figured out how to use this labeling technique to measure the amount of acetylcholine receptor protein at individual synapses.

In the current study, the researchers determined how receptor con
'"/>

Contact: Linda Sage
sage@medicine.wustl.edu
314-286-0119
Washington University School of Medicine
14-Oct-1999


Page: 1 2 3 4

Related medicine news :

1. UCSD-Salk team show proteins gene-silencing role in development of nervous system
2. High societal cost of brain and nervous system disorders attributed to genetic influences
3. Exposure to atomic bomb radiation associated with nervous system tumors
4. Researchers identify for the first time proteins vital to maintaining nervous system architecture
5. UCSD and Japanese researchers identify new gene involved in development and function of central nervous system
6. Mayo Clinic scientists discover way to enhance immune system that repairs nervous system in mouse model
7. Cocaine acts on central nervous system, causing vessel constriction, rapid heartbeat
8. New protocol to develop compound to treat disorders of the central nervous system is more efficient
9. Nursing homes not burden to system, says researcher
10. Red wine can help maintain immune system, UF researcher finds
11. OHSU scientists test medication to treat involuntary weight loss

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Use lose applies nervous system scientists find

(Date:9/1/2015)... ... September 01, 2015 , ... Philanthropic giving in the U.S. ... issues and needs. Money for Good 2015, released today by Camber Collective, goes to ... annual potential to mobilize up to $22B in new philanthropic giving and shift $25B ...
(Date:9/1/2015)... ... September 01, 2015 , ... As part of its ... Shield of Minnesota (Blue Cross) has announced Doctor On Demand as the company’s ... Doctor On Demand provides immediate access to Board Certified physicians or next-day appointments ...
(Date:9/1/2015)... (PRWEB) , ... September 01, 2015 , ... ... Cleveland Clinic, ranked a top-five hospital by U.S. News & World Report, to ... cancer patients. , Editorial and marketing groups within OncLive, which provides oncologists ...
(Date:9/1/2015)... (PRWEB) , ... September 01, 2015 , ... ... law firms and government entities, announced today that it has hired Scott Sanderson, ... Consultant. In this capacity, Sanderson will be responsible for establishing and managing ...
(Date:9/1/2015)... ... , ... The FSH Society , the Massachusetts-based charity that has transformed ... the beneficiary of a collection of fundraising events this fall. From Boston to Los ... Society and further FSHD research. , The list of 2015 fall events ...
Breaking Medicine News(10 mins):Health News:Camber Collective Releases Money for Good 2015 - Revealing Root Causes to Why Charitable Giving Has Been Stuck at 2% GDP Since the 70s 2Health News:Camber Collective Releases Money for Good 2015 - Revealing Root Causes to Why Charitable Giving Has Been Stuck at 2% GDP Since the 70s 3Health News:Blue Cross and Blue Shield of Minnesota names Doctor On Demand as preferred telehealth destination 2Health News:Blue Cross and Blue Shield of Minnesota names Doctor On Demand as preferred telehealth destination 3Health News:OncLive® and Cleveland Clinic Team up to Provide News, Information About Cancer Research and Patient Care 2Health News:OncLive® and Cleveland Clinic Team up to Provide News, Information About Cancer Research and Patient Care 3Health News:Former NFL Standout Scott Sanderson Joins eDiscovery Leader Discovia 2Health News:FSH Society Beneficiary of Variety of Fall Fundraising Events 2Health News:FSH Society Beneficiary of Variety of Fall Fundraising Events 3
(Date:9/1/2015)... September 1, 2015 The ... the basis of sectors, products & services and ... coupled with the increasing demand of advanced drugs ... to propel the growth for bioinformatics market. The ... efficiently is known as bioinformatics. Decreasing cost of ...
(Date:9/1/2015)... Research and Markets ( http://www.researchandmarkets.com/research/r8v22b/regulatory ) has announced the ... (London, UK - September 24-25, 2015)" conference to ... provides an introduction to Pharmaceutical Regulatory Affairs and the ... for those working in a support staff role. ... regulatory procedures required to register products in ...
(Date:9/1/2015)... , September 1, 2015 - ... GARFIELD-AF R egistry data presented ... insights on the evolution of manag ... -   The first-ever two-year outcomes ... at ESC Congress 2015 expose that all-cause death was the most frequent major ...
Breaking Medicine Technology:Global Bioinformatics Market Valued at Over $1.3 Billion in 2013 and is Expected to Grow at CAGR of 20.3% From 2014 to 2020: Hexa Research 2Global Bioinformatics Market Valued at Over $1.3 Billion in 2013 and is Expected to Grow at CAGR of 20.3% From 2014 to 2020: Hexa Research 3Global Bioinformatics Market Valued at Over $1.3 Billion in 2013 and is Expected to Grow at CAGR of 20.3% From 2014 to 2020: Hexa Research 4Regulatory Affairs for Support Staff Seminar (London, UK - September 24-25, 2015) 2Global Atrial Fibrillation Registry Presents Two-Year Outcomes Data In More Than 17,000 Newly Diagnosed AF Patients 2Global Atrial Fibrillation Registry Presents Two-Year Outcomes Data In More Than 17,000 Newly Diagnosed AF Patients 3Global Atrial Fibrillation Registry Presents Two-Year Outcomes Data In More Than 17,000 Newly Diagnosed AF Patients 4Global Atrial Fibrillation Registry Presents Two-Year Outcomes Data In More Than 17,000 Newly Diagnosed AF Patients 5Global Atrial Fibrillation Registry Presents Two-Year Outcomes Data In More Than 17,000 Newly Diagnosed AF Patients 6Global Atrial Fibrillation Registry Presents Two-Year Outcomes Data In More Than 17,000 Newly Diagnosed AF Patients 7Global Atrial Fibrillation Registry Presents Two-Year Outcomes Data In More Than 17,000 Newly Diagnosed AF Patients 8Global Atrial Fibrillation Registry Presents Two-Year Outcomes Data In More Than 17,000 Newly Diagnosed AF Patients 9
Cached News: