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Using vitamin E and C supplements together may reduce risk of Alzheimer disease

CHICAGO Elderly persons who take individual vitamin E and C supplements together may reduce their risk of Alzheimer disease (AD), according to an article in the January issue of The Archives of Neurology, one of the JAMA/Archives journals.

According to the article, the public health threat of AD will continue to grow as people live longer. Previous studies have shown that antioxidant vitamins may protect the brain against damage caused by free radicals and other reactive oxygen species molecular byproducts of basic cellular metabolism. Neurons are especially sensitive to damage caused by free radicals, which is believed to be partially responsible for the development of AD. Incorporating antioxidants (which help to neutralize these free radicals) into the diet through food or supplementation may help protect neurons.

Peter P. Zandi, Ph.D., of The Johns Hopkins University Bloomberg School of Public Health, Baltimore, and colleagues examined the relationship between antioxidant supplement use and risk of AD.

The researchers assessed the prevalence of dementia and AD in 4,740 elderly (65 years or older) residents of Cache County, Utah in 1995 to 1997 and collected information about supplement use. These residents were followed-up in 1998 to 2000 for new cases of dementia or AD. The researchers identified 200 cases of AD (prevalent cases) between 1995 and 1997, and 104 new cases (incident cases) of AD during follow-up.

The researchers categorized participants as vitamin E users if they reported taking an individual supplement of vitamin E or a multivitamin containing more than 400 IU (international units) of vitamin E. Vitamin C users reported taking vitamin C supplements or multivitamins containing at least 500 micrograms of ascorbic acid. Individuals were classified as multivitamin users if they reported taking multivitamins containing lower doses of vitamin E or C.

The researchers found the greatest reductio
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Contact: Kenna Brigham
410-955-6878
JAMA and Archives Journals
19-Jan-2004


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