HOME >> MEDICINE >> NEWS
VA trial to weigh aspirin against other anti-clotting drugs in heart disease patients

For decades doctors have prescribed two drugs, aspirin and warfarin, to heart disease patients to help prevent blood clots, and although both drugs are effective they have never been compared in a large clinical trial. An international study begun recently by researchers at the San Francisco Veterans Affairs Medical Center (SFVAMC) will match these two old drugs against each other, and against a newer drug called clopidogrel, to see which of them prevents more heart attacks, strokes, and deaths in patients with chronic heart failure.

Unlike most international clinical trials in recent years, the 4,500-patient study will not be predominantly funded by a pharmaceutical or biotech company, said the study's chairman Barry Massie, MD, UCSF professor of medicine, and chief of the cardiology division at the SFVAMC. All three drugs in the trial already are approved for patients with heart disease and several other conditions. But the VA, which is paying about half of the trial's cost through its cooperative study program, recognized that determining which drug is most effective could save patient lives and might also reduce costs.

"The results of this study have the potential to greatly affect practice," Massie said. "For instance, between 20 and 40 percent of heart failure patients now receive warfarin. That figure will either increase or decrease substantially depending on the results. Aspirin is widely used in patients with coronary heart disease, the leading cause of heart failure. However, there is some evidence that aspirin may have negative effects in heart failure patients under some circumstances. If this proves to be so, many of these patients will be switched to warfarin or clopidogrel."

When the study is completed, Massie said, doctors will be able to choose among the three medicines based on three important factors: efficacy, safety and cost.

One of the most interesting and important questions the trial will address is whether a
'"/>

Contact: Kevin Boyd
kboyd@pubaff.ucsf.ed
415-476-2557
University of California - San Francisco
10-Dec-2000


Page: 1 2 3

Related medicine news :

1. Lack of clinical trial participation may contribute to lower survival rates
2. Protecting children from industrial chemicals in the environment
3. Hopkins begins human trials with donor adult stem cells to repair muscle damaged from heart attack
4. US attempting to flout ethical practice for patient trials abroad
5. NIAID initiates trial of experimental avian flu vaccine
6. African-American women with endometrial cancer have more aggressive cancer than Caucasian women
7. WISE study starts in Toulouse: 60 days of bed-rest for terrestrial female astronauts
8. Sharing clinical trial results with participants may be beneficial
9. Emergency clopidogrel could save thousands of lives46,000-patient heart attack trial results
10. New trials for counseling caregivers and patients with Alzheimers begin
11. EuroVacc 02 HIV vaccine trial begins in February 2005

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/19/2020)... Ga. (PRWEB) , ... February 19, 2020 , ... ... announce they are holding a CoolEvent for FDA-cleared CoolSculpting®, the world’s most popular ... 6345 Halcyon Way, Suite 850 in the Halcyon Village Center in Alpharetta, Georgia. ...
(Date:2/16/2020)... , ... February 16, 2020 , ... Canadian digital healthcare ... the world to call who are concerned about the Coronavirus. , "It is our ... are trying to contain this deadly virus" said Prakash Chand, CEO of Ask The ...
(Date:2/15/2020)... ... , ... Sister companies, Special Learning Inc. and ABA Business Growth, are offering ... explores the challenges, risks, and opportunities of private equity investment and acquisition in the ... https://bit.ly/2OU6lxg , Since 2010, more than 60 private equity firms have ...
(Date:2/14/2020)... ... 14, 2020 , ... ScripHessco has announced the release of ... breaks down the benefits of chiropractic care during pregnancy and how to find ... quite beneficial to the mother’s health. Seeing a chiropractor during pregnancy leads to ...
(Date:2/14/2020)... ... February 14, 2020 , ... Cloudticity announced today ... the company’s support for healthcare organizations using Amazon Web Services (AWS). , “Our ... or experience to do so,” explained Cloudticity Founder & CEO, Gerry Miller. “In ...
Breaking Medicine News(10 mins):
(Date:2/20/2020)... ... ... NJ Top Docs practice, The Rubino OB/GYN Group hosted a ribbon-cutting ceremony ... 16 at 12PM. The Rubino OB/GYN Group founder, Dr. Robert Rubino, was joined ... public and media were also in attendance. , The office space at 27 Mountain ...
(Date:2/20/2020)... , ... February 20, 2020 , ... ... 6333 North Scottsdale Road, in Arizona, will be a timely and relevant 2-day ... practical instruction in the management of chronic pain. , In 2020, paper prescriptions ...
(Date:2/19/2020)... ... February 19, 2020 , ... Today, Georgetown Home ... rehospitalization rate are the lowest in the company’s history. , Georgetown Home ... year over year. GHC’s skilled nursing facility (SNF) rehospitalization rate was 0 percent ...
Breaking Medicine Technology:
Cached News: