HOME >> MEDICINE >> NEWS
VGTI researchers help uncover why aging reduces immune system function

PORTLAND, Ore. Scientists at the Vaccine and Gene Therapy Institute at Oregon Health & Science University have made a discovery that helps explain why our immune system worsens with age. The work was led by Janko Nikolich-Zugich, M.D., Ph.D., a senior scientist at the VGTI. The scientists hope this new information can be used to better protect the elderly from infectious diseases by finding ways to slow or stop the degradation of the immune system. The research results are printed in the current edition of the Journal of Experimental Medicine.

"One of the major components of the immune system are T cells, a form of white blood cell. These cells are programmed to look for certain kinds of disease-causing pathogens, then destroy them and the cells infected by them," said Nikolich-Zugich who also serves as a professor of molecular microbiology and immunology in the OHSU School of Medicine, and is a senior scientist at the OHSU Oregon National Primate Research Center. "Throughout our lives, we have a very diverse population of T cells in our bodies. However, late in life this T cell population becomes less diverse, potentially resulting in a higher level of susceptibility to disease. We think we have found one of the key reasons behind this age-related susceptibility."

Specifically, in old age, the number of CD8 T cells diminishes. CD8 T cells have two functions: to recognize and destroy abnormal or infected cells, and to suppress the activity of other white blood cells to protect normal tissue. The scientists believe that late in life a different kind of CD8 T cell is increasingly produced by the body. These cells, called T cell clonal expansions (TCE), are less effective in fighting disease They also have the ability to accumulate quickly as they have a prolonged lifespan and can avoid normal elimination in the organism.

In the end, these TCE cells can grow to become more than 80 percent of the total CD8 population. The accumulatio
'"/>

Contact: Jim Newman
newmanj@ohsu.edu
503-494-8231
Oregon Health & Science University
2-Dec-2004


Page: 1 2

Related medicine news :

1. Indiana University researchers closer to helping hearing-impaired using stem cells
2. Protein that helps skin cancer spread identified by Stanford researchers
3. US life expectancy about to decline, researchers say
4. Gene for age-related macular degeneration discovered by Yale researchers
5. Dartmouth researchers find where musical memories are stored in the brain
6. Columbia researchers receive $3 million to combat genetic killer of infants & toddlers
7. US cancer researchers launch first American-Israeli cancer conference
8. USC dental researchers develop first test for predicting cavities in children
9. Young blood revives aging muscles, Stanford researchers find
10. Uric acid may help reduce effects of spinal cord injury, Jefferson researchers find
11. Age should not be a factor in determining heart transplantation eligibility, researchers say

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/19/2019)... ... , ... iPatientCare, a pioneer in cloud-based EHR , ... User Conference (VUCON), which will highlight the impact of patient advocacy on revenue ... VUCON sessions are designed to demonstrate the new products and software ...
(Date:11/16/2019)... (PRWEB) , ... November 15, 2019 , ... ... before in the United States, access to cannabis via well-managed dispensaries becomes more ... industry. Wise Business Plans, industry-leading online provider of state-of-the-art, online, custom cannabis business ...
(Date:11/15/2019)... Tenn. (PRWEB) , ... November 15, 2019 , ... ... be hosting a complimentary webinar on comprehensive school physical activity programs (CSPAP) on ... architects, architects, planners, and recreation and park professionals, this one-hour and 15-minute webinar ...
(Date:11/14/2019)... , ... November 14, 2019 , ... ... Maryland Health Care System reminds community members, businesses and organizations about the benefits ... a global movement that inspires hundreds of millions of people to give, collaborate ...
(Date:11/14/2019)... ... ... BioInformatics Inc., part of Science and Medicine Group, the leading research and advisory ... nominated for a Life Science Industry Award for launching one of the ... have recognized manufacturers of the “tools of science” that help advance biological research and ...
Breaking Medicine News(10 mins):
(Date:11/19/2019)... ... , ... HashCash Consultants is going to aid a major Pharma company with ... for precision drugs. , The collaboration is expected to streamline the process of sharing ... control over their genome records and the way it is used. They are also ...
(Date:11/16/2019)... COLUMBUS, Ohio (PRWEB) , ... November 15, 2019 ... ... and older adults living with memory impairment, has announced the Best Memory Care ... location, access to experts, facility features and amenities. , According to the ...
(Date:11/15/2019)... , ... November 15, 2019 , ... Mold doesn’t need ... that include moisture that isn’t necessarily detectable to the eye or by touch. ... mold when nothing is wet” by explaining the conditions that mold needs to grow ...
Breaking Medicine Technology:
Cached News: