Medical Center and the Howard Hughes Medical Institute at the University of California at San Francisco have discovered
the molecular mechanism by which tamoxifen blocks the effects of estrogen, a
process that has been shown to prevent breast cancer in some women at high risk.
The results, published in the December 23 issue of Cell, provide valuable clues about ways to design new, more
effective disease-preventing medications with fewer side effects.
| ||"The goal is to figure out how to make drugs that
retain the benefits of estrogen for brain, bone and heart and also have the
benefits of estrogen blockers for the breast and uterus," said Geoffrey Greene, Ph.D.,
professor in the Ben May
Institute of Cancer Research at the University of Chicago and a senior author of
the study. "Now we have precise three-dimensional shapes of the complex that
forms between several of these molecules and the estrogen receptor."
"These structural studies clarify how estrogens turn on genes and show
precisely how tamoxifen blocks this process," said first-author Andrew Shiau, a
graduate student in biochemistry & biophysics at UC San Francisco. "This
sets the stage for intentional design of drugs with precise and selective
Estrogen has many health benefits. It delays the buildup of artery-clogging
plaque, prevents bone loss leading to osteoporosis, and may even postpone the
onset of Alzheimer's disease. These benefits disappear at menopause, when women
stop making significant amounts of estrogen. Although taking replacement
estrogen can restore these benefits, and prevent the hot flashes of menopause,
continued exposure to this hormone increases a woman's risk of breast or uterine
Designer estrogens, also known as selective estrogen receptor modulators
(SERMs), are a class of drugs that fPage: 1 2 3
Contact: John Easton
University of Chicago Medical Center
Related medicine news :
1. Views from space help oil prospectors see deep underground
2. Imaging Camera Developed At Toshiba Stroke Research Center Could Provide Views Of Tiniest Brain Vessels
3. Managed Care Symposium Sponsored By Society Of Actuaries Examines HEDIS, Stakeholders Views
4. Tamoxifens risks similar in African American and white women
5. Tamoxifen for prevention of breast cancer encouraging results but risks still unclear
6. Tamoxifen and estrogen have similar effects on the brain
7. Tamoxifen found to increase risk of endometrial cancer
8. Synthetic progestin damages, estrogen protects blood vessels in animal model
9. Synthetic marijuana reduces agitation in patients with Alzheimers
10. Synthetic marijuana compound reduces agitation, improves appetite in Alzheimers patients
11. Synthetic rubber kills germs on contact
(Date:5/25/2013)... According to an article in the June 2013 issue ... million Americans tan indoors each year and an unknown number ... health risks. New research suggests that UV rays may ... brains of some tanners (Go to goo.gl/hdwnz). , “There ... say that I fully support this contention from a scientific ...
(Date:5/25/2013)... Dr. Leslie Gerstman announced today ... lift skin on the neck, on the brow and under ... Aesthetics. , Ultherapy is a non-surgical procedure for the face ... to lift the skin over time. The use of FDA-cleared ... and then treat the deepest support layers of the skin ...
(Date:5/25/2013)... A disorder of the nerves, Diabetic neuropathy ... to neuropathy expert doctor Helen C Lin, on Medscape ... disorder affects almost 50% of all Diabetic patients, making ... high blood sugar levels in the body are the ... usually tend to have abnormally high blood sugar levels. ...
(Date:5/25/2013)... The report “Global Food Encapsulation Market ... Ingredients, Shell Materials, Packaging, & Geography: Trends & ... market with analysis and forecasting of the global ... driving and restraining factors for the global food ... challenges. The market is segmented and revenue are ...
(Date:5/25/2013)... May 25, 2013 Absolute Surgical Specialists, serving ... of the NALA’s businesses throughout the country participating in Shop ... participate in the nationwide event as he understands what military ... in the Army. He said, “I wanted to give something ... serve, but I live here too.” , Shop Local for ... Breaking Medicine News(10 mins):Health News:Sun Damage – Are UV Rays Addictive? 2Health News:Dr. Leslie Gerstman Is Now Offering the Non-surgical Facelifting Procedure – Ultherapy – in NYC and NJ 2Health News:Diabetic Neuropathy treatment hits new grounds- Neuracel launches the complete natural treatment 2Health News:Food Encapsulation Market to Reach $42 Billion by 2016 - New Report by MarketsandMarkets 2Health News:Food Encapsulation Market to Reach $42 Billion by 2016 - New Report by MarketsandMarkets 3Health News:Dr. Craig Amshel of Absolute Surgical Specialists Offering Bowel Prep During the Shop Local for a Cause Event 2
(Date:5/23/2013)... , May 23, 2013 Nephros, Inc. (OTC ... medical device company that develops and sells high performance ... its rights offering. In addition, the concurrent temporary reduction ... expired on May 17, 2013. Nephros estimates ... from the rights offering. A portion of the proceeds ...
(Date:5/23/2013)... -- Hadasit Bio-Holdings Ltd. (TASE: HDST, OTC: HADSY), a ... intellectual property developed and owned by Hadassah University ... research center, today announced that its portfolio company, ... the Israeli Ministry of Industry and Commerce, Office ... development and advance clinical trials. Cell Cure,s development ...
(Date:5/23/2013)... , May 23, 2013 Texas, premier physician ... deliver doctors the survival tools they need to provide ... in today,s health care marketplace. "I am ... save local practices," said Stephen L. Brotherton ... (TMA). " Texas doctors are determined ... Breaking Medicine Technology:Nephros Announces Completion of Rights Offering 2Nephros Announces Completion of Rights Offering 3Nephros Announces Completion of Rights Offering 4Hadasit Bio-Holdings Ltd. Portfolio Company - Cell Cure Neurosciences Ltd. Received Additional Government Support 2TMA Launches Physician Services Organization for Patient Care 2TMA Launches Physician Services Organization for Patient Care 3TMA Launches Physician Services Organization for Patient Care 4