HOME >> MEDICINE >> NEWS
Viral DNA sequence a possible trigger for breast cancer

A small sequence of DNA in the envelope (Env) protein of a mouse breast tumor virus (called MMTV) can transform breast cells into cancer cells, according to a study by Katz et al. in the February 7 issue of The Journal of Experimental Medicine. The ability of this motif to transform cells single-handedly suggests that viral infection may be an important and previously unrecognized trigger for breast cancer.

The DNA sequence in question is usually found in immune cells and helps trigger the activation and proliferation of the cells. These sequences have also been found in proteins from some other cancer-causing viruses such as Epstein Barr virus and Kaposi's sarcoma virus, but what role this sequence plays in cancer development has remained unexplored.

Katz and colleagues now show that this sequence is contained in the Env protein of MMTV and show that expression of Env in mouse breast cells transforms them. This study puts the spotlight on a potential new mechanism for virus-induced breast cell transformation, which has largely been attributed to the integration of viral DNA into locations that trigger the expression of host cancer-causing genes. An intriguing wrinkle to this study is the previously reported presence of sequences highly homologous to MMTV Env protein in the DNA of as many as 40% of human breast tumors, although a human homologue of MMTV has yet to be found.


'"/>

Contact: Nickey Henry
henryn@rockefeller.edu
212-327-8575
Journal of Experimental Medicine
31-Jan-2005


Page: 1

Related medicine news :

1. New Clinical Data Indicates LEUKINE Maintains Viral Suppression And Extends Duration Of Antiretroviral Therapy Utility In People With AIDS
2. Teen athletes continue tobacco use, despite severe consequences
3. Study examines consequences of Thailands war on drugs
4. Consequences of SARS revealed
5. Studies examine risk factors and potential consequences associated with prehypertension
6. Survey of adults reveals life-long consequences of ADHD
7. Genome sequence reveals leaner, meaner intestinal parasite
8. Neurons that play truth or consequences
9. False memories, failing recall are not an inevitable consequence of aging, research suggests
10. 33-year study emphasizes lethal consequences of heroin addiction
11. Researchers complete sequence and gene map of human major histocompatibility complex

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Viral DNA sequence possible trigger for breast cancer

(Date:9/1/2015)... ... ... Agriculture innovation, urban farming, local food access, and sourcing from sustainable and ... 4th Annual Sustainable Agriculture Conference : “Innovation and the Rise of Local Food,” ... keynotes Pierre Sleiman, founder and CEO of Go Green Agriculture, and Daron “Farmer D” ...
(Date:9/1/2015)... ... September 01, 2015 , ... METTLER TOLEDO ... available. With the Connectivity Kit, EasySampler data is automatically transferred to, and ... experiment, on a touchscreen platform. , EasySampler fully automates the sampling process ...
(Date:9/1/2015)... (PRWEB) , ... September 01, 2015 , ... ... date, more than 1,500 investor-families have received permanent green cards (I-829 petition approval) ... , The I-829 petition is the final step of the EB-5 visa process ...
(Date:9/1/2015)... Beach, FL (PRWEB) , ... September 01, 2015 ... ... pharmacy discount cards, launched its consumer-friendly, informational video this week to coincide with ... http://www.USAMedicalCard.com/video . , According to the CDC, elementary school children are ...
(Date:9/1/2015)... ... September 01, 2015 , ... AdvantagePlusCaregivers.com® ... to access caregivers and what to look for and expect when searching for ... Founded in 2006 in Canoga Park, CA by CEO, Richard Weatherman and Co-Founder ...
Breaking Medicine News(10 mins):Health News:Experts in Urban and Local Food Systems Development to Address Seedstock Sustainable Agriculture Conference Nov. 3-4 Discounted ticket sales end Sept. 4 2Health News:Experts in Urban and Local Food Systems Development to Address Seedstock Sustainable Agriculture Conference Nov. 3-4 Discounted ticket sales end Sept. 4 3Health News:Experts in Urban and Local Food Systems Development to Address Seedstock Sustainable Agriculture Conference Nov. 3-4 Discounted ticket sales end Sept. 4 4Health News:Experts in Urban and Local Food Systems Development to Address Seedstock Sustainable Agriculture Conference Nov. 3-4 Discounted ticket sales end Sept. 4 5Health News:New Technology Allows Unattended Sampling and Synthesis of Chemical Reactions 2Health News:New Technology Allows Unattended Sampling and Synthesis of Chemical Reactions 3Health News:CanAm Enterprises Reaches Another Milestone with More Than 1,500 I-829 Petition Approvals 2Health News:USA Medical Card Launches New FAQ Video During Back-to-School 2Health News:AdvantagePlusCaregivers.com® Launches New Website for Corporate and Franchisee Locations in 3 States 2
(Date:9/1/2015)... 1, 2015 Within just two years after ... has rapidly reached 3,000 employees worldwide. This increase ... the injectable drug delivery market and SHL,s effective ... leader in the design and manufacturing of auto ... robust manufacturing capabilities, a lean supply chain, strong ...
(Date:9/1/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/r8v22b/regulatory ) ... for Support Staff (London, UK - September 24-25, 2015)" ... two day course provides an introduction to Pharmaceutical Regulatory ... been designed specifically for those working in a support ... overview of EU regulatory procedures required to register products ...
(Date:9/1/2015)... 1, 2015 Pressure BioSciences, Inc. (OTCQB: ... the development and sale of broadly enabling, pressure ... worldwide life sciences industry, today announced the publication ... Company,s PCT Platform could play a significant role ... role is based on PCT,s unique ability to ...
Breaking Medicine Technology:SHL Group Reaches Major Milestone of 3000 Employees 2Regulatory Affairs for Support Staff Seminar (London, UK - September 24-25, 2015) 2New Scientific Publication Suggests Pressure BioSciences' PCT Platform Could Play Significant Role in Personalized/Precision Medicine 2New Scientific Publication Suggests Pressure BioSciences' PCT Platform Could Play Significant Role in Personalized/Precision Medicine 3New Scientific Publication Suggests Pressure BioSciences' PCT Platform Could Play Significant Role in Personalized/Precision Medicine 4New Scientific Publication Suggests Pressure BioSciences' PCT Platform Could Play Significant Role in Personalized/Precision Medicine 5
Cached News: