HOME >> MEDICINE >> NEWS
Viral DNA sequence a possible trigger for breast cancer

A small sequence of DNA in the envelope (Env) protein of a mouse breast tumor virus (called MMTV) can transform breast cells into cancer cells, according to a study by Katz et al. in the February 7 issue of The Journal of Experimental Medicine. The ability of this motif to transform cells single-handedly suggests that viral infection may be an important and previously unrecognized trigger for breast cancer.

The DNA sequence in question is usually found in immune cells and helps trigger the activation and proliferation of the cells. These sequences have also been found in proteins from some other cancer-causing viruses such as Epstein Barr virus and Kaposi's sarcoma virus, but what role this sequence plays in cancer development has remained unexplored.

Katz and colleagues now show that this sequence is contained in the Env protein of MMTV and show that expression of Env in mouse breast cells transforms them. This study puts the spotlight on a potential new mechanism for virus-induced breast cell transformation, which has largely been attributed to the integration of viral DNA into locations that trigger the expression of host cancer-causing genes. An intriguing wrinkle to this study is the previously reported presence of sequences highly homologous to MMTV Env protein in the DNA of as many as 40% of human breast tumors, although a human homologue of MMTV has yet to be found.


'"/>

Contact: Nickey Henry
henryn@rockefeller.edu
212-327-8575
Journal of Experimental Medicine
31-Jan-2005


Page: 1

Related medicine news :

1. New Clinical Data Indicates LEUKINE Maintains Viral Suppression And Extends Duration Of Antiretroviral Therapy Utility In People With AIDS
2. Teen athletes continue tobacco use, despite severe consequences
3. Study examines consequences of Thailands war on drugs
4. Consequences of SARS revealed
5. Studies examine risk factors and potential consequences associated with prehypertension
6. Survey of adults reveals life-long consequences of ADHD
7. Genome sequence reveals leaner, meaner intestinal parasite
8. Neurons that play truth or consequences
9. False memories, failing recall are not an inevitable consequence of aging, research suggests
10. 33-year study emphasizes lethal consequences of heroin addiction
11. Researchers complete sequence and gene map of human major histocompatibility complex

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/31/2016)... FL (PRWEB) , ... May 31, 2016 , ... ... its innovative herbal energy pouches, on World No Tobacco Day . The ... select retail locations later on this summer. , The new flavor is best ...
(Date:5/31/2016)... ... May 31, 2016 , ... Dr. Charles A. Ditta attained his Doctor of ... the class of 1986, where he graduated in the top ten percentile of his ... Livingston since 1989. He has been a member in good standing for thirty years ...
(Date:5/31/2016)... N.J. (PRWEB) , ... May 31, 2016 , ... ... and print media enterprise focused on patients with cancer, has added Cancer ... readers and website visitors with more timely content on continuing successful careers while ...
(Date:5/30/2016)... ... May 30, 2016 , ... ... inside of FCPX," said Christina Austin - CEO of Pixel Film Studios. ... within Final Cut Pro X. Choose from abstract transitions to more simple wipes ...
(Date:5/30/2016)... ... May 30, 2016 , ... Another ER facility operated ... Plano, located at 3960 Legacy Drive, Plano, TX and is open 24 hours daily. ... Commerce followed by a medical open house. The Jasper High School band entertained attendees ...
Breaking Medicine News(10 mins):
(Date:5/30/2016)... SAN FRANCISCO , May 30, 2016 /PRNewswire/ ...  is expected to reach USD 7.3 billion by ... View Research, Inc. The increasing natality rate, the ... conditions such as cancer and gastro-intestinal tract diseases ... forecast period.      (Logo: http://photos.prnewswire.com/prnh/20150105/723757 ...
(Date:5/30/2016)... - DCGI grants limited approval to market Stempeucel® product for treating ... becomes 5th off-the-shelf Stem cell product to be approved by a ... (also known as Thromboangiitis Obliterans) is a major unmet medical need ... Prevalence of Buerger,s Disease is estimated to be 1,000,000 in ... European Community & USA Stempeutics ...
(Date:5/30/2016)... May 30, 2016 Eye expert ... premature babies to seek an eye examination ...     Moorfields Eye Hospital Dubai, the ... London , has identified premature babies as a special ... of their particular vulnerability to retinopathy of prematurity (ROP). ROP is ...
Breaking Medicine Technology:
Cached News: