Virco establishes comprehensive set of clinical cutoffs for the vircoTYPE HIV-1 resistance test

Washington, D.C., October 31, 2004 Investigators from Virco today presented data that establishes a comprehensive set of clinical cutoffs -- a newly established threshold for optimal selection and evaluation of antiretroviral regimens -- for the virco®TYPE HIV-1 resistance test. These reference values are derived from the largest clinical outcomes database used to generate clinical cutoffs, and apply a consistent and clinically relevant approach to help physicians better evaluate HIV drug resistance information. These clinical cutoffs are available for a wider range of antiretroviral drugs than those offered by other HIV resistance tests.

In her presentation today at the 44th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Lee Bacheler, PhD, vice president, Clinical Virology, at Virco, demonstrated how clinical cutoffs for the virco®TYPE HIV-1 assay, based on a large and high-quality outcomes database that incorporates more than 3,000 therapeutic regimens, provide physicians with clinically relevant resistance information. She and her colleagues employed virco®TYPE analysis of viral genotypes to predict quantitative phenotypic resistance levels. Mathematical models of virologic response to antiretroviral drugs at eight and 24 weeks versus baseline fold change in IC50 (concentrations of drugs that inhibit 50% of viral replication) were constructed using linear regression. Clinical cutoffs (CCOs) were defined as virco®TYPE-predicted fold change values for 20% and 80% loss of viral load response.

"Our study supports the value of clinical cutoffs in facilitating rational selection of antiretroviral treatment," commented Dr. Bacheler. "The clinical cutoffs enhance the value of the virco®TYPE HIV-1 test by applying consistent definitions across antiretroviral drugs. The results are more closely related to actual treatment practices, with the potential to improve medical management of people with HIV." <

Contact: Catherine Collins
Sensei Health

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