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Vitamin supplement use may reduce effects of Alzheimer's disease

d towards reduced Alzheimer's disease with a combination of vitamin E and C supplements, even after controlling for age, sex, education and general health. However, there was no notable reduction in the risk of Alzheimer's disease with vitamin E or vitamin C alone or with multivitamins. Multivitamins typically contain the recommended daily allowance of vitamin E (22 IU or 15 mg) and vitamin C (75-90 mg), while individual supplements contain doses up to 1,000 IU of vitamin E and 500-1,000 mg or more of vitamin C.

The researchers explained that the use of vitamins E and C may offer protection against Alzheimer's disease when taken together in the higher doses available in individual supplements. In addition, there may be some protective effect with vitamin E when it is combined with the lower doses of vitamin C found in multivitamins.

Dr. Zandi said, "Further study with randomized prevention trials is needed before drawing firm conclusions about the protective effects of these antioxidants. Such trials should consider testing a regimen of vitamin E and C in combination. If effective, the use of these antioxidant vitamins may offer an attractive strategy for the prevention of Alzheimer's disease."


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Contact: Kenna Brigham
paffairs@jhsph.edu
410-955-6878
Johns Hopkins University Bloomberg School of Public Health
19-Jan-2004


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