Welcome alternative to warfarin for people at high risk of stroke

Results of an international study in this week's issue of THE LANCET provide strong evidence that the oral direct thrombin-inhibitor ximelagatran could be a safe and effective alternative to warfarin in reducing stroke among people with atrial fibrillation.

Atrial fibrillation (irregular and rapidly beating atria) increases the risk of cardiac blood clots, which can cause ischaemic stroke. Warfarin has been used for decades for people at high risk of stroke because of its blood-thinning capability; however there are many drawbacks of warfarin treatment: an increased risk of bleeding, and possible interaction with food and other medication necessitating at least monthly blood testing and frequent dose adjustment. The oral direct thrombin-inhibitor ximelagatran could be a more reliable alternative to warfarin for people at high stroke risk.

In an international study (SPORTIF III: Stroke Prevention using an ORal Thrombin Inhibitor in atrial Fibrillation), 3407 patients from Europe, Asia, and Australia with atrial fibrillation and one or more stroke risk factors were randomly allocated warfarin or oral ximelagatran. Average follow-up took place after 17 months.

Oral ximelagatran was at least as effective in reducing the frequency of stroke or systemic blood clots (the primary outcomes) as warfarin (relative risk reduction 30%, absolute risk reduction 0.7% for ximelagatran; however this was not statistically significant). Rates of disabling or fatal stroke, death, and major bleeding were similar between both groups.

Lead investigator S Bertil Olsson from University Hospital Lund, Sweden, comments: "We have shown that ximelagatran, administered in a fixed dose without coagulation monitoring, protects high-risk patients with atrial fibrillation against thromboembolism at least as effectively as well-controlled warfarin, and is associated with less bleeding. The preliminary reported SPORTIF V trial presented at the November 2003 American H

Contact: Joe Santangelo

Page: 1 2

Related medicine news :

1. Costs of antidepressants could have funded effective alternatives
2. Third of European cancer patients use complementary and alternative therapies
3. Complementary & alternative medicine use
4. Complementary and alternative therapies and conventional medical therapies
5. Cruise ships -- An alternative to assisted living facilities for the elderly?
6. Honey could be healthy alternative to high-fructose corn syrup in Halloween candy
7. MRI scans could be acceptable alternative to x-rays
8. More than one-third of US adults use complementary and alternative medicine
9. Survey provides comprehensive look at use of complementary and alternative medicine in US
10. Electromagnetic breast imaging tested as alternative to mammography
11. Seal of approval scheme needed for complementary and alternative websites

Post Your Comments:

(Date:9/3/2020)... , ... September 03, 2020 , ... ... Show 2021 will be held Wednesday, April 7, to Saturday, April 10, 2021, ... , Medical Spa Show is a national trade show for non-invasive medical aesthetic ...
(Date:9/1/2020)... ... September 01, 2020 , ... ... $3 million convertible note financing, which will be used to accelerate the commercialization ... from this financing, the company will continue to expand its customer base of ...
(Date:8/31/2020)... YORK (PRWEB) , ... August 31, 2020 , ... ... nation’s largest non-profit organization devoted exclusively to funding innovative lymphoma research and serving ... patient services – today announced the 10th Anniversary of Blood Cancer Awareness Month ...
(Date:8/31/2020)... ... August 31, 2020 , ... Colorado State University Global (CSU ... affordable online education – is proud to announce its new master’s degree in ... its kind in the nation, the 60-credit hour program is designed to provide ...
(Date:8/31/2020)... ... August 31, 2020 , ... Dr. Chang has over 20 ... and other developmental disabilities, as well as supporting staff in caring for patients ... school consultation, and staff development. She joined the company in 2015 as Chief ...
Breaking Medicine News(10 mins):
(Date:8/31/2020)... ... August 31, 2020 , ... Continuing ... - a broad-spectrum sanitization, disinfection and deodorization provider - is proud to announce ... and disinfecting services for businesses and residents throughout the area. , Germinator provides ...
(Date:8/27/2020)... ... August 27, 2020 , ... ... today announced the successful completion of their 2020 System and Organizational Controls (SOC) ... HITRUST® interim assessment and MARS-E compliance assessment. These achievements reflect their long-standing commitment ...
(Date:8/27/2020)... ... August 27, 2020 , ... Bridge To A Cure Foundation announces the appointment ... and pediatric neuro-oncologist who serves on the Board of Directors at The Preston Robert ... Medical School. , Internationally recognized, Dr. Friedman is a widely published author of more ...
Breaking Medicine Technology:
Cached News: