HOME >> MEDICINE >> NEWS
When 'switched on' muscle stem cells morph to resemble nerve cells

HOUSTON -- Taking a major step forward in stem cell biology, researchers at The University of Texas M. D. Anderson Cancer Center have turned muscle progenitor cells -- stem cells that are "committed" to becoming muscle tissue -- into cells that look and act like neurons (nerve cells).

Using an artificial gene they created, the researchers "switched on" a panel of genes that are normally silent in the muscle cells, causing them to morph into cells that show biochemical, physiological, and structural properties of neurons.

The researchers say the advance, published in the April 15 issue of Genes and Development, provides evidence that stem cells could be profoundly "flexible" -- able to develop into different cell types.

"It is amazing to know that the fate of a cell can be changed by a single molecule," says the lead author Sadhan Majumder, Ph.D., an associate professor in the Department of Cancer Genetics. "If we can redirect muscle progenitor cells to become cells that have the properties of neurons, it may be possible to use the same kind of technique to potentially change the fate of other stem cell types."

The work was conducted in laboratory cell cultures of "myoblasts," the progenitor muscle stem cells, and the new cells were then injected into the brains of healthy mice, where the cells did not cause any ill effects. Majumder says the next phase of the research is the "big test, whether these new cells can replace neurons that are damaged inside the body. That would be a remarkable step towards neuroregeneration."

To date, nerve cell regeneration from nonneural stem cells primarily has been studied using bone marrow cells, but mouse experiments that suggested these stem cells could convert to nerve cells have been controversial. Some investigators suspect that manipulated bone marrow cells are either contaminated with neural stem cells or get fused with neuronal stem cells present in the brain, and so only appeared t
'"/>

Contact: Heather Russell
hrrussel@mdanderson.org
713-792-0655
University of Texas M. D. Anderson Cancer Center
14-Apr-2004


Page: 1 2 3

Related medicine news :

1. Hopkins begins human trials with donor adult stem cells to repair muscle damaged from heart attack
2. Speakers cramp, a new type of involuntary mouth-, lip-muscle movement
3. Young blood revives aging muscles, Stanford researchers find
4. Stem cells of limited use for cardiac muscle repair
5. More muscle means better regulation of blood pressure, study finds
6. Risk of muscle-damaging disorder low for most commonly prescribed statin drugs
7. Skeletal muscle cells could be source of stem cells for regenerating nerve tissue
8. New insights into muscle adaptation to exercise
9. Using smart fluids to retrain muscles
10. Ads with supersized actors leave men depressed, unhappy with their muscles, UCF study shows
11. Testosterone replacement improves muscle strength, function in HIV-infected women

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/31/2020)... ... August 31, 2020 , ... A Cure for Covid-19 “PTS” with Mediation & Hypnosis ... are in a state of panic, experiencing deep anxiety, immense stress, and right now are ... is timely when most people on the planet are experiencing a great degree of emotional ...
(Date:8/31/2020)... ... August 31, 2020 , ... Dr. Chang has over 20 ... and other developmental disabilities, as well as supporting staff in caring for patients ... school consultation, and staff development. She joined the company in 2015 as Chief ...
(Date:8/29/2020)... ... 29, 2020 , ... When professor and author Randy Pausch was diagnosed with ... would. Rather than become melancholic, however, he put together a final lecture in Carnegie ... Pausch took a negative situation and turned it into something that inspired millions of ...
(Date:8/28/2020)... ... August 28, 2020 , ... WHAT , Hespiro™ ... patients with respiratory conditions, including COVID-19, while reducing the need for scarce mechanical ... captures exhaled gas and scrubs it free of carbon dioxide in a completely ...
(Date:8/28/2020)... ... August 28, 2020 , ... ... Group set out to continue helping the specialty-diet community connect with great, ... gluten-free products, get coupons, enter giveaways, chat with brands & watch over 50 ...
Breaking Medicine News(10 mins):
(Date:9/1/2020)... , ... September 01, 2020 , ... September is National ... accounting for more deaths than any other cancer of the female reproductive system. ... with ovarian cancer and about 14,000 women will die from this disease. Throughout ...
(Date:8/31/2020)... ... August 31, 2020 , ... Cloudticity announced today that Network ... Gold winner in the 15th Annual 2020 Network PG’s IT World Awards®. , ... from Network Products Guide honoring achievements of world’s best in organizational performance, product ...
(Date:8/27/2020)... CONSHOHOCKEN, Pa. (PRWEB) , ... August 27, 2020 ... ... and care coordination software, today announced the successful completion of their 2020 System ... as well as their HITRUST® interim assessment and MARS-E compliance assessment. These achievements ...
Breaking Medicine Technology:
Cached News: