Who enrolls in clinical oncology trials?

SALT LAKE CITY, UTAH--A new study sponsored by the National Cancer Institute shows that a patient's race and the kind of institution where a patient seeks cancer treatment both influence the likelihood of that patient enrolling in an oncology clinical trial. The results were presented today by Benjamin Movsas, M.D., vice chairman of radiation oncology at Fox Chase Cancer Center, at the 45th annual meeting of the American Society for Therapeutic Radiology and Oncology (ASTRO) in Salt Lake City, Utah.

"The purpose of this study was to identify factors that significantly influence accrual to clinical research protocols by analyzing Patterns of Care Study surveys of 3,047 randomly selected radiation patients," explained Movsas.

The new study analyzed Patterns of Care Study surveys done between 1992-94 and 1996-99. Of the patients surveyed, 1,080 had breast cancer, 1,149 had prostate cancer and 818 had esophageal cancer. As part of this NCI-funded national survey, institutions that offer radiation therapy were randomly selected for the study. The patients analyzed in this study had non-metastatic disease and received radiation therapy as definitive or adjuvant therapy.

Trained research associated reviewed 3,047 patient records. The study examined age, gender, race, type of insurance and practice type of treating institution (academic or not) as well as participation in clinical trials.

Overall, only 2.7 percent of all patients were accrued to clinical protocols, which is consistent with national estimates.

"After accounting for the patients' age, gender, race, type of insurance and the type of treating institution via a multivariate analysis, we can see that the practice type and a patient's race were highly significant predictors of whether or not a patient joined a clinical trial," Movsas explained.

More specifically, 9.4 percent of patients treated with radiation therapy at an academic practice enrolled in trials versus 1.7 percent

Contact: Karen Carter Mallet
Fox Chase Cancer Center

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