Whole blood may do more harm than good in pediatric heart surgeries

WINSTON-SALEM, N.C. A standard medical practice at some of the nation's largest children's hospitals using whole, recently donated blood for certain infant open heart surgeries may do more harm than good. Researchers from Wake Forest University Baptist Medical Center and the University of Texas, Southwestern Medical School reported the findings in this week's New England Journal of Medicine.

"A long-time accepted practice has now been tested, and our results show it could actually be worse for infants," said Steven Mou, M.D., principal investigator and assistant professor of anesthesiology at Wake Forest Baptist. "Abandoning this practice could help reduce hospital stays for infants who have surgery for heart defects and help reduce some of the inventory problems that blood banks grapple with."

The study involved 200 children under age 1 who required heart surgery using the heart-lung bypass machine, which adds oxygen to blood and maintains circulation while the heart is stopped for surgery. The research team compared two different blood products used to fill, or "prime" the equipment: whole blood donated within the previous 48 hours and "reconstituted" blood formed by combining red blood cells and plasma. Plasma can be stored up to a year and red cells for 42 days after donation.

The results showed that patients who got the whole blood did no better in terms of bleeding, transfusion requirements, after-surgery complications and mortality than patients who got the reconstituted blood. In fact, infants who received the reconstituted blood had a shorter stay in the intensive care unit (70 hours versus 97 hours) and spent less time on respirator (36 hours versus 53 hours) which could also dramatically affect health care costs.

The researchers believe the differences were because the patients receiving reconstituted blood were observed to accumulate less fluid. Fluid accumulation is a marker for inflammation.

The research wa

Contact: Karen Richardson
Wake Forest University Baptist Medical Center

Page: 1 2 3

Related medicine news :

1. Whole-body CT screening costs overshadow benefits
2. Whole-body CT screening for GI disease may not be effective
3. Whole-body PET/CT scan appears useful for determining tumor stage
4. Whole tomato powder effective in preventing prostate cancer
5. Whole-breast irradiation after lumpectomy may protect women from recurrence long term
6. Whole body PET proves accurate in detecting breast cancer spread
7. Whole grains reduce long-term risk of type 2 diabetes in men
8. Whole-organ pancreas transplants and partial liver transplant programs arepriorities for renowned transplant surgeon at Cedars-Sinai
9. The Whole Truth From Five-Year-Olds
10. A marker for new blood vessel formation in tumors
11. Acupuncture found to lower elevations in blood pressure

Post Your Comments:

(Date:7/19/2019)... ... July 19, 2019 , ... Juvly Aesthetics has announced ... its Director of Marketing and Sales. In his role, Okuley will be leading ... growth while furthering the company’s mission of empowering clients to look and feel ...
(Date:7/18/2019)... ... July 18, 2019 , ... The Radiology Business Management Association ... bills to protect patients from unexpected out-of-network medical bills incurred while receiving care ... Act ( H.R. 3502 ), introduced in the U.S. House by Representatives Raul ...
(Date:7/18/2019)... ... July 18, 2019 , ... NeoTract, a ... the field of urology, today announced that Garrett Matsunaga, MD, Skyline Urology in ... recognizes that Dr. Matsunaga has achieved a high level of training and experience ...
(Date:7/18/2019)... (PRWEB) , ... July 18, 2019 , ... ... Dr. Mark Deutsch is featured in Atlanta, Magazine’s list of “Top Doctors” issue. ... of cosmetic and reconstructive surgery, experience. With specialized training from MD Anderson Cancer ...
(Date:7/18/2019)... ... July 18, 2019 , ... ... being nominated 2019 Texas Monthly Super Doctor Rising Star ! Each ... who they would trust for their own medical care. The Super Doctors research ...
Breaking Medicine News(10 mins):
(Date:7/18/2019)... ... July 18, 2019 , ... NeoTract, a wholly owned ... of urology, today announced that Timothy Lesser, MD, Skyline Urology in Torrance, CA ... Dr. Lesser has achieved a high level of training and experience with the ...
(Date:7/17/2019)... ... July 17, 2019 , ... Soliant, a leading healthcare staffing ... Family Clinic Avera as its 2019 Most Beautiful Hospital in the U.S. In Soliant’s ... million - were cast for the 96 hospitals nominated. Supporters from across the country ...
(Date:7/17/2019)... (PRWEB) , ... July 17, 2019 , ... ... up with the MDA for their fourth annual national “Be Their Muscle” philanthropic ... to transform the lives of kids and adults with muscular dystrophy, ALS and ...
Breaking Medicine Technology:
Cached News: