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Whole tomato powder effective in preventing prostate cancer

tate cancer than rats with unlimited access to food, after controlling for diet type. There appeared to be no interaction between type of diet and the amount of dietary intake, suggesting that tomato products and diet restriction may have independent benefits.

"Our observations support the concept that tomato products contain components in addition to lycopene that may inhibit prostate carcinogenesis," the authors write. They say that more work is needed to understand the role of the various compounds in tomatoes and to determine whether there are additive or synergistic effects between the compounds.

"Many men are consuming lycopene-containing supplements with the hope that they may prevent prostate cancer or enhance the treatment of their prostate cancer," the authors write. "We suggest that a focus on interventions with whole tomato products and energy balance should be a priority while clinical studies simultaneously investigate the risks and benefits of lycopene supplementation."

In an accompanying editorial, Peter H. Gann, M.D., Sc.D., of the Robert H. Lurie Comprehensive Cancer Center at Northwestern University in Chicago, and Frederick Khachik, Ph.D., of the University of Maryland, College Park, note that the study adds to the debate about whether cancer prevention is best achieved with whole foods or with single compounds. They point out that carotenoids and other secondary plant compounds evolved as sets of interacting compounds, and say that this complexity limits the usefulness of reductionist approaches that seek to identify single protective compounds.


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Contact: Linda Wang
jncimedia@oupjournals.org
301-841-1287
Journal of the National Cancer Institute
4-Nov-2003


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